Effect of Macleaya cordata and Magnolia officinalis plant extracts on oxidative stress control in lambs fed a high-concentrate diet

Lima, Tiago Ronimar Ferreira; Gallo, Sarita Bonagurio; Rosa, Alessandra Fernandes; Silva, Saulo da Luz e; Brochado, T.; Bezerra, Helena Viel Alves; Putrino, Soraia Marques; Martins, Murilo Battistuzzi; Leme, Paulo Roberto

doi:10.5713/ajas.19.0050

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…This includes antimicrobial and anthelminthic properties [ 33 ]. Moreover, other experiments in sheep have observed that Macleaya cordata extracts reduce oxidative stress [ 34 ], including in heat-stressed animals where improvements in feed conversion efficiency were observed [ 35 ]. Isoquinoline alkaloids are widely reported to have anti-inflammatory properties [ 31 , 36 ], with the effect at least partially mediated via changes in NF- k β [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Shakeri

Suleria

et al. 2020

Antioxidants

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Heat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory responses, particularly within the gastrointestinal tract. This study aimed to investigate whether plant-derived betaine and isoquinoline alkaloids could ameliorate HS in pigs. Fifty female Large White × Landrace grower pigs, which were acclimated to control (CON), control plus betaine (BET), or control plus isoquinoline alkaloids (IQA) diets for 14 days were then exposed to heat stress or thermoneutral condition. Both BET and IQA partially ameliorated increases in respiration rate (p = 0.013) and rectal temperature (p = 0.001) associated with HS conditions. Heat stress increased salivary cortisol concentrations and reduced plasma creatinine, lactate, and thyroid hormone concentrations. Heat stress increased colon FD4 permeability, which was reduced by IQA (p = 0.030). Heat stress increased inflammation in the jejunum and ileum, as indicated by elevated interleukin-1β (p = 0.022) in the jejunum and interleukin-1β (p = 0.004) and interleukin-8 (p = 0.001) in the ileum. No differences in plasma total antioxidant capacity (TAC) were observed with HS, but betaine increased plasma TAC compared to IQA. Dietary BET increased betaine concentrations in the jejunum, ileum (p < 0.001 for both), plasma, liver, kidney (p < 0.010 for all), urine (p = 0.002) and tended to be higher in muscle (p = 0.084). Betaine concentration was not influenced by HS, but it tended to be higher in plasma and accumulated in the liver. These data suggest that betaine and isoquinoline alkaloids supplementation ameliorated consequences of heat stress in grower pigs and protected against HS induced increases in colonic permeability.

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Section: Discussionmentioning

confidence: 99%

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Shakeri

Suleria

et al. 2020

Antioxidants

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“…Despite the changes in DMI, ADG and ADG: DMI remained unaffected by MCE ( p = 0.68). Previous research [ 11 , 17 , 18 , 19 ] also does not show an impact of feeding MCE on the ADG of ruminants. On the other hand, feeding MCE seems to influence individual tissue development and thus the carcass composition of cattle [ 11 ].…”

Section: Resultsmentioning

confidence: 72%

Assessing Performance and Safety of Feeding a Standardized Macleaya cordata Extract to Calves

Matulka¹,

Wickramasinghe

Dohms

et al. 2022

Animals

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This study examined the effects of Sangrovit®, a Macleaya cordata plant extract (MCE) preparation on feed intake, growth, blood chemistry, and tissue-residue levels of calves. Twenty male and 20 female calves (~5 d of age) were assigned to one of four daily Sangrovit® doses: 0.0 and 0.0 (CTL), 2.0 and 4.0 (D1), 5.0 and 10.0 (D2), and 10.0 and 20.0 (D3) g/calf in pre-weaning (5 to 49 d of age) and post-weaning (50 to 95 d of age) periods, respectively. Sangrovit® doses were fed in milk replacer pre-weaning and top-dressed on calf starter post-weaning. Milk replacer and calf starter intake was recorded daily. Body weight, hematology, and serum chemistry were measured at 5, 49, and 95 d of age. Calves were slaughtered at 95 d of age for MCE tissue residue analysis. Compared to CTL, D1 increased milk-replacer intake (4.90 to 5.09 L/day), but decreased calf starter intake pre- (0.65 to 0.53 kg/d) and post-weaning (3.42 to 3.20 kg/d). No Sangrovit® dose affected average daily gain. The hematology and blood chemistry of all treatment groups fell within the ranges of healthy calves. Results showed no adverse effects of MCE on health and growth performance of calves when fed up to 10.0 g/calf/day pre-weaning and up to 20.0 g/calf/day post-weaning.

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“…High‐concentrate diets can interfere with the metabolism of ruminants, resulting in the release of diverse compounds into the blood circulation and affecting the redox homoeostasis of the animal (Lima et al, 2020). Additionally, prolonged feeding of a high‐concentrate diet can lead to ruminal and intestinal microbial metabolism disorders and gastrointestinal epithelial inflammation damage and can further aggravate oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Procyanidins regulate colonic metabolome, inflammatory response and antioxidant capacity in lambs fed a high‐concentrate diet

Zhang

et al. 2022

Animal Physiology Nutrition

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This study explored the mechanism by which grape seed procyanidins (GSPs) alleviate colon inflammatory injury induced by a high-concentrate diet in lambs.Forty-eight 1/2 Dorper (♂) × 1/2 Small thin-tailed (♀) crossed male lambs were randomly assigned into four groups: the control group (CON), fed with a highconcentrate diet (concentrate:forage = 7:3) and three GSPs groups fed a highconcentrate diet + 10 (LGSP), 20 (MGSP) and 40 (HGSP) mg/kg body weight (BW) GSPs per day, respectively. The results showed that the levels of interleukin (IL)−1β and tumour necrosis factor (TNF)-α in plasma of lambs of the MGSP (0.155 and 38.52 pg/ml) and HGSP (0.165 and 39.60 pg/ml) groups were significantly lower than those in the CON (0.248 and 48.74 pg/ml) and LGSP (0.245 and 50.52 pg/ml) group (p < 0.05), and levels of IL-1β in colon tissue in the MGSP (28.49 ng/g) and HGSP (26.67 ng/g) groups were also lower (p < 0.05) than that in CON (40.55 ng/g).Metabonomics analysis of colon tissue showed that differentially expressed metabolites were mainly enriched in the arachidonic acid metabolism, citric acid cycle, glycine, serine and threonine metabolism, and peroxisome proliferatoractivated receptor signalling pathway (p < 0.05). In conclusion, GSPs alleviate the colonic epithelium inflammatory response induced by a high-concentrate diet by increasing energy metabolism, amino acid metabolism, antioxidant metabolism and inhibiting arachidonic acid metabolism.

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Effect of Macleaya cordata and Magnolia officinalis plant extracts on oxidative stress control in lambs fed a high-concentrate diet

Cited by 10 publications

References 23 publications

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Assessing Performance and Safety of Feeding a Standardized Macleaya cordata Extract to Calves

Procyanidins regulate colonic metabolome, inflammatory response and antioxidant capacity in lambs fed a high‐concentrate diet

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