Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial

Abstract

Objective: The aim of the study is to determine the effect of lutein combined with vitamin and mineral supplementation on contrast sensitivity in people with age-related macular disease (ARMD). Design: A prospective, 9-month, double-masked randomized controlled trial. Setting: Aston University, Birmingham, UK and a UK optometric clinical practice. Subjects: Age-related maculopathy (ARM) and atrophic age-related macular degeneration (AMD) participants were randomized (using a random number generator) to either placebo (n ¼ 10) or active (n ¼ 15) groups. Three of the placebo group and two of the active group dropped out. Interventions: The active group supplemented daily with 6 mg lutein combined with vitamins and minerals. The outcome measure was contrast sensitivity (CS) measured using the Pelli-Robson chart, for which the study had 80% power at the 5% significance level to detect a change of 0.3 log units. Results: The CS score increased by 0.0770.07 and decreased by 0.0270.18 log units for the placebo and active groups, respectively. The difference between these values is not statistically significant (z ¼ À0.903, P ¼ 0.376). Conclusion:The results suggest that 6 mg of lutein supplementation in combination with other antioxidants is not beneficial for this group. Further work is required to establish optimum dosage levels.

Supplementation With Three Different Macular Carotenoid Formulations in Patients With Early Age-Related Macular Degeneration

“…Of note, concentrations of L are higher in the peripheral macula, compared with the foveola. 56 Previous studies have investigated the impact of macular carotenoid supplementation on CS in subjects with AMD, with most of the studies reporting improvements in the CS after supplementation (with L and Z), 36,37,[57][58][59] although no study to date has tested 60 has shown significant increases in CS at low spatial frequencies after supplementation with either 10 mg L, 20 mg L, or 10 mg L and 10 mg Z (combined), in subjects with early AMD, over a 48-week study period. These findings are in agreement with those reported in this study, which found demonstrable improvements in CS at high spatial frequencies, but only among subjects who were supplemented with a formulation containing MZ, and not among subjects supplementing with high doses of L alone.…”

Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials – Report 1

“…iovs.arvojournals.org j ISSN: However, studies performed to date to test the above hypotheses have been limited in terms of their design (e.g., single-blind), 20 methodology (e.g., measurement devices not optimal or validated), 21,22 outcome measures (e.g., assessing visual function using, for instance, best corrected visual acuity [BCVA] only), 21 and interventions used (e.g., trials using supplements containing either low amounts of carotenoids [thereby limiting bioavailability] 23 and, in most cases, the supplement formulations used only one or two of the three macular carotenoids [typically L and/or Z], 24,25 thereby precluding comment on the impact of supplementation with all three macular carotenoids, a desirable endeavor given that L, Z, and MZ are found in equal amounts at the macula 26 ). In July 2011, the European Research Council (ERC) awarded funding of E1,493,342 to support and conduct the Central Retinal Enrichment Supplementation Trials (CREST).…”

Role of Dietary Supplementation in Preventing Progression of Age-Related Macular Degeneration

“…И действительно, к настоящему времени накоплены данные о влиянии лютеина и зеаксантина на риск прогрессирования ВМД [19,20,21]. Лютеин и зеа-ксантин, а также другие антиоксиданты способствуют увеличению ОПМП и улучшению зрительных функций [22,23,24,25,26,27,28,29,30].…”