Effect of Lung Volume on Steady State Pulmonary Membrane Diffusing Capacity and Pulmonary Capillary Blood Volume<sup>1,</sup><sup>2</sup>

Sackner, Marvin A.; Raskin, Michael M.; Julien, Peter; Avery, Wilbur G.

doi:10.1164/arrd.1971.104.3.408

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…Our previous mean value for DL COSB at 1.4 l/min V O 2 in three individuals was 48 ml ⅐ min Ϫ1 ⅐ Torr Ϫ1 , so again it is possible that the discrepancy is due to exercise. Other workers have found DL COSS to be less than DL COSB (13). Dm COSS is close to our previous value for Dm COSB (316 ml ⅐ min Ϫ1 ⅐ Torr Ϫ1 ).…”

Section: Major Findingssupporting

confidence: 89%

Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men

Borland

Mist

Zammit

et al. 2001

Journal of Applied Physiology

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Using a rapidly responding nitric oxide (NO) analyzer, we measured the steady-state NO diffusing capacity (DL(NO)) from end-tidal NO. The diffusing capacity of the alveolar capillary membrane and pulmonary capillary blood volume were calculated from the steady-state diffusing capacity for CO (measured simultaneously) and the specific transfer conductance of blood per milliliter for NO and for CO. Nine men were studied bicycling at an average O(2) consumption of 1.3 +/- 0.2 l/min (mean +/- SD). DL(NO) was 202.7 +/- 71.2 ml. min(-1). Torr(-1) and steady-state diffusing capacity for CO, calculated from end-tidal (assumed alveolar) CO(2), mixed expired CO(2), and mixed expired CO, was 46.9 +/- 12.8 ml. min(-1). Torr(-1). NO dead space = (VT x FE(NO) - VT x FA(NO))/(FI(NO) - FA(NO)) = 209 +/- 88 ml, where VT is tidal volume and FE(NO), FI(NO), and FA(NO) are mixed exhaled, inhaled, and alveolar NO concentrations, respectively. We used the Bohr equation to estimate CO(2) dead space from mixed exhaled and end-tidal (assumed alveolar) CO(2) = 430 +/- 136 ml. Predicted anatomic dead space = 199 +/- 22 ml. Membrane diffusing capacity was 333 and 166 ml. min(-1). Torr(-1) for NO and CO, respectively, and pulmonary capillary blood volume was 140 ml. Inhalation of repeated breaths of NO over 80 s did not alter DL(NO) at the concentrations used.

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Section: Major Findingssupporting

confidence: 89%

Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men

Borland

Mist

Zammit

et al. 2001

Journal of Applied Physiology

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“…In the absence of a significant pulmonary or cardiac shunt, the pulmonary blood flow will equal cardiac output. Hoeper and colleagues (Hoeper et al 1999) showed that acetylene absorption measured by means of the rebreathing technique (Sackner et al 1975, Triebwasser et al 1977 can be used as an accurate measure for cardiac output in healthy subjects and idiopathic pulmonary arterial hypertension (iPAH) patients at rest. However, due to the need for expensive equipment such as the mass spectrometer this rebreathing technique has not been widely used.…”

Section: Introductionmentioning

confidence: 99%

Stroke volume response during exercise measured by acetylene uptake and MRI

et al. 2006

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The intra-breath technique to measure acetylene absorption offers the possibility to determine augmentation of the pulmonary blood flow per heart beat (Q(C)) as an estimate of the stroke volume response during exercise. However, this method has not been compared with a validated test until now. Therefore, the aim of this study was to compare Q(C) with stroke volume (SV(MRI)) determined by magnetic resonance imaging (MRI) at rest and during exercise in healthy subjects and patients. For this purpose, ten healthy subjects and ten patients with idiopathic pulmonary arterial hypertension (iPAH) with expected impaired stoke volume response during exercise were measured by both methods. Exercise-induced changes in Q(C) and SV(MRI) were correlated in healthy controls (r = 0.75, p < 0.05). Compared to healthy controls, Q(C) increased less during exercise in iPAH patients (11 +/- 17 ml versus 33 +/- 12 ml, p < 0.05). A similar difference in stroke volume response to exercise between the two groups was measured by MRI (-0.6 +/- 8 ml versus 23 +/- 12 ml, p < 0.05, respectively). Hence, intra-breath and MRI measurements showed similar differences in exercise-induced changes in stroke volume between controls and patients. From these results it can be concluded that the intra-breath measurement of acetylene absorption might be of value as a non-invasive tool to estimate stroke volume augmentation during exercise and can detect differences in stroke volume responses between iPAH patients and healthy subjects.

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Gas Exchange in Exercise

Cerretelli

Prampero

1987

Comprehensive Physiology

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Effect of Lung Volume on Steady State Pulmonary Membrane Diffusing Capacity and Pulmonary Capillary Blood Volume^1,²

Cited by 7 publications

References 12 publications

Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men

Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men

Stroke volume response during exercise measured by acetylene uptake and MRI

Gas Exchange in Exercise

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Effect of Lung Volume on Steady State Pulmonary Membrane Diffusing Capacity and Pulmonary Capillary Blood Volume1,2

Cited by 7 publications

References 12 publications

Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men

Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men

Stroke volume response during exercise measured by acetylene uptake and MRI

Gas Exchange in Exercise

Contact Info

Product

Resources

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Effect of Lung Volume on Steady State Pulmonary Membrane Diffusing Capacity and Pulmonary Capillary Blood Volume^1,²