Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

Ku, Sae‐Kwang; Seo, Bu-Il; Park, Ji-Ha; Park, Gyu-Yeol; Seo, Young-Bae; Kim, Jae-Soo; Lee, Hyeung-Sik; Roh, Seong‐Soo

doi:10.3748/wjg.15.4799

Cited by 56 publications

(50 citation statements)

References 30 publications

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“…ASMq reduced the indicators of oxidative damage, increased SOD and GSH-Px levels to values similar to normal, while partially normalizing the increased levels of MDA. Furthermore, ASMq was found to reverse or oppose the negative effects of doxorubicin + 5-FU on liver function and liver and heart morphology, which was consistent with previous studies (20,21,(58)(59)(60). In the present study, significant differences were detected in the heart homogenate levels of MDA, GSH-Px and SOD between normal groups and doxorubicin + 5-FU treatment groups.…”

Section: Discussionsupporting

confidence: 81%

“…SOD is able to specifically eliminate free oxygen radicals by transforming surplus oxygen free radicals into hydrogen peroxide, which is transformed by catalase and GSH-Px into water, thus reducing free radical-mediated cell damage (54). Furthermore, GSH-Px is an important antioxidase (19)(20)(21), and may cause lipid peroxide to change into a alcohol type fatty acid, to complement SOD.…”

Section: Discussionmentioning

confidence: 99%

“…Previous pharmacological and clinical studies have demonstrated that ASMq exhibits antioxidant effects, reducing oxidative damage by free radicals (17), anti-DNA oxidative damage, and inhibiting radiation-induced damage in mice (18)(19)(20)(21). In addition, ASMq has been shown to modulate cellular and humoral immunity in a combined stress mouse model, protecting mitochondria and DNA against damage induced by OH in a cell-free system (17,22).…”

Section: Introductionmentioning

confidence: 99%

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Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

Aikemu

Amat

Yusup

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Abnormal Savda Munziq (ASMq), an Uighur medicine formula commonly used in the treatment of cancer, has been speculated to possess antioxidative and antiproliferative effects, and to regulate immune activity. The present study was designed to systematically elucidate the toxicity-reducing activity of ASMq in mice undergoing combination chemotherapy with doxorubicin and 5-fluorouracil (5-FU). The mice were divided into normal (saline, 10 ml/kg) and doxorubicin + 5-FU groups (doxorubicin, 2.5 mg/kg; 5-FU, 10 mg/kg on alternate days). In addition, three groups received different doses of ASMq (2, 4 and 8 g/kg), in addition to doxorubicin (2.5 mg/kg) and 5-FU (10 mg/kg) treatment on alternate days. The histology of the heart and liver, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, malondialdehyde (MDA) concentrations in heart homogenate, and various biochemical parameters of the liver were evaluated. Compared with the normal control group, ASMq dose-dependently improved a number of variables, including body weight, liver index, transaminase and total protein, and partially normalized liver and cardiac pathology. ASMq restored activities of defense antioxidant enzymes SOD and GSH-Px towards normal levels, and decreased MDA concentration in dose-dependent manner. These results demonstrated that ASMq provides significant protection against doxorubicin + 5-FU combination induced hepatotoxicity and cardiotoxicity. Further studies are required to determine the effects of ASMq against doxorubicin + 5-FU-induced toxicity during chemotherapy in vivo.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

Aikemu

Amat

Yusup

et al. 2016

Experimental and Therapeutic Medicine

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show abstract

“…To further detail changes, the total thickness of the fundic mucosa, from the luminal mucosal surface to the muscularis mucosa on the periulcerative regions of the cross‐trimmed histological specimens, was measured using an automated computer‐based image analyzer under microscopy (Model Eclipse 80i, Nikon, Tokyo, Japan) as described by Ku et al. (2009). In addition, lesion invasive percentages in the fundus (%) were also calculated as follows in Equation (1) according to the method of Ku et al.…”

Section: Methodsmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

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“…Previously, Flos Lonicerae extract, which contains CGA as a major component, increased the activities of endogenous antioxidants including GSH, superoxide dismutase and catalase, and ultimately reduced esophageal damage induced by RE (Ku et al, 2009). CGA, a phenolic compound with antiinflammatory and antioxidant properties, inhibited lipopolysaccharide-induced inflammatory cytokines release in RAW264.7 cells (Shan et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats

Kang¹,

Lee²

2014

Biomol Ther

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. www.biomolther.orgEsophageal reflux of gastric contents causes esophageal mucosal damage and inflammation. Recent studies show that oxygenderived free radicals mediate mucosal damage in reflux esophagitis (RE). Chlorogenic acid (CGA), an ester of caffeic acid and quinic acid, is one of the most abundant polyphenols in the human diet and possesses anti-inflammatory, antibacterial and antioxidant activities. In this context, we investigated the effects of CGA against experimental RE in rats. RE was produced by ligating the transitional region between the forestomach and the glandular portion and covering the duodenum near the pylorus ring with a small piece of catheter. CGA (10, 30 and 100 mg/kg) and omeprazole (positive control, 10 mg/kg) were administered orally 48 h after the RE operation for 12 days. CGA reduced the severity of esophageal lesions, and this beneficial effect was confirmed by histopathological observations. CGA reduced esophageal lipid peroxidation and increased the reduced glutathione/oxidized glutathione ratio. CGA attenuated increases in the serum level of tumor necrosis factor-α, and expressions of inducible nitric oxide synthase and cyclooxygenase-2 protein. CGA alleviates RE-induced mucosal injury, and this protection is associated with reduced oxidative stress and the anti-inflammatory properties of CGA.

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Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

Cited by 56 publications

References 30 publications

Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats

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