Effect of macrophage colony-stimulating factor on the function of resident peritoneal macrophages.

Kanada, Tomoko; Shikita, Mikio; Tsuneoka, Kazuko; Sakai, Nobuo; Tomita, Toshio; Kanegasaki, Shiro

doi:10.1248/bpb1978.10.215

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…While, t o our knowledge, this is the first study of the respiratory burst following pretreatment with CSF-1 in combination with other agents, our data with CSF-1 alone appears to contradict some previous reports suggesting that CSF-1 can prime macrophages for enhanced respiratory burst activity (Reed et al, 1987;Wing et al, 1985a;Kanada et al, 1987). These reports have found priming effects at low CSF-1 concentrations, although decreased effects (Wing et al, 1985a), and even inhibition (Kanada et al, 1987), were observed at high CSF-1 concentrations (lo3 U/ml and 2 5 x lo3 Uiml, respectively!. In contrast, we have been unable to demonstrate priming of either BMM or RPM by LPS-free CSF-1 using a range of CSF-1 concentrations (data not shown).…”

Section: Discussioncontrasting

confidence: 79%

Colony stimulating factor‐1 Is a negative regulator of the macrophage respiratory burst

Phillips

Hamilton

1990

Journal Cellular Physiology

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Several cytokines have previously been shown to prime macrophages for enhanced release of oxygen radicals in response to subsequent stimulation. We now demonstrate that the presence of the macrophage-specific colony stimulating factor-1 (CSF-1) inhibits the priming of murine macrophages by a variety of agents including tumor necrosis factor alpha, granulocyte/macrophage colony stimulating factor, interferon-gamma, and bacterial lipopolysaccharide. CSF-1 is also able to reduce the respiratory burst in the absence of priming. Our results indicate that CSF-1 is a potent negative regulator of the macrophage respiratory burst which acts to oppose the priming (enhancing) action of macrophage activating agents. We propose that CSF-1 may have a potentially important and previously unrecognized, role as a physiological regulator which restricts or terminates the activation of macrophages in order to prevent an uncontrolled inflammatory reaction.

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Section: Discussioncontrasting

confidence: 79%