Effect of &lt;i&gt;Garcinia Conrauana&lt;/i&gt; Ingestion in Adult Nigerian Asthmatics

Ebomoyi, MI; Iyawe, V. I.; Egbagbe, EE

doi:10.4314/njhbs.v3i1.11502

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“…Studies have shown that many plant materials used as food have some medicinal activities (Gbile and Adesina, 1989;Odebiyi and Sofowora, 1993). Disease treatment and prevention, in Nigeria, have for a long time been handled by traditional healers (Ebomoyi et al, 2004). Their practice involves the use of herbs, animals, mineral substances or the use of rituals and incantations.…”

Section: Introductionmentioning

confidence: 99%

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Effect of oral administration of aqueous extract of cassia occidentalis l. seeds on serum electrolytes concentration in rats

Abubakar¹,

Sule²

2010

Bayero J. Pure App. Sci.

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The effect of aqueous extract of C. occidentalis seeds on serum electrolytes concentration, in rats, was investigated in order to assess the acclaimed hypotensive effect of the seeds and also the seeds extract's relation with acid -base balance of the body. Serum concentrations of sodium, potassium, chloride and bicarbonate ions were determined in 64 rats grouped into 4. Groups I, II and III rats were orally administrated with the seeds extract at a daily dose of 30 mg/kg, 60 mg/kg and 90 mg/kg respectively for 1,2,3 and 4 weeks each. Group IV served as control. Concentration of sodium, potassium, chloride and bicarbonate in the serum of control rats were found to range from 130 -155 mEq/L, 3.4 -8.7 mEq/L, 80 -107 mmol/L and 20 -35 mmol/L respectively. The results of this study showed no significant difference (P<0.01) when serum sodium, chloride and bicarbonate levels in the rats orally administered with 30 mg/kg for 1 -2 weeks were compared with control rats . However, there was significant increase (P<0.01) in serum potassium levels at 3 rd and 4 th weeks of experiment. Oral administration of aqueous extract of C. occidentalis seeds at a daily dose of 60 mg/kg was found to show significant increase (P<0.01) in serum potassium level and a significant decrease (P<0.05) in serum sodium levels irrespective of duration of administration (weeks). This indicates that the seeds extract have hyperkalaemic and hyponatremic effect at a daily dose of 60 mg/kg and as such can have hypotensive effect at this dose. Serum levels of chloride and bicarbonate showed significant decrease (P<0.01) when the daily dose is 90 mg/kg for > 1 week. This indicates that the seeds extract dosage of 90 mg/kg could lead to disturbance in acid-base balance.

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Section: Introductionmentioning

confidence: 99%

“…Their practice involves the use of herbs, animals, mineral substances or the use of rituals and incantations. The use of herbs, however, survived best (Ebomoyi et al, 2004). Medicinal plants are believed to be important sources of new chemical substances with potential therapeutic effects (Farnsworth, 1989).…”

Section: Introductionmentioning

confidence: 99%

Effect of oral administration of aqueous extract of cassia occidentalis l. seeds on serum electrolytes concentration in rats

Abubakar¹,

Sule²

2010

Bayero J. Pure App. Sci.

View full text Add to dashboard Cite

show abstract

Effect of <i>Garcinia Conrauana</i> Ingestion in Adult Nigerian Asthmatics

Cited by 1 publication

References 0 publications

Effect of oral administration of aqueous extract of cassia occidentalis l. seeds on serum electrolytes concentration in rats

Effect of oral administration of aqueous extract of cassia occidentalis l. seeds on serum electrolytes concentration in rats

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