Effect of Low Intensity Laser Therapy (LILT) on MMP-9 expression in gingival crevicular fluid and rate of orthodontic tooth movement in patients undergoing canine retraction: A randomized controlled trial

Jivrajani, Sagar J.; Bhad, Wasundhara A.

doi:10.1016/j.ortho.2020.01.008

Cited by 13 publications

(11 citation statements)

References 23 publications

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“…Also, in the study by Caccianiga et al [ 39 ], the same laser device as that employed in our trial has been used, with the same 980 nm wavelength, and positive biostimulation has been reported. Effective biostimulation with the 980 nm wavelength has been also reported by Jivrajani and Bhad-Patil [ 44 ], as well as Abtahi et al [ 45 ].…”

Section: Discussionmentioning

confidence: 62%

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

et al. 2022

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Background Controversial results have been reported regarding the impact of photobiomodulation (PBM) on orthodontically induced inflammatory root resorption (OIIRR). The aim of this study was to evaluate the influence of two PBM protocols, one of them requiring a high application frequency (on days 0, 3, 7, 14, then every 2 weeks), while the second requires less frequent applications (every 3 weeks), on OIIRR accompanying orthodontic treatment. Methods Twenty female patients were recruited for this randomized controlled trial, requiring the therapeutic extraction of maxillary first premolars, and they were randomly divided into 2 equal groups. In Group A, one side of the maxillary arch randomly received PBM on days 0, 3, 7, 14, and every 2 weeks thereafter, while in Group B, one side was randomly chosen to receive PBM every 3 weeks. The laser applied was a Diode laser with a wavelength of 980 nm, in a continuous mode. Canine retraction in both groups was carried out using closed-coil springs, delivering 150 g of force, and the force level was checked every 3 weeks, over a 12-week study period. Pre-retraction and post-retraction cone-beam computed tomography (CBCT) was done for the evaluation of OIIRR. Results No significant differences in the amount of OIIRR have been reported between the laser and control sides in both groups A and B. Also, no significant differences have been reported between the laser sides in both groups. Conclusions Photobiomodulation does not affect OIIRR, whether by increasing or decreasing its occurrence, with both laser application protocols. Therefore, it can be stated that PBM does not result in root resorption less than the commonly observed range elicited with conventional orthodontic treatment, and that it has no effect on OIIRR. Trial registration Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction (NCT04926389), 15/06/2021—retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT04926389.

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Section: Discussionmentioning

confidence: 62%

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

et al. 2022

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“…The tooth movement acceleration was evaluated as the outcomes in 25 articles. [ 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 ] The pain reduction was assessed in 40 experiments. [ 18 20 , 21 23 , 24 28 , 37 38 39 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 ] Only five articles evaluated the impact of LLLT on root resorption.…”

Section: R Esultsmentioning

confidence: 99%

“…The acceleration of tooth movement could be evaluated by measuring the moving distance during the canine retraction or the duration of complete treatment for decrowding. The tooth movement could be measured in an oral cavity,[ 19 26 ] on dental casts[ 17 18 , 20 21 22 23 25 , 27 28 , 30 31 32 33 35 , 39 ] or digital models[ 24 36 37 38 , 40 41 ] by using a digital caliper or stereomicroscope with appropriate reference points. Irregularity index representing horizontal overlapping or crowding can also be used for the evaluation.…”

Section: R Esultsmentioning

confidence: 99%

“…[ 22 ] Six experiments additionally collected gingival crevicular fluid (GCF) to analyze tooth movement-related substance, including IL-1β, TGF-β1, PGE 2 , MMP-9, OPG, OPN, and RANKL. [ 19 25 , 29 33 , 34 41 ]…”

Section: R Esultsmentioning

confidence: 99%

“…The data summarized in Tables 1 – 3 of this review were analyzed from 60 articles listed in the reference section. [ 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 ]…”

Section: Onclusionmentioning

confidence: 99%

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The Protocol of Low-level Laser Therapy in Orthodontic Practice

