Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study

Zhang, Yingfeng; Liu, Zhipeng; Duan, Lili; Ji, Yeyu; Yang, Sen; Zhang, Yuan; Li, Hongyin; Wang, Yu; Wang, Peng; Chen, Jiepeng; Liu, Ying

doi:10.1007/s00223-020-00669-4

Cited by 19 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this scenario, vitamin K2 was recently identified as a family of promising fat-soluble natural compounds necessary for bone health [ 31 ]. Indeed, its capacity to reduce loss of bone mass and risk of fractures thorough their action as a cofactor of the enzyme γ-glutamyl carboxylase (GGCX) [ 32 ] has been widely demonstrated [ 13 , 14 , 15 , 33 ]. However, the exact role of vitamin K2 in bone disorders, such as osteoporosis, is poorly understood [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nutrients 2021, 13, 2823 2 of 17 Among all possible osteo-protective compounds, vitamin K2 is noteworthy [6], a family of different isoforms, known as menaquinones (MKs), which differ from each other by the number of isoprenoid units in the side chain (n = 1-14), and in the last few years, they have received attention for their positive effects in bone metabolism [7][8][9][10][11]. Although its beneficial role in decreasing bone loss and risk of osteoporotic fractures has been established [12][13][14][15], additional studies are needed to deeply understand if vitamin K2 intake would provide a valid support to prevent and treat osteoporosis or if some people may be refractory to its effects.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2

et al. 2021

View full text Add to dashboard Cite

Several natural compounds, such as vitamin K2, have been highlighted for their positive effects on bone metabolism. It has been proposed that skeletal disorders, such as osteoporosis, may benefit from vitamin K2-based therapies or its regular intake. However, further studies are needed to better clarify the effects of vitamin K2 in bone disorders. To this aim, we developed in vitro a three-dimensional (3D) cell culture system one step closer to the bone microenvironment based on co-culturing osteoblasts and osteoclasts precursors obtained from bone specimens and peripheral blood of the same osteoporotic patient, respectively. Such a 3-D co-culture system was more informative than the traditional 2-D cell cultures when responsiveness to vitamin K2 was analyzed, paving the way for data interpretation on single patients. Following this approach, the anabolic effects of vitamin K2 on the osteoblast counterpart were found to be correlated with bone turnover markers measured in osteoporotic patients’ sera. Overall, our data suggest that co-cultured osteoblasts and osteoclast precursors from the same osteoporotic patient may be suitable to generate an in vitro 3-D experimental model that potentially reflects the individual’s bone metabolism and may be useful to predict personal responsiveness to nutraceutical or drug molecules designed to positively affect bone health.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The body is in a straight line to maintain the movement. (5) For diagonal support of the kneeling position, take the kneeling position, first support the body with both hands and knees, straighten both upper limbs, bend both hips and knees by 90°, then straighten the left upper limb forward, extend the right lower limb backward, form a straight line with the trunk, and only support the body with the right hand and left knee [ 13 ], alternating on both sides. Each action is repeated 10 times, each action lasts for 5~10 s, and the action interval is 5~10 s. The five training movements were performed in two groups for a total of about 40 minutes (about 3 minutes for double leg bridging, about 5 minutes for bilateral alternation of single leg bridging, 3 minutes for treadmill in lying position, about 3 minutes for plate support, and about 5 minutes for bilateral alternation of diagonal support in the kneeling position).…”

Section: Experimental Analysismentioning

confidence: 99%

Effect of Core Muscle Strength Training Combined with Taijiquan on Bone Mineral Density Measured by Quantitative CT Scanning in the Elderly

