Effect of low oxygen conditions on matrix metalloproteinase-9 production of macrophages subjected to cyclic stretching: involvement of ERK and Rho kinase pathways
Abstract:Macrophages infiltrated in the walls of abdominal aortic aneurysms (AAA) are subjected to cyclic stretching due to pulsatile deformation of blood vessels and low oxygen conditions caused by intraluminal thrombus. These conditions could induce aberrant changes in macrophage functions and lead local weakening of AAA walls. We previously reported that the combination of 10 % cyclic stretching and 2.2% O 2 conditions caused an increase in matrix metalloproteinase-9 (MMP-9) production in macrophages as well as chan… Show more
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