Effect of low‐level laser therapy on chemoradiotherapy‐induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients

Oton-Leite, Angélica Ferreira; Silva, Geisa Badauy L.; Morais, Marília Oliveira; Silva, Tarcı́lia Aparecida; Leles, Cláudio Rodrigues; Valadares, Marize Campos; Pinezi, Juliana Castro Dourado; Batista, Aline Carvalho; Mendonça, Elismauro Francisco

doi:10.1002/lsm.22349

Cited by 84 publications

(56 citation statements)

References 49 publications

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“…contribution to the reduction of inflammation and severity of oral mucositis in patients with head and neck cancer undergoing simultaneously radiotherapy and chemotherapy 42 . In addition, another study evaluated the efficacy of laser in the prevention of oral mucositis in patients undergoing chemotherapy and radiotherapy, as well as in the prevention of painful symptoms associated with this condition.…”

Section: Resultsmentioning

confidence: 99%

Immunopathogenesis of Oral Mucositis Induced by Chemotherapy and/or Radiotherapy: State of Art

Dantas

Martins

Lima³

et al. 2017

BJMHH

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| Introduction:Oral mucositis is a common and worrying clinical condition in patients undergoing radiotherapy of the head and neck regions and aggressive chemotherapy. Mucosits manifests as a continuous process, which begins with erythematous and atrophic lesions that can progress to very painful ulcers. The immunopathogenesis of oral mucositis is considered a complex cascade of biological events, and advances on its understanding might result in promising and effective therapies. Objectives: The aim of this study is to highlight the recent findings of the immunopathogenesis of oral mucositis induced by chemotherapy and / or radiotherapy and their possible therapeutic agents. Material and methods: Scientific articles were selected in Pubmed and LILACS basis from December 2015 to May 2016, using the key words in English "mucositis etiopathogenesis" and "mucositis". Were found in Pubmed 107 articles and LILACS 61. The articles were selected after reading and were chosen those which reported detail on the immunopathology of oral mucositis, and an update on the biological causes of this clinical condition. Results and conclusion: The literature indicates that histopathological changes related to oral mucositis, including apoptotic phenomenon, the action of certain chemical mediators and the influence of the oral cavity microbiota promote a better understanding of the immunopathogenesis of this type of injury and their biological development. Therefore, additional clinical studies based on scientific evidence are needed to get a better understanding of the immunopathology of oral mucositis and the determination of preventive agents and effective therapeutic for this deleterious effect arising from antineoplastic treatment.

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Section: Resultsmentioning

confidence: 99%

Immunopathogenesis of Oral Mucositis Induced by Chemotherapy and/or Radiotherapy: State of Art

Dantas

Martins

Lima³

et al. 2017

BJMHH

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“…In a randomized placebo controlled trial conducted by Gantam et al on a group of 46 elderly patients with radiation induced oral mucositis, PBM decreased the severity of oral mucositis and also reduced usage of analgesics [52]. Another randomized placebo controlled trial, which was conducted by Oton-Leite et al on a group of 30 patients with head and neck cancer, resulted in the conclusion that PBM was effective in reducing the severity of chemoradiotherapy-induced oral mucositis [53]. A randomized placebo controlled trial which was conducted by Antunes et al on a group of 94 patients also proved that PBM is effective in preventing chemoradiotherapy-induced oral mucositis and improves quality of life [54].…”

Section: Management Of Oral Mucositismentioning

confidence: 99%

“…A summary of randomized double-blind studiesincluding cryotherapy, photobiomodulation (PBM), and usage of palifermin or caphosol is presented in Table 5. [44] 145 patients Prospective randomized study Cryotherapy Kamsvåg T et al (2020) [45] 49 patients Randomized study Cryotherapy Gantam et al (2015) [52] 46 patients Randomized study PBM Oton-Leite et al (2015) [53] 30 patients Randomized study PBM Antunes et al (2013) [54] 94 patients Randomized study PBM Henke et al (2011) [61] 186 patients Randomized study Palifermin Le et al (2011) [62] 94 patients Randomized study Palifermin Raphael et al (2014) [66] 29 patients Randomized study Caphosol…”

