Effect of low dosage of carbenoxolone sodium on gastric ulcer healing and acid secretion.

A Comparison of Carbenoxolone Sodium and Deglycyrrhizinated Liquorice in the Treatment of Gastric Ulcer in the Ambulant Patient

“…Wilcoxon's test was then applied and again the difference was insignificant. Finally, using the scale suggested by Cocking and MacCaig (1969), the degree of healing was assessed (1 a healed, 2 = healing, 3 = no change, 4 = larger). No adjustment for sex or age was required.…”

“…Finally. using the scale suggested by Cocking and MacCaig (1969), the degree of healing was assessed (1 =healed. 2 = healing.…”

Medical Management of Peptic Ulcer With reference to anti-ulcer agents in other gastro-intestinal diseases

“…A smaller dose (50 mg 3 times daily) produces fewer side-effects, but a less marked effect on the healing rate (Cocking and MacCaig, 1969 ;Doll et al, 1968a, b) . It is therefore recommended that 300 mg per day be given for the first week and subsequently 150 mg per day (Watkinson, 1968).…”

“…One problem relates to the extent to which they can occur as isolated phenomena. The most common complications are :-Hypertension , Fluid Retention and Hypokalaernia These effects have, to varying degrees, been found in up to 30 %of patients given 100 mg carbenoxolone sodium 3 times daily (Doll et al, 1962(Doll et al, , 1965(Doll et al, , 1968aHorwich and Galloway, 1965;Turpie and Thomson, 1965;Bank et al, 1967a;Montgomery , 1967;Rosch and Ottenjann, 1971) to 16 % of patients given 50 mg 3 times daily (Cocking and MacCaig, 1969). The rise in blood pressure may be substantial and may be in excess of 50 mm Hg systolic (Doll et al, 1968a, b).…”

Effects of carbenoxolone sodium on stress‐induced gastric damage in rats

“…It has been shown to reduce gastric acid output in response to histamine in man (Bank, Marks, Palmer, Groll & Van Eldik, 1967;Cocking & MacCaig, 1969) and to reduce the total acidity of gastric juice collected from anaesthetized pylorus ligated rats (Henman, 1970). In addition to an effect on gastric acidity, Henman (1970) has demonstrated dose-related antipeptic activity with this compound both in vivo and in vitro and suggests that its therapeutic activity may be related in part to its effect on gastric acidity and peptic activity.…”