Effect of low and high frequency thalamic stimulation on sleep in patients with Parkinson's disease and essential tremor

Arnulf, Isabelle; Bejjani, Boulos‐Paul; Garma, L; Bonnet, Anne‐Marie; Damier, Philippe; Pidoux, B.; Dormont, Didier; Cornu, Philippe; Derenne, Jean‐Philippe; Agid, Yves

doi:10.1046/j.1365-2869.2000.00171.x

Cited by 34 publications

(19 citation statements)

References 29 publications

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“…The time spent in the various sleep stages was in accordance with previous findings [5], indicating a generally reduced amount of sleep in PD patients as a global sign of sleep disturbance. The K-complex is a spontaneous event generated in cortical networks [3].…”

Section: Discussionsupporting

confidence: 91%

“…However, in two of those studies no exact numbers are given [9,23] and only two of those studies [14,17] presented results of healthy subjects as a control group. In the study by Emser et al [14], sleep spindle rates were 3.0 ± 1.4/min in PD patients and 5.8 ± 1.2/min in healthy controls and were therefore rather high as compared with other studies [5,19] and with our results. None of those patients and subjects was under medical treatment either before or during the study.…”

Section: Discussionsupporting

confidence: 71%

“…Comella et al [9] and Roth et al [30] described a smaller quantity of spindle activity in PD patients with previous thalamotomy than in patients who had not undergone that operation. Arnulf and co-workers [5], however, could not find any change of sleep spindle rate after stimulation of the ventral intermediate nucleus of the thalamus, and pallido-thalamic tractotomy attenuated spindle rate activity only to varying degrees [30]. These studies provide evidence for the involvement of the dopaminergic system in triggering sleep spindles and of the human thalamus in the generation of sleep spindles.…”

Section: Discussionmentioning

confidence: 74%

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Sleep microstructure and neurodegeneration as measured by [123I]?-CIT SPECT in treated patients with Parkinson?s disease

et al. 2004

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 74%

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Sleep microstructure and neurodegeneration as measured by [123I]?-CIT SPECT in treated patients with Parkinson?s disease

et al. 2004

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“…Recently, several dopaminergic agents have been reported to improve sleep in PD (table 1) [50,53,54,55,56,57,58,59]. A study involving 6 patients revealed that insomniac PD patients have an increased total sleep time after subthalamic nucleus stimulation [60]. A follow-up of 30 patients showed that bilateral high frequency subthalamic stimulation improved insomnia symptoms [61].…”

Section: Sleep Disordersmentioning

confidence: 99%

Sleep-Wake Disturbances in Parkinson’s Disease: Current Evidence regarding Diagnostic and Therapeutic Decisions

Bruin

Bittencourt²,

Tufik³

2012

Eur Neurol

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Sleep disorders have been frequently reported in patients with Parkinson’s disease (PD). However, there is insufficient evidence to guide precise recommendations on some diagnostic and treatment strategies. Here, we review clinical studies dealing with sleep abnormalities in PD and present clinical recommendations. Previous studies describing insomnia, excessive daytime sleepiness, narcolepsy-like episodes, circadian changes, sleep-disordered breathing, rapid eye movement sleep behavior disorder, vivid dreams and restless legs syndrome are evaluated. Longitudinal studies associating sleep disorders with PD onset or clinical deterioration are rare: only one longitudinal study associated daytime sleepiness with PD onset. Evidence suggests that clinical investigations must include direct questioning about depressive symptoms, nocturnal cramps, pain, nocturia and nighttime off periods. A patient interview must be conducted regarding sleep symptoms, including nightmares, abnormal behavior during sleep, snoring, restless legs syndrome and daytime sleepiness. Initial evidence indicates that light therapy improves motor function and depression. Advice on sleep hygiene, the treatment of concomitant depression and the careful use of dopaminergic drugs and hypnosedative agents should be considered. To date, very few controlled studies are available to make a recommendation for the management of sleep-wake disturbances in PD.

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“…Sleep disorders have been reported in PD patients. Polysomnographic studies have demonstrated that increased muscle activity impedes the progression of sleep into deep slow-wave sleep and provokes frequent nocturnal arousal [36, 37]. Some reports show reductions in rapid eye movement (REM) sleep in PD patients [34, 38].…”

Section: Introductionmentioning

confidence: 99%

Circadian Determinations of Cortisol, Prolactin and Melatonin in Chronic Methyl-Phenyl-Tetrahydropyridine-Treated Monkeys

Barcia

Mora-Bautista²,

Sánchez-Bahillo³

et al. 2003

Neuroendocrinology

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The aim of this study was to investigate whether prolactin, melatonin and cortisol are altered in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys and if so, whether MPTP may alter the availability of these hormones in chronic experimental parkinsonism. Furthermore, vegetative and sleep disorders have been described in both parkinsonian patients and in MPTP chronic monkeys; these may result indirectly from concomitant hormonal variations. Seven adult male cynomolgus monkeys were used for this experiment. Five were treated with systemic doses of intravenous MPTP but not with L-DOPA or dopaminergic agonists. In their 3rd year of parkinsonism, plasma samples were obtained day and night at 3-hour intervals. Sample collection was repeated three times for each animal. Prolactin, melatonin and cortisol concentrations were determined by enzyme immunoassay and compared with samples taken from the control group. Both MPTP-treated monkeys and the control group displayed a similar secretion pattern for the three hormones, except at several specific times when prolactin and melatonin showed significant differences. No changes were found for cortisol. The results suggest a possible alteration of hormonal metabolism in chronic MPTP parkinsonian monkeys.

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Effect of low and high frequency thalamic stimulation on sleep in patients with Parkinson's disease and essential tremor

Cited by 34 publications

References 29 publications

Sleep microstructure and neurodegeneration as measured by [123I]?-CIT SPECT in treated patients with Parkinson?s disease

Sleep microstructure and neurodegeneration as measured by [123I]?-CIT SPECT in treated patients with Parkinson?s disease

Sleep-Wake Disturbances in Parkinson’s Disease: Current Evidence regarding Diagnostic and Therapeutic Decisions

Circadian Determinations of Cortisol, Prolactin and Melatonin in Chronic Methyl-Phenyl-Tetrahydropyridine-Treated Monkeys

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