Zhong

2022

Scanning

View full text Add to dashboard Cite

Learn about the benefits of muscle strength training combined with tai chi for adult skeletal muscle in multiple CT scanning. The study included 182 people over the age of 60 with no long-term history of physical activity and exercise. They were divided into the Taijiquan group (52 people), student muscle strength group (45 people), student muscle group combined with Taijiquan group (45 people), and control group (40 people). The board of directors did not attend. The other three groups received tai chi (more than 4 times a week), muscle strength training, and muscle training combined with tai chi for 6 months. Lumbar spine (L1-4) BMD and Berg scores were approximately the same as those measured in adults before exercise and at 3 and 6 months after exercise. The results showed that there were significant differences in the scores of lumbar spine BMD and Berg Balance Scale between the Taijiquan group and students before and after exercise combined with muscle strength training ( P < 0.05 or <0.01). The difference was statistically significant ( P < 0.05 ). The scores of lumbar BMD and Berg Balance Scale in the core muscle strength training combined with Taijiquan group after 6 months of exercise were higher than those after 3 months of exercise ( P < 0.05 ), and the CT value of lumbar vertebral bone calcium was significantly positively correlated with BMD (Pearson correlation coefficients of L5 vertebral body were r = 0.704 , 0.683, 0.728, 0.673, and 0.686, P < 0.01 ). Single or combined training of core muscle strength or Taijiquan can improve lumbar bone mineral density and balance function in the elderly.

show abstract

“…Также в отношении сохранения МПКТ поясничного отдела позвоночника у женщин в постменопаузе эффективность показала и тройная комбинация витамина K 2 в дозе 100 мкг в день, кальция в дозе 800 мг в день и витамина D в дозе 10 мкг (400 МЕ) в день [43]. Однако в недавнем рандомизированном контролируемом исследовании популяции постменопаузальных китайских женщин средних лет и в пожилом возрасте дополнительное добавление к витамину K 2 в дозе 90 мкг в день препаратов кальция (500 мг в день) и витамина D (в дозе 400 МЕ НАУЧНЫЙ ОБЗОР в день) не показало улучшения эффекта в сравнении с монотерапией витамином K 2 [44]. Единичные исследования применения витамина K 2 с антирезорбтивными препаратами, в частности с бисфосфонатами, также продемонстрировали неоднозначные результаты: так, комбинация с алендронатом была ассоциирована с повышением МПКТ в бедренной кости у женщин с постменопаузальным остеопорозом [45], в то время как комбинированная терапия с ризедронатом не показала эффективности по сравнению с монотерапией ризедронатом [46].…”

Section: влияние витамина K 2 на костную тканьunclassified

Bone metabolism in diabetes mellitus: focus on vitamin K2

Radugin

Karonova

2022

Osteopor Bone Dis

View full text Add to dashboard Cite

Diabetes mellitus (DM) type 2 is reported to be among the most common diseases both worldwide and in Russian Federation, whereby chronic implications that develop under hyperglycemia pose a serious socioeconomic problem. Besides of classic microvascular complications like diabetic retinopathy, nephropathy and polyneuropathy it’s recently worthy of note the presence of high fracture risk in DM type 2 even in normal bone mass density, known as “diaporosis” or “diabetoporosis” considered as another DM complication. It is well known that osteoporosis is reported to be widespread disease as same as DM type 2 and likewise is a widely abundant in older age that makes their combination is really possible in a single patient. Taking into account high social value and disability due to osteoporotic fractures and chronic DM type 2 complications it becomes necessary to continue physiologic and biochemical basis investigations of bone formation and remodeling and pathogenesis of osteoporosis development in the context of chronic hyperglycemia. One of the fairly new factors which the experts believe it is link between impaired glucose metabolism and bone remodeling is osteocalcin which concentration is dependent on vitamin K2 maintenance considered as a potential agent in osteoporotic fractures prevention. In this review current information on vitamin K2 influence on bone status and possibility of using this nutrient in clinical practice in the focus on patients with DM will be covered.

show abstract

Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study

Cited by 19 publications

References 42 publications

Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2

Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2

Effect of Core Muscle Strength Training Combined with Taijiquan on Bone Mineral Density Measured by Quantitative CT Scanning in the Elderly

Bone metabolism in diabetes mellitus: focus on vitamin K2

Contact Info

Product

Resources

About