Effect of low-level laser therapy on repair of the bone compromised by radiotherapy

Batista, Jonas Dantas; Zanetta‐Barbosa, Darceny; Cardoso, Sérgio Vitorino; Dechichi, Paula; Rocha, Flaviana Soares; Pagnoncelli, Rogério Miranda

doi:10.1007/s10103-014-1602-8

Cited by 30 publications

(20 citation statements)

References 37 publications

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“…The 30 Gy used in the present study was based in previous studies, which showed that a single high dose of IR led to bone damage, which allowed the effect of irradiation on bone to be evaluated [3, 21]. The fractionated irradiation protocol, recommended for use in human radiotherapy, is complex to perform in animal models.…”

Section: Discussionmentioning

confidence: 99%

Ionizing radiation and bone quality: time-dependent effects

et al. 2019

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BackgroundThe aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation.MethodsWistar rats were submitted to IR (30 Gy) on the left leg and were euthanized after 30 and 60 days. The legs were divided into four groups according to the treatment and euthanization time: C30 and C60 (right leg–without IR), IR30 and IR60 (left leg-with IR).ResultsCT analysis showed more radiodensity in C60 compared with other groups, and IR60 showed more radiodensity than IR30. In histomorphometric analysis, C30 showed lower bone matrix values compared with IR30 and C60. Lacunarity analyses showed more homogeneous bone channel distribution in C30 than IR30. ATR-FTIR showed decrease in ratio of mature and immature crosslinks in IR30 compared with C30. Crystallinity Index was decrease in IR60 compared with C60. The Amide III + Collagen/HA ratio was increased in C60 compared with C30; however this ratio decreased in IR60 compared with IR30. Biomechanical analysis showed lower values in IR groups in both time.ConclusionsIR damaged bone quality and decreased stiffness. Moreover, the results suggested that the deleterious effects of IR increased in the late time points.

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Section: Discussionmentioning

confidence: 99%

Ionizing radiation and bone quality: time-dependent effects

et al. 2019

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“…In contrast, an in vivo study found that PBM was not able to reverse RT-induced bone damage [97]. To our knowledge, there are no clinical studies on the effects of PBM for RT-induced jaw osteonecrosis.…”

Section: Pbm For the Management Of Orofacial And Neck Complications Omentioning

confidence: 99%

Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols

Zecha

Raber-Durlacher

Nair

et al. 2016

Support Care Cancer

195

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Purpose There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT), more recently termed photobiomodulation (PBM) for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved and dosimetric parameters may lead to the management of a broader range of complications associated with HNC treatment. This could enhance patient adherence to cancer therapy, and improve quality of life and treatment outcomes. The mechanisms of action, dosimetric, and safety considerations for PBM have been reviewed in part 1. Part 2 discusses the head and neck treatment side effects for which PBM may prove to be effective. In addition, PBM parameters for each of these complications are suggested and future research directions are discussed. Methods Narrative review and presentation of PBM parameters are based on current evidence and expert opinion. Results PBM may have potential applications in the management of a broad range of side effects of (chemo)radiation therapy (CRT) in patients being treated for HNC. For OM management, optimal PBM parameters identified were as follows: wavelength, typically between 633 and 685 nm or 780–830 nm; energy density, laser or light-emitting diode (LED) output between 10 and 150 mW; dose, 2–3 J (J/cm2), and no more than 6 J/cm2 on the tissue surface treated; treatment schedule, two to three times a week up to daily; emission type, pulsed (<100 Hz); and route of delivery, intraorally and/or transcutaneously. To facilitate further studies, we propose potentially effective PBM parameters for prophylactic and therapeutic use in supportive care for dermatitis, dysphagia, dry mouth, dysgeusia, trismus, necrosis, lymphedema, and voice/speech alterations. Conclusion PBM may have a role in supportive care for a broad range of complications associated with the treatment of HNC with CRT. The suggested PBM irradiation and dosimetric parameters, which are potentially effective for these complications, are intended to provide guidance for well-designed future studies. It is imperative that such studies include elucidating the effects of PBM on oncology treatment outcomes.

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“…1 Compared to laser, NIR LED light has gained more attention for its ability to activate anti-in°ammatory processes and is now widely used in veterinary medicine to treat sprains, bone fractures, and to speed the healing of wounds. 3 Over the last 10 years, there has been a lot of studies focusing on whether the transcranial NIR LED light has a regulatory e®ect on electrical activity in the brain, and results from these studies have shown the neuromodulatory e®ect of transcranial NIR. 4 Nevertheless, the light-source type is not the only parameter that must be considered when using PBM.…”

Section: Introductionmentioning

confidence: 99%

Effects of stimulating frequency of NIR LEDs light irradiation on forehead as quantified by EEG measurements

Yao

Qian

Liu

et al. 2020

J. Innov. Opt. Health Sci.

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Near-infrared (NIR) light has been shown to produce a range of physiological effects in humans, however, there is still no agreement on whether and how a single parameter, like the flicker frequency of NIR light, affects the brain. Methods: An 810[Formula: see text]nm NIR LED was used as the stimulator. Fifty subjects participated in this experiment. Forty subjects were randomly divided into four groups. Each group underwent a 30-minute NIR LED radiation with four different frequencies (i.e., 0[Formula: see text]Hz, 5[Formula: see text]Hz, 10[Formula: see text]Hz and 20[Formula: see text]Hz, respectively) on the forehead. The remaining 10 subjects formed the control group, in which they underwent a 30-minute rest period without light radiation. EEG signals of all subjects during each test were recorded. Gravity frequency (GF), relative energy change, and sample entropy were analyzed. Results: The experimental groups had larger GF values compared to the control group. Higher stimulation frequency would cause larger growth of GF ([Formula: see text], [Formula: see text]). The amplitude of alpha waves relative energy increased, while theta waves decreased remarkably in the experimental groups ([Formula: see text]), and the extent of increase/decrease was larger at higher stimulation frequency, compared to that of the control. Sample entropy of electrodes in the frontal areas were much larger than those in other brain areas in the experimental groups ([Formula: see text]). Conclusions: Larger frequency of the NIR LED light would cause more distinct brain activities in the stimulated areas. It indicates that NIR LED light may have a positive effect on modulating brain activity. These results may help improve the design of photobiomodulation treatments in the future.

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Effect of low-level laser therapy on repair of the bone compromised by radiotherapy

Cited by 30 publications

References 37 publications

Ionizing radiation and bone quality: time-dependent effects

Ionizing radiation and bone quality: time-dependent effects

Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols

Effects of stimulating frequency of NIR LEDs light irradiation on forehead as quantified by EEG measurements

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