Effect of low‐dose N‐acetyl‐cysteine infusion on tourniquet‐induced ischaemia‐reperfusion injury in arthroscopic knee surgery

Abstract

Low-dose n-acetyl cysteine infusion attenuates lipid peroxidation and ischaemia-reperfusion injury in arthroscopic knee surgery requiring tourniquet application.

Effect of Preconditioned Hyperbaric Oxygen and Ozone on Ischemia-Reperfusion Induced Tourniquet in Skeletal Bone of Rats

“…Many studies were performed to investigate tourniquet-induced ischemia-reperfusion injury on skeletal muscle in both animal models and human models [29,30]. But there are limited studies investigating tourniquet-induced IR injury on bone tissue.…”

Carbosulfan-induced oxidative damage following subchronic exposure and the protective effects of N-acetylcysteine in rats

“…N-acetylcysteine has antioxidant role and it reacts most strongly with hydroxyl radical and with hypochloric acid, but reacts poorly with the hydrogen peroxide and superoxide radicals (Arakawa and Ito 2007). It may also exert an indirect antioxidant effect by facilitating GSH biosynthesis and supplying GSH for GSH-Px-catalyzed reactions (Saricaoglu et al 2005). GSH-Px converts hydrogen peroxide to water (Halliwell 2006).…”

Permanent and transient effects of locally delivered n-acetyl cysteine in a guinea pig model of cochlear implantation

“…The drug is currently used clinically, having been shown to reduce the incidence and severity of contrast-induced neuropathy (Sanaei-Ardekani et al, 2005;Schultz et al, 2006). It has also been used in clinical trials aimed at reducing reperfusion injury following knee surgery (Ege et al, 2006;Saricaoglu et al, 2005).…”