Effect of <i>Achyranthes bidentata</i> Blume extract on carrageenan-induced chronic prostatitis in rats

Abstract

Purpose: To investigate the effect of Achyranthes bidentata Blume. Extract (ABBE) on carrageenaninduced chronic prostatitis in rats. Methods: Experimental chronic non-bacterial prostatitis (CNP) was induced in rats by 1 % carrageenan (0.1 mL). Prostate index (PI) and prostate specific antigen (PSA) were determined after 3 weeks of adiministration. Relative inflammatory factors, viz, tumor necrosis factor-α (TNF-α), interleukin1β (IL-1β), cyclooxygenase-2 (COX-2), prostaglandin E2 (PEG2), transforming growth factor-β1 (TGF-β1) and

Phenolic constituents from Alisma plantago-aquatica Linnaeus and their anti-chronic prostatitis activity

“…Rats in drug-treated groups were administered the isolated compounds ( 1 – 5 ) or cernilton (positive control, i.e., reference standard) for 3 weeks while rats in normal and negative control groups were treated with saline at the same time. After treatment, the relative inflammatory factors, tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), cyclooxygenase-2 (COX-2), prostaglandin E2 (PEG2), and transforming growth factor-β1 (TGF-β1) of the prostate tissues were measured by ELISA [2, 4]. …”

“…Administered cernilton, both groups for 3 weeks. Rats of normal and negative control groups were administered saline at the same time [2, 4]. …”

“…Cernilton is one of the most widely used drugs for treating chronic non-bacterial prostatitis, but has not achieved significant curative effect in clinic. Recently, more herbal medicine has being used as alternative therapy for prostatitis [1, 2, 4–6]. Due to its natural constituent and availability, natural herbs which obtained from natural sources are believed to provide less untoward effect profiles and provide greater effectiveness as compared to synthetic drug available over the market.…”