Effect of Lycopene on Pharmacokinetic and Pharmacodynamics of Gliclazide in Diabetic Animal Models

Abstract

Background: Several factors contribute to the increased use of herbal products: namely, easy accessibility, perception of herbs as safe alternate treatment, desire for self-medication, and lesser cost. With expanding utilization of home-grown medications, there have been concerns with respect to the security of these items, specifically the potential communication of these medications with regular medications. Certain natural enhancements can cause conceivably perilous symptoms when taken with physician recommended drugs.Objective: To inspect the pharmacodynamic interaction of allicin and gliclazide in animal models and to understand the safety and adequacy.Methods: Single and multiple dose treatments in normal rats, diabetes triggered rats and rabbits to assess the impact of allicin on the gliclazide movement. Blood tests from the examination of animals were utilized for the estimation insulin and glucose levels by utilizing radioimmunoassay technique and science analyzer (computerized) separately. Homeostasis evaluation utilized for assurance of β-cell work.Results: Gliclazide produces huge lessening in blood glucose levels in diabetic animals. In the combination, gliclazide in mix with allicin demonstrated more noticeable diminishment in blood glucose fixation in animals with diabetes. Conclusion:Coadministration of allicin and gliclazide did enhance the antidiabetic activity compared with individual drugs.

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“…Allicin is obtained from Allium sativum (Amaryllidaceae), commonly known AS garlic, used in Indian foods regularly, and it has antidiabetic properties 5 . Allicin shows inhibitory action on CYP enzymes, especially CYP3A4, CYP2C8, CYP2C9 and reported in previous studies 6 . Knowing the influence of allicin on Pioglitazone is more important; alterations in pharmacokinetic and pharmacodynamic parameters were studied.…”

Risk reduction and prevention of cardiovascular diseases: biological mechanisms of lycopene

“…The liver appears to be an insulin-dependent tissue involved in glucose and lipid homeostasis, which is usually severely affected by diabetes. Lycopene can exert its hypoglycemic activity by increasing the activity of hepatic glucokinase and by stimulating the release of insulin from pancreatic beta cells to result in elevated serum insulin levels [56].…”