Effect of &lt;i&gt;Piper betle&lt;/i&gt; extract on anti-candidal activity, gelation time, and surface hardness of a short-term soft lining material

Kumpanich, Juthatip; Eiampongpaiboon, Trinuch; Kanchanavasita, Widchaya; Chitmongkolsuk, Somsak; Puripattanavong, Jindaporn

doi:10.4012/dmj.2019-314

Cited by 4 publications

(6 citation statements)

References 23 publications

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“…Essential oils and ethanolic extract from leaves showed potential antifungal activity against Candida albicans . 182 , 183 , 184 Complete inhibition of Aspergillus flavus fungal mycelia 185 by ethanol extract and inhibition of Candida tropicalis 166 were also observed in two different experiments. Essential oil, methanolic and aqueous leaf extracts of betel against Candida albicans and Malassezia pachydermatis 167 and leaf extract by hydrodistillation against Saccharomyces cerevisiae and Candida albicans 169 exhibited significant antifungal activity.…”

Section: Antimicrobial Activitiesmentioning

confidence: 81%

“…Antifungal activityVarious preclinical studies proved the antifungal potential of P. betle against a number of fungi by different solvent extracts.Essential oils and ethanolic extract from leaves showed potential antifungal activity against Candida albicans [182][183][184]. Complete inhibition of Aspergillus flavus fungal mycelia185 by ethanol extract and inhibition of Candida tropicalis166 were also observed in two different experiments.…”

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confidence: 99%

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Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Biswas

Anand

Saha

et al. 2022

J Cellular Molecular Medi

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Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart‐shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also used for religious purposes. Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P . betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many more. Immense attention has been paid to nanoformulations and their applications. The application of P . betle did not show cytotoxicity in preclinical experiments, suggesting that it could serve as a promising therapeutic candidate for different diseases. The present review comprehensively summarizes the botanical description, geographical distribution, economic value and cultivation, ethnobotanical uses, preclinical pharmacological properties with insights of toxicological, clinical efficacy, and safety of P . betle . The findings suggest that P . betle represents an orally active and safe natural agent that exhibits great therapeutic potential for managing various human medical conditions. However, further research is needed to elucidate its underlying molecular mechanisms of action, clinical aspects, structure–activity relationships, bioavailability and synergistic interactions with other drugs.

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Section: Antimicrobial Activitiesmentioning

confidence: 81%

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confidence: 99%

Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Biswas

Anand

Saha

et al. 2022

J Cellular Molecular Medi

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“…Moreover, the longer gelation time also affect the hardness of GC soft liner. The study showed that the hardness of 10% w/w PBC incorporated into GC soft liner at 2-hr and 7-day incubation time was 13.44 ± 1.53 and 21.98 ± 1.40, respectively [8]. However, according to ISO:10139-1:2018 standard, the hardness of soft material should be within a 30-50 units at 2-hr incubation time, and should not exceed 60 units at 7-day incubation time, while the hardness of extra soft material should be lower than 30 units at 2-hr incubation time and 60 units at 7-days incubation time [26].…”

Section: Discussionmentioning

confidence: 98%

“…Piper betle (Piperaceae) is a traditional herb that contains various pharmacological properties, such as anti-microbial, anti-oxidant, anti-carcinogenic, and antiinflammatory effects [7]. Kumpanich et al reported that Piper betle crude extract (PBC) can be used as an additive in the denture soft liner with the optimum composition of 5% w/w against Candida albicans [8]. Clinical application of PBC is still somewhat restricted due to its dark green color and difficulty in preparation.…”

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confidence: 99%

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Anti-microbial effect of Piper betle crude extract and essential oil incorporated into short-term soft lining material

Poolkerd,

Nagaviroj,

Srisatjaluk

et al. 2023

jos

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Introduction:Using soft lining material to treat denture stomatitis for an extended period of time may result in oral bacterial and fungal accumulations. Several additives, including natural products, have been identified as antimicrobial agents. Objectives:The aim of the present study was to evaluate the anti-microbial activity of Piper betle crude extract (PBC) and Piper betle essential oil (PBO) incorporated into soft liner with different concentrations against Candida albicans and Streptococcus mutans. Cytotoxicity of various additives applied into soft lining material was also investigated. Material and methods: Anti-microbial activity of PBC and PBO were assessed using agar disc diffusion method. Agar well diffusion method was also applied to evaluate inhibitory effect of PBC and PBO incorporated into soft lining material. Cell viability of human gingival fibroblast (HGF) cell line after exposing to soft lining materials with PBC was investigated. Results: With the same minimum inhibitory concentration (MIC) of 2.5% w/w, PBC showed anti-fungal and anti-bacterial activities against C. albicans and S. mutans. However, PBO had a 2.5% v/v MIC against C. albicans, but a 10% v/v MIC against S. mutans. Accordingly, GC soft liner with PBC had MICs of 5% w/w against C. albicans and 10% w/w against S. mutans, whereas GC soft liner with PBO had MICs of 20% v/v and 60% v/v against C. albicans and S. mutans, respectively. Statistical analysis revealed that there was no significant difference in cell viability among GC soft liner, with 5% and 10% w/w PBC and GC soft liner without additive (p > 0.05). Conclusions: Both PBC and PBO showed anti-bacterial and anti-fungal activity; however, the 10% w/w PBC incorporated into GC soft liner demonstrated the optimal concentration to serve as an anti-microbial agent against both C. albicans and S. mutans, with no toxicity to HGF cells.

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Biofilm inhibition of denture cleaning tablets and carvacrol on denture bases produced with different techniques

Sahin,

Ozer,

Calı

2024

Clin Oral Invest

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Objectives This study compares the biofilm inhibition effects of denture cleaning tablets, carvacrol, and their combined use against Candida albicans on denture bases produced with different techniques. Additionally, the surface roughness and contact angles of these denture bases were evaluated. Materials and methods Test samples were prepared from four different denture base materials (cold-polymerized, heat-polymerized, CAD/CAM milling, and 3D-printed). The surface roughness and contact angles of the test samples were measured using a profilometer and goniometer, respectively. For the evaluation of biofilm inhibition, samples were divided into 5 subgroups: Corega and carvacrol, separately and combined treatments, positive (inoculated with C. albicans) and negative control (non-inoculated with C. albicans, only medium). Biofilm mass was determined using the crystal violet method. An additional prepared test sample for each subgroup was examined under scanning electron microscopy (SEM). Results The surface roughness values of the 3D-printed test samples were found to be statistically higher than the other groups (P < .001). The water contact angle of all test materials was not statistically different from each other (P > .001). Corega and carvacrol, separately and combined, significantly decreased the amount of biofilm on all surfaces (P < .0001). Treatment of corega alone and in combination with carvacrol to the 3D-printed material caused less C. albicans inhibition than the other groups (P < .001; P < .05). Conclusions The surface roughness values of all test groups were within the clinically acceptable threshold. Although Corega and carvacrol inhibited C. albicans biofilms, their combined use did not show a synergistic effect. Clinical relevance Carvacrol may be used as one of the disinfectant agents for denture cleaning due to its biofilm inhibition property.

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Effect of <i>Piper betle</i> extract on anti-candidal activity, gelation time, and surface hardness of a short-term soft lining material

Cited by 4 publications

References 23 publications

Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Anti-microbial effect of Piper betle crude extract and essential oil incorporated into short-term soft lining material

Biofilm inhibition of denture cleaning tablets and carvacrol on denture bases produced with different techniques

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