Effect of luteinized unruptured follicle cycles on clinical outcomes of frozen thawed embryo transfer in Chinese women

Wang, Lina; Qiao, Jie; Liu, Ping; Lian, Ying

doi:10.1007/s10815-008-9225-2

Cited by 20 publications

(16 citation statements)

References 22 publications

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“…Nardo and other scholars [20][21][22][23][24] examined the expression of integrin ανβ3, α4β1 in the endometrium of the fertile women 6 day and 8 days after ovulation, ανβ3, α4β1 was found to be transiently expressed during the implantation window. Meanwhile, the expression of integrin ανβ3 in pregnant women in the implantation window was much higher than that in their non-pregnant counterparts.…”

Section: Discussionmentioning

confidence: 99%

Impact of luteinized unruptured follicles on endometrial receptivity

Yang

Jiang

et al. 2011

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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This study examined the impact of luteinized unruptured follicle (LUF) on endometrial receptivity. The menstrual cycle of 17 LUF patients (LUF group) and 13 ovulatory women (control group) was monitored by measuring LH level in urine and by ultrasonic examination. An endometrial biopsy at the sixth to tenth day after LH surge was taken in all the patients. The expressions of endometrial ER, PR and integrin ανβ3 were immunohistochemically determined. At the same time, the serum levels of E(2) and P were detected by chemiluminescence. The results exhibited that (1) The mean serum P level in LUF group (7.32±2.56 ng/mL) was significantly lower than that in control group (11.17±3.17 ng/mL) (P<0.01). But there was no significant difference in the mean serum E2 levels between LUF group (179.35±81.60 pg/mL) and the control group (198.58±75.23 pg/mL) (P>0.05); (2) The mean expression intensities of ER, PR in endometrium of LUF group (183.86±2.43, 167.94±3.04) were significantly higher than those in control group (109.35±6.31, 105.98±4.07) (P<0.01); (3) The mean expression intensities of integrin ανβ3 in endomtrium of LUF patients (114.90±11.38) were significantly lower than those in control group (191.34±1.82) (P<0.01); (4) The change profile of integrin ανβ3 expression in the endometrium of LUF patients was in positive relation with serum P level (r=0.77, P<0.01), but bore no significant relationship with serum E(2) level (r=0.01, P>0.05). It was concluded that the depression of serum P levels in LUF patients was closely related to the failure of the down-regulation of ER and PR, and the low expressions of integrin ανβ3 also suggested that the delayed implantation and the impaired endometrial receptivity had impact on embryonic implantation.

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Section: Discussionmentioning

confidence: 99%

Impact of luteinized unruptured follicles on endometrial receptivity

Yang

Jiang

et al. 2011

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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“…It occurs in 10 % of the menstrual cycle in a fertile woman but incidence increases with stimulated cycles. 4 Also, it is on the rise due to availability of better imaging modalities. Recent studies have shown that the endometrium proliferates more slowly in LUF cycles than in ovulatory cycles, and women with LUF cycles have a shortened luteal phase, reduced P level and inadequate luteal function.…”

Section: Discussionmentioning

confidence: 99%

“…LUF is observed in 10% of natural menstrual cycles in fertile women, but in stimulated cycles it is higher. 4 The incidence of LUF has been reported to be 25-43% in infertile women 5 . Concerns do exist regarding impact on success of the embryo transfer in a stimulated cycle with LUF.…”

Section: Introductionmentioning

confidence: 99%

Mimicking reproductive endocrinology to achieve successful pregnancy in frozen embryo replacement cycle in luteinized unruptured follicle (LUF

Jain

Malik

Prakash

2018

Int J Reprod Contracept Obstet Gynecol

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Frozen embryo replacement cycles are commonly performed in all ART centres for various indications. In FER cycles, aim is to achieve the synchronization between the endometrium and the embryo. It can be undertaken in a natural or in an artificially prepared endometrium. Artificial preparation utilizes either the ovulation induction agents or hormones. Luteinized unruptured follicle is commonly encountered nowadays due to better resonance USG machines and frequent monitoring. It is still unclear among the practitioners whether to perform an embryo transfer in LUF. In this case report, authors are highlighting that in case of FER cycles using ovulation induction agent, despite inability to ovulate (LUF), if authors are able to achieve optimum synchronization between endometrium and the embryo using USG and serum hormonal levels, successful outcome could be expected.

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“…Follicular cysts were defined as follicles with or without oocytes that contain a large antral cavity and a thin granulosa layer. LUFs were defined as structures with an oocyte surrounded by luteal and granulosa cells, with neovascularization (Wang et al 2008, Fernandois et al 2012. The number of these different ovarian structures was determined in six ovarian sections from each ovary (n = 6 ovaries/group) and expressed as mean ± s.e.m.…”

Section: Ovarian Morphologymentioning

confidence: 99%

A single dose of allopregnanolone affects rat ovarian morphology and steroidogenesis

Pelegrina¹,

Cáceres²,

Giuliani³

et al. 2017

Reproduction

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Allopregnanolone, a progesterone metabolite, is one of the best characterized neurosteroids. In a dose that mimics serum levels during stress, allopregnanolone inhibits sexual receptivity and ovulation and induces a decrease in luteinizing hormone levels. The aim of this work was to examine the effect of an intracerebroventricular administration of allopregnanolone on ovarian morphophysiology, serum and tissue levels of progesterone and estrogen, and enzymatic activity of 3β-hydroxysteroid dehydrogenase, 20α-hydroxysteroid dehydrogenase and 3α-hydroxysteroid oxido-reductase in the ovary and in the medial basal hypothalamus on the morning of estrus. Ovarian morphology was analyzed under light microscopy. The hormone assays were performed by radioimmunoassay. The enzymatic activities were measured by spectrophotometric analysis. The morphometric analysis revealed that, in allopregnanolone-treated animals, the number of secondary and Graafian follicles was decreased while that of atretic follicles and cysts was significantly increased. Some cysts showed luteinized unruptured follicles. There were no differences in the number of tertiary follicles or corpora lutea in comparison with the corresponding control groups. In allopregnanolone-treated animals, progesterone serum levels were increased, while ovarian progesterone levels were decreased. Moreover, 3β-HSD and 3α-HSOR enzymatic activities were increased in the medial basal hypothalamus while ovarian levels were decreased. The enzyme 20α-hydroxysteroid dehydrogenase showed the opposite profile. The results of this study showed that allopregnanolone interferes on ovarian steroidogenesis and ovarian morphophysiology in rats, providing a clear evidence for the role of this neurosteroid in the control of reproductive function under stress situations.

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Effect of luteinized unruptured follicle cycles on clinical outcomes of frozen thawed embryo transfer in Chinese women

Abstract: LUF does not affect the clinical outcomes of FET. Patients of LUF should be included in FET treatment.

Cited by 20 publications

References 22 publications

Impact of luteinized unruptured follicles on endometrial receptivity

Impact of luteinized unruptured follicles on endometrial receptivity

Mimicking reproductive endocrinology to achieve successful pregnancy in frozen embryo replacement cycle in luteinized unruptured follicle (LUF

A single dose of allopregnanolone affects rat ovarian morphology and steroidogenesis

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