Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats

Kostogrys, Renata B.; Franczyk-Żarów, Magdalena; Maślak, Edyta; Topolska, Kinga

doi:10.1016/j.etap.2015.01.008

Cited by 18 publications

(12 citation statements)

References 38 publications

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“…These results were consistent with a previous study using C57BL/6 mice (2); thus, the validity of the LC-HP diet used in the current study was verified. As shown in previous studies (4,5), we also confirmed an increase in kidney weight in the current study (Table 3). However, the current study did not reveal the effects of the LC-HP diet on kidney function.…”

Section: Discussionsupporting

confidence: 93%

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Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice

Shima

Yoshikawa

Onishi

2022

J Nutr Sci Vitaminol

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Low-carbohydrate and high-protein (LC-HP) diets are acceptable for improving physiological and metabolic parameters. However, the effects of LC-HP diets on the brain are unclear, which depend on glycometabolism for neuronal activity. Since astrocyte-neuron lactate shuttle (ANLS) is an essential pathway for maintaining brain functions, we investigated the changes in hippocampal memory function. In addition, the alteration of lactate transporter constituting ANLS and ANLS-related neurotrophic factors by feeding LC-HP diets was evaluated in healthy mice. C57BL/6 mice were divided into two groups: a group feeding LC-HP diet (24.6% carbohydrate, 57.6% protein, and 17.8% fat as percentages of calories) and a group feeding control diet (58.6% carbohydrate, 24.2% protein, and 17.2% fat as percentages of calories). Here, we found that 4 wk of LC-HP diet feeding suppressed memory function in mice evaluated by Y-maze. Hippocampal mRNA levels of lactate transporters, such as Mct1, Mct4, and Mct2, were unchanged with feeding LC-HP diets; however, LC-HP diets significantly decreased Dcx and Igf-1 receptor mRNA levels in the hippocampus. Bdnf and its related signaling in mice hippocampus exhibited no change by LC-HP diets. Although there was non-influence in the lactate-transport system, LC-HP diets would suppress hippocampal working memory with dysregulation of neuroplasticity. The current data propose the importance of food choices for maintaining hippocampal health.

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Section: Discussionsupporting

confidence: 93%

“…On the other hand, opposing faces of LC-HP diets have been reported. For example, previous studies showed that LC-HP diets induce atherosclerosis and dysfunction in the kidney and vessels (4)(5)(6). Therefore, LC-HP diets should be taken fully to understand the dietary effects.…”

mentioning

confidence: 99%

Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice

Shima

Yoshikawa

Onishi

2022

J Nutr Sci Vitaminol

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“…This might be because the changes in our diets were relatively modest compared to the diets used in these studies, furthermore, our WT and Tg animals were young (they were only 8 months old when sacrificed) and if we would have continued the study to a more advanced age, there likely would have been more significant differences between body weights of the four dietary groups. Finally, we did not observe any change in kidney weights in the HP group indicating that the higher level of protein in the diet was not causing kidney damage (Cuenca-Sanchez and others 2015; Kostogrys and others 2015). …”

Section: Discussionmentioning

confidence: 64%

Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice

Kadish

Kumar

Beitnere

et al. 2016

Experimental Gerontology

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Clinical and epidemiological evidence suggests that lifestyle factors, including nutrition, may influence the chances of developing of Alzheimer’s disease (AD), and also likely affect the aging process. Whereas it is clear that high-fat diets are increasing both body weight and the risk of developing Alzheimer’s disease, to date, there have been very few studies comparing diets high with different sources of calories (i.e., high fat versus high protein versus high carbohydrates) to determine whether dietary composition has importance beyond the known effect of high caloric intake to increase body weight, AD pathology and cognitive deficits. In the current study we examined the effects that different diets high in carbohydrate, protein or fat content, but similar in caloric value, have on the development of cognitive impairment and brain pathology in wild-type and Tg AD model mice. The results demonstrate that long term feeding with balanced diets similar in caloric content but with significant changes in the source of calories, all negatively influence cognition compared to the control diet, and that this effect is more pronounced in Tg animals with AD pathology.

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“…The NP diet was the AIN 93M standard diet for adult rodents [183], and the other diets were achieved by interchanging casein and carbohydrate sources, as detailed in Table 3.1. A level of 50% protein was chosen for the HP diet to determine effects of an extreme protein diet, but one that has been promoted for weight loss [113,[184][185][186]. Rats were given free access to water and diet for the duration of the study.…”

Section: Animals and Dietsmentioning

confidence: 99%

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Islam

Ravandi

Aukema

2018

The Journal of Nutritional Biochemistry

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High protein (HP) diets are often used as a means to reduce obesity, but their long-term effects remain unclear. In vitro studies suggest the involvement of a subset of oxylipins in the tissue response to HP diets. To examine the role of these bioactive lipids in vivo, normal adult male Sprague Dawley rats were provided isocaloric diets with LP (low protein, 8% protein by weight), NP (normal protein, 14%) or HP (50%) diets for 2 weeks, and targeted lipidomic analysis of oxylipins in kidney (cortex and medulla), liver and serum was performed by HPLC-MS/MS. The main group of oxylipins affected by the HP diet was the oxylipins derived from linoleic acid (LA), many of which were elevated in kidney (particularly the medulla) and liver, but reduced in serum of rats provided the HP compared to NP or LP diets. A smaller proportion of other n-6 fatty acid derived oxylipins were lower in kidney and higher in liver, and none were affected in serum, by HP feeding. Few n-3 oxylipins were affected by protein level. In liver only, the oxylipin product to substrate ratios of the soluble epoxide hydrolase enzyme were higher in LP fed rats. Differences between cortex and medulla oxylipins suggest relatively higher cortex activity of 5- and 8-lipoxygenase and cytochrome P450 hydroxylase, and higher medulla cyclooxygenase and 12- and 15-lipoxygenase activity. Further studies are needed to elucidate the physiological effects of the changes in these novel oxylipins in response to short-term dietary HP.

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Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats

Cited by 18 publications

References 38 publications

Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice

Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice

Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

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