Effect of low calcium and low phosphorus diets on the intestinal absorption of water in intact and parathyroidectomized pigs

Abstract

Young pigs, each surgically prepared beforehand with a Thiry-Vella loop of jejunum, were used to study the effect of feeding low calcium and low phosphorus diets on the intestinal absorption of water. Feeding a low phosphorus diet caused a highly significant stimulation in the absorption of water in parathyroid gland-intact and parathyroidectomized pigs; low calcium diets were without effect.

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

“…Mice are widely used in research because a wide variety of genetic tools are available in this species permitting sophisticated mechanistic studies in vivo . However, while surgical parathyroidectomy (PTX) can be used in rats 2345, and larger mammals 678, it is technically very challenging in mice because of the small size of the glands and their variable anatomic distribution 9. Therefore, thyro-parathyroidectomy (TPTX) is typically performed in mice, in which the thyroid and parathyroid glands are removed together 10.…”

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

“…Mice are widely used in research because a wide variety of genetic tools are available in this species permitting sophisticated mechanistic studies in vivo. However, while surgical parathyroidectomy (PTX) can be used in rats 2,3,4,5 , and larger mammals 6,7,8 , it is technically very challenging in mice because of the small size of the glands and their variable anatomic distribution 9 . Therefore, thyro-parathyroidectomy (TPTX) is typically performed in mice, in which the thyroid and parathyroid glands are removed together 10 .…”