Effect of macular pigment carotenoids on cognitive functions: A systematic review

García-Romera, Marta-C; Silva‐Viguera, María‐Carmen; López-Izquierdo, Inmaculada; López-Muñoz, Alfredo; Capote-Puente, Raúl; Gargallo-Martínez, Beatriz

doi:10.1016/j.physbeh.2022.113891

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Additionally, Feeney et al discovered evidence linking increased plasma zeaxanthin with better processing speed (164) . Although the results of large population studies and clinical trials have been somewhat mixed, a recent review demonstrated a direct relationship among cognitive functions, macular pigment and the intake of lutein and zeaxanthin (165) .…”

Section: The Role Of Lutein and Zeaxanthin In Cognitive Impairmentmentioning

confidence: 99%

Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment

et al. 2023

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Age-related frailty and cognitive decline are complex multidimensional conditions that significantly impact the ability of older adults to sustain functional capacity and independence. While underlying causes remain poorly understood, nutrition continually emerges as one associated risk element. Many studies have addressed the importance of adequate nutrition in delaying the onset of these conditions, but the specific role of micronutrients is not well established. The consideration of pre-frailty as an outcome variable is also limited in the current literature. In this review, we focus on the potential value of maintaining micronutrient sufficiency to sustaining the health of the ageing population. Using data from the Irish longitudinal study on ageing, we consider several vitamins known to have a high prevalence of low status in older adults and their impact on pre-frailty, frailty and cognitive impairment. They include vitamin B12 and folate, both of which are associated with multiple biological mechanisms involved in long-term health, in particular in cognitive function; vitamin D, which has been associated with increased risk of musculoskeletal disorders, depression and other chronic diseases; and the carotenoids, lutein and zeaxanthin, that may help mitigate the risk of frailty and cognitive decline via their antioxidant and anti-inflammatory properties. We show that low concentrations of folate and carotenoids are implicated in poorer cognitive health and that the co-occurrence of multiple nutrient deficiencies confers greatest risk for frailty and pre-frailty in the Irish longitudinal study on ageing cohort. These health associations contribute to evidence needed to optimise micronutrient status for health in the older adult population.

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Section: The Role Of Lutein and Zeaxanthin In Cognitive Impairmentmentioning

confidence: 99%

Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment

et al. 2023

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“…Lutein and zeaxanthin are important components of macula and retina and their levels in these tissues have positively been associated with visual functions (García-Romera et al, 2022). These effects have been clearly demonstrated in clinical trials.…”

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confidence: 98%

“…Lutein and zeaxanthin absorb blue light, exert antioxidant effects, improve vision and prevent the development of cataracts and age-related macular degeneration (Yahia et al, 2018). Interestingly, the levels of these carotenoids in the macule can be used as markers of their concentrations in the brain and cognitive functions (García-Romera et al, 2022).…”

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confidence: 99%

Dietary sources, bioavailability and health effects of carotenoids

et al. 2022

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Carotenoids are non-polar compounds found in fruits and vegetables. The consumption of these compounds has been associated with many beneficial effects on human health, especially on the prevention of chronic diseases that are currently considered as problems of public health. These effects have mainly been attributed to the antioxidant properties of carotenoids, although many other mechanisms are involved, including the influence of carotenoids in the expression of genes involved in the pathogenesis of these diseases. Unfortunately, the bioavailability of these compounds is very limited. The effects of several factors on carotenoid bioavailability have been studied in order to identify the best strategies to increase the absorption of these compounds and, consequently, their bioactivity. Currently, important efforts have being carried out to determine the content and bioavailability of carotenoids from underutilized foods and the mechanisms involved in their bioavailability and beneficial effects. In this review, the recent findings on carotenoid sources, bioavailability and bioactivity are discussed.

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Hallmarks of aging in age-related macular degeneration and age-related neurological disorders: novel insights into common mechanisms and clinical relevance

Vujosevic,

Limoli,

Kozak

2024

Eye

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Effect of macular pigment carotenoids on cognitive functions: A systematic review

Cited by 5 publications

References 41 publications

Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment

Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment

Dietary sources, bioavailability and health effects of carotenoids

Hallmarks of aging in age-related macular degeneration and age-related neurological disorders: novel insights into common mechanisms and clinical relevance

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