Effect of Luffa aegyptiaca (seeds) and Carissa edulis (leaves) extracts on blood glucose level of normal and streptozotocin diabetic rats

Hypoglycemic effect of Acosmium panamense bark on streptozotocin diabetic rats

“…STZ administration at a dosage of 50 mg/kg bw to normal rats significantly elevated the blood glucose levels compared with rats injected citrate buffer alone as reported for albino rats (El-Fiky et al, 1996).…”

Anti-diabetic activity ofEmblica officinalisin animal models

“…Diabetes was induced by a single intraperitoneal injection of freshly prepared streptozotocin (STZ) 50 mg kg −1 (Sigma-Aldrich, Seelze, Germany) in 0.1 M citrate buffer (pH = 4.5) (El-Fiky et al, 1996) to rats deprived of food overnight. After 3 days of STZ administration, rats with marked hyperglycemia were selected for the study (Rai et al, 2008).…”

Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats

“…In order to discover other hypoglycaemic agents, many investigations have been performed in traditional medicine testing eventual hypoglycaemic naturals (Keenoy et al, 2005;Bonnefont et al, 2004). Among animal models of diabetes mellitus, streptozotocin rat was considered especially as a precious tool to study both pathophysiological mechanisms of diabetes mellitus and hypoglycaemic activity of natural products (El Fiky et al, 1996). Streptozotocin was recognised as a toxic agent for B-cells of the islets of Langerhans (Agarwal 1980), and has since then been widely used for the induction of diabetes mellitus with concomitant insulin deficiency (Bolzán and Bianchi, 2002).…”