2021
DOI: 10.1007/s12035-021-02483-x
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Effect of m-Trifluoromethyl-diphenyl diselenide on the Pain–Depression Dyad Induced by Reserpine: Insights on Oxidative Stress, Apoptotic, and Glucocorticoid Receptor Modulation

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Cited by 9 publications
(2 citation statements)
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“…However, it is worth highlighting that RIM4 and ASI models show nonreflexive pain responses at 6 weeks, when reflexive responses are no longer presented. Furthermore, although it has been reported transient locomotor alterations in reserpine injected animals 71 , 72 , our reported emotional impairments cannot be attributed to reduced locomotor activity since results on 3 and 6 weeks post-induction showed no significant locomotor disturbances. Altogether these results would also support the importance of non-reflexive pain responses in animal models since these symptoms are clinically relevant in chronic pain in humans 4 .…”
Section: Discussioncontrasting
confidence: 67%
“…However, it is worth highlighting that RIM4 and ASI models show nonreflexive pain responses at 6 weeks, when reflexive responses are no longer presented. Furthermore, although it has been reported transient locomotor alterations in reserpine injected animals 71 , 72 , our reported emotional impairments cannot be attributed to reduced locomotor activity since results on 3 and 6 weeks post-induction showed no significant locomotor disturbances. Altogether these results would also support the importance of non-reflexive pain responses in animal models since these symptoms are clinically relevant in chronic pain in humans 4 .…”
Section: Discussioncontrasting
confidence: 67%
“…Furthermore, organoselenium compounds have been reported as promising therapeutics when tested in some depression models. Previous studies have shown their antioxidant, antinociceptive, antidepressant, and anti-inflammatory effects . For this reason, in recent years, selenium has been incorporated to the structure of several heterocycles, generating new hybrid chemical compounds for drug discovery …”
Section: Introductionmentioning
confidence: 99%