Section: Management Of Oral Mucositismentioning

confidence: 99%

Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem—Literature Review

Kusiak

Jereczek‐Fossa

Cichońska

et al. 2020

IJERPH

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Oral mucositis is a toxic side effect of non-surgical cancer treatments: chemotherapy and radiotherapy, which strongly impair quality of life and can not only cause strong pain, but also lead to problems with basic physiological needs as eating and swallowing. Development of oral mucositis is associated with type, dosage, and schedule of radiation or chemotherapy and other factors related to patients. Management of oral mucositis is a valid problem, requiring topical application of anesthetics, coating agents, cryotherapy, low level laser therapy, pharmacological methods as usage of keratinocyte growth factors, supplementation of vitamins, and a proper diet. Another approach to oral mucositis measurement includesphotobiomodulation, which brings analgesic and anti-inflammatory effects.Although oral mucositis is a general health issues, the role of proper dental care is essential. It should include elimination of all potential sources of mucosal injury and microorganisms inhabiting theoral cavity through oral hygiene education, professional management ofdental plaque, and treatment of the caries and periodontium, which are necessary to reduce the risk of inflammation in the oral cavity. This paper describes the possibilities of monitoring oral mucositis, taking into account the latest therapeutic achievements.

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“…Devido à diversidade de aparelhos disponíveis no mercado, com diferentes potências e comprimento de onda variável, ainda não existe um protocolo definido para sua utilização. Novos estudos precisam ser realizados na tentativa de se estabelecer um protocolo fixo de aplicação do laser, para que, dessa maneira, possa ser incorporado nas equipes oncológicas 27 .…”

Section: Mucosite Oralunclassified

Repercussões orais de drogas antineoplásicas: uma revisão de literatura

Jesus

Cicchelli

Martins

et al. 2016

Rev. da Fac. de Odontologia, UPF

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RESUMO: O abuso no consumo de drogas tem sido considerado um grave problema de saúde pública, já que os usuários mudam seu comportamento e se descuidam da saúde geral e bucal. Desta forma, o sistema estomatognático dos usuários de drogas apresenta diversas lesões causadas por essas substâncias químicas. Este estudo tem por objetivo demonstrar as manifestações orais consequentes do uso abusivo de drogas ilícitas por meio de uma revisão literatura narrativa, afim de mostrar a importância do cirurgião-dentista na equipe multidisciplinar de tratamento desses indivíduos. Ao término desta revisão foi possível evidenciar alterações bucais como: redução do fluxo salivar, cárie e doença periodontal. PALAVRAS-CHAVE: Dependentes químicos. Saúde bucal. Alterações bucais em dependentes químicos. ABSTRACT: Drug abuse has been considered a serious public health problem, as users change their behavior and neglect general and oral health. In this way, the stomatognathic system of drug users presents diverse lesions caused by these chemical substances. This study aims to demonstrate the consequent oral manifestations of abusive use of illicit drugs through a narrative literature review, in order to show the importance of the dental surgeon in the multidisciplinary team of treatment of these individuals. At the end of this review it was possible to show that oral alterations such as: reduction of salivary flow, caries and periodontal disease are some of the main oral aspects present in illicit drug users.

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Effect of low‐level laser therapy on chemoradiotherapy‐induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients

Abstract: These findings demonstrated that LLLT was effective in reducing the severity of chemoradiotherapy-induced OM and was associated with the reduction of inflammation and repair.

Cited by 84 publications

References 49 publications

Immunopathogenesis of Oral Mucositis Induced by Chemotherapy and/or Radiotherapy: State of Art

Immunopathogenesis of Oral Mucositis Induced by Chemotherapy and/or Radiotherapy: State of Art

Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem—Literature Review

Repercussões orais de drogas antineoplásicas: uma revisão de literatura

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