Sipiyaruk¹,

Chintavalakorn²,

Saengfai³

2022

Journal of International Society of Preventive and Community Dentistry

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A BSTRACT Low-level laser therapy (LLLT) has been widely investigated as an adjunct technique for orthodontic treatment due to photobiomodulation effect. LLLT appears to be supportive for an orthodontic practice in terms of tooth movement acceleration, pain relief, and root resorption management. The decrease in these adverse effects will enhance the compliance in orthodontic patients, which could positively impact treatment outcomes. However, there seemed to be inconsistency in the impact of LLLT as well as its laser and treatment parameters. This scoping review aimed to evaluate the impact of different irradiation parameters on tooth movement acceleration, pain relief, and root resorption as well as to construct a protocol of LLLT in orthodontic practice. The search was conducted across PubMed, Scopus, Web of Science, Embase, Google Scholar, and the reference lists of identified articles. The last search was conducted on October 10, 2021 to identify experiments in humans regarding the application of LLLT as noninvasive treatment in orthodontic practice published between 2010 and 2021. However, they were excluded if they were not clinical research, if they did not report the source of laser, or if they were not relevant to tooth movement, pain perception, and root resorption, or if they were not available in English or in full-text. Following the systematic search and selection process, 60 articles were included in this review. A majority of included articles were published in the past few years. The findings of this review supported the application of LLLT in orthodontic practice with purposes of tooth movement acceleration and pain reduction. The positive impact of LLLT on root resorption had not been clearly evident yet. As this review demonstrated heterogeneity of both laser and treatment parameters, further research should be required to ensure the effectiveness of its specific parameters in orthodontic practice.

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Effect of low-level laser therapy on en masse retraction in females with bimaxillary dentoalveolar protrusion

Dehis,

El Sharaby,

Eid

et al. 2024

J Orofac Orthop

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Background Acceleration of tooth movement has gained remarkable attention during the last decade. The aim of this study was to evaluate the effect of low-level laser therapy (LLLT) on en masse retraction of upper anterior teeth in adult women with bimaxillary dentoalveolar protrusion. Materials and methods In this two-arm parallel trial, 36 women with bimaxillary dentoalveolar protrusion were randomly divided into two equal groups. Eligibility criteria included class I Angle molar relationship, good general and oral health as well as no systemic disease or syndrome. Four temporary anchorage devices (TADs) were used in the upper and lower arches for anchorage purposes. A 0.019×0.025-inch stainless steel wire with crimped hooks just distal to the maxillary canines was inserted. Nickle titanium (NiTi) closed coil springs (200 g/side) were employed for en masse retraction following extraction of the first premolars. In the laser group (LG), retraction of the upper anterior teeth was done along with the application of LLLT on days 0, 3, 7, and 14 after extraction and then repeated biweekly until the end of retraction. Retraction was completed without LLLT application in the nonlaser group (NLG). Data concerning the rate of retraction as well as first molars and anterior positional changes were gained from digitized models and cone beam computed tomography (CBCT) scans taken just before extraction and at the end of retraction. Treatment-associated pain and root resorption were evaluated using visual analogue scale (VAS) and CBCT scans, respectively. Results Four patients dropped out prior to follow-up. The duration of retraction was 10.125 ± 2.876 and 13.643 ± 3.455 months in the LG and NLG, respectively. The LG showed a statistically significant faster rate of en masse retraction (0.833 ± 0.371 mm/month) compared to the NLG (0.526 ± 0.268 mm/month; P ≤ 0.035). The observed root resorption was significantly less in the LG (P ≤ 0.05) with comparable pain scores in both groups. Conclusions Within the constraints of the parameters of the LLLT used in the current study and despite the statistically significant results on the rate of en masse retraction and the associated root resorption, LLLT did not demonstrate a clinically relevant effect that justifies its use to enhance en masse retraction. Name of the registry Clinicaltrials.gov Trial registration number NCT05183451 Date of registration January 10, 2022, “Retrospectively registered” URL of trial registry record https://www.clinicaltrials.gov/study/NCT05183451

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Effect of Low Intensity Laser Therapy (LILT) on MMP-9 expression in gingival crevicular fluid and rate of orthodontic tooth movement in patients undergoing canine retraction: A randomized controlled trial

Cited by 13 publications

References 23 publications

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial)

The Protocol of Low-level Laser Therapy in Orthodontic Practice

Effect of low-level laser therapy on en masse retraction in females with bimaxillary dentoalveolar protrusion

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