Effect of low-dose lanthanum carbonate on calcium and phosphorus metabolism in Asian Patients with end-stage renal disease, maintenance hemodialysis and hyperphosphatemia

Abstract

Objective: This study aimed to examine whether a 12-week small-dose lanthanum carbonate (LaCO3; 500 mg/d) treatment could improve calcium and phosphorus metabolism and parathyroid function in Asian patients with end-stage renal disease (ESRD) under hemodialysis.
 Methods: This was a prospective observational study of patients treated at our Hospital between 10/2014 and 02/2015. The patients were given 500 mg/d of LaCO3 with lunch for 12 weeks.
 Results: Baseline and after 12-week treatment serum phosphorus levels were 2.49±0.51 mmol/L and 1.65±0.34 mmol/L (P<0.001). The baseline and after 12-week treatment calcium×phosphorus product were 69.40±17.34 mg2/dL2 and 44.27±9.67 mg2/dL2 (P<0.001). There was no significant difference in serum calcium and iPTH levels from baseline to after 12 weeks treatment (both P>0.05). Fourteen (25.9%) patients developed gastrointestinal adverse reactions to LaCO3and 10 patients improved after treatment.
 Conclusion: Far below the 1.5-3.0g/d required by the drug instructions, LaCO3 500 mg/d for 12 weeks can still reduce serum phosphorus level and calcium × phosphorus product, without serum calcium and iPTH levels increase.
 Keywords: Low dose; Lanthanum carbonate; Hyperphosphatemia; End-stage renal disease; Hemodialysis; Asian.

Toxic Effects of Rare Earth Elements on Human Health: A Review

“…After long-term exposure to REEs, REE deposition can be detected in bone tissue, which reduces bone density and interferes with bone metabolism, leading to osteoporosis and bone and joint injury [51][52][53]. This is because the influence of REEs can directly replace Ca 2+ calcium phosphorus metabolism or can indirectly regulate the osteoclast combination of Ca 2+ receptor-induced osteoporosis [54,87]. Large deposits of REEs were also detected in patients with liver injuries in a mining area, and there was a U-shaped relationship between serum REE levels and oral cancer risk, indicating that large doses of REE exposure can cause gastrointestinal injury [88,89].…”

Editorial

“…It includes: cardiovascular disease [26][27][28][29][30][31] ; cancer [32][33][34][35][36][37][38] . The rest include: kidney disease [39][40] ; foreign bodies in the esophagus and liver cirrhosis [41][42] ; and GI endoscopy [43][44] . References 1.…”