Effect of longevity genetic variants on the molecular aging rate

Gurinovich, Anastasia; Song, Ze–Zhou; Zhang, William; Federico, Anthony; Monti, Stefano; Andersen, Stacy L.; Jennings, Lori L.; Glass, David J.; Barzilai, Nir; Millman, Sofiya; Perls, Thomas T.; Sebastiani, Paola

doi:10.1007/s11357-021-00376-4

Cited by 14 publications

(18 citation statements)

References 54 publications

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“…217 proteins were associated (20 negatively associated, 197 positively associated) with age ( p < 3.83 × 10 –5 ) in the basic model adjusted for sex, and further refinement by BMI and serum creatinine resulted in 210 (22 negative, 188 positive) age-associated proteins. Growth differentiation factor 15 (GDF15) had the strongest positive association with age, which is supported by several other studies. , Another 10 proteins (metalloproteases, etc.) comprised the most significantly associated proteins.…”

Section: Agingsupporting

confidence: 69%

“…171 The protein signature results from a cohort of 224 participants was replicated in a subsequent analysis of 1000 Ashkenazi Jewish participants associated with APOE genotypes and confirmed a strong overexpression of BIRC2 and a reduced expression of APOB in carriers of the APOE2 allele. 171 The analysis also discovered and replicated associations between longevity variants and slower changes in protein biomarkers of aging, including a novel protein signature of a variant of the CDKN2A/CDKN2B gene in chromosome 9, suggesting genetic regulation of GDF15. However, many humans that grow old will not reach centenarian status, and the natural aging process is related to a decline in overall health in most cases.…”

Section: ■ Agingmentioning

confidence: 78%

“…comprised the most significantly associated proteins. In a recent proteomic analysis using the SomaLogic 4K panel (4387 unique proteins) coupled to genetic variants of the New England Centenarian Study (median age = 104 years), protein signatures associated with rare variants in chromosomes 9 and 13 suggest potentially interesting biomarkers of longevity that are genetically regulated . The protein signature results from a cohort of 224 participants was replicated in a subsequent analysis of 1000 Ashkenazi Jewish participants associated with APOE genotypes and confirmed a strong overexpression of BIRC2 and a reduced expression of APOB in carriers of the APOE2 allele .…”

Section: Agingmentioning

confidence: 82%

“…Growth differentiation factor 15 (GDF15) had the strongest positive association with age, which is supported by several other studies. 171,172 Another 10 proteins (metalloproteases, etc.) comprised the most significantly associated proteins.…”

Section: ■ Agingmentioning

confidence: 99%

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Advances and Utility of the Human Plasma Proteome

et al. 2021

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The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological advances and the urgent need to understand the effects of COVID-19, the proteomic analysis of blood-derived serum and plasma has become even more important for studying human biology and pathophysiology. Here we provide views and perspectives about technological developments and possible clinical applications that use mass-spectrometry(MS)- or affinity-based methods. We discuss examples where plasma proteomics contributed valuable insights into SARS-CoV-2 infections, aging, and hemostasis and the opportunities offered by combining proteomics with genetic data. As a contribution to the Human Proteome Organization (HUPO) Human Plasma Proteome Project (HPPP), we present the Human Plasma PeptideAtlas build 2021-07 that comprises 4395 canonical and 1482 additional nonredundant human proteins detected in 240 MS-based experiments. In addition, we report the new Human Extracellular Vesicle PeptideAtlas 2021-06, which comprises five studies and 2757 canonical proteins detected in extracellular vesicles circulating in blood, of which 74% (2047) are in common with the plasma PeptideAtlas. Our overview summarizes the recent advances, impactful applications, and ongoing challenges for translating plasma proteomics into utility for precision medicine.

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Section: Agingsupporting

confidence: 69%

Section: ■ Agingmentioning

confidence: 78%

Section: Agingmentioning

confidence: 82%

Section: ■ Agingmentioning

confidence: 99%

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Advances and Utility of the Human Plasma Proteome

et al. 2021

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“…Centenarians are being studied as a model for healthy ageing [ 1 – 4 ] aiding researchers in understanding the determinants of both exceptional health span and life span. Centenarians do not only exhibit intriguing exceptional survivorship.…”

Section: Introductionmentioning

confidence: 99%

Dietary patterns and survival to 100 + years: an empty systematic review of cohort and case–control studies

2022

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Background Centenarians are used as a model of healthy ageing and longevity. Diet is a factor known to affect mortality in middle aged adults and elderly. However, it is unknown whether diet has an impact on survival to 100 + years. The aims of this systematic review were to summarize the evidence on (i) the association between dietary patterns in late adult life and survival to 100 + years and (ii) the common characteristics across dietary patterns that are shown to be positively associated with survival to 100 + years. Methods We performed a systematic literature search in MEDLINE and EMBASE, and a hand search at four longevity projects homepages up to 4 June 2021. We searched for cohort and case–control studies investigating the association between dietary patterns and all-cause mortality among individuals aged ≥ 65 years at enrolment regardless of their health status and residence. Studies were excluded if follow-up was performed too soon to allow the population or a subgroup of it to have become 100 + years of age. Results Of 3,685 identified records 108 reports were retrieved and full text screened. No studies met our inclusion criteria, thus the review process resulted in no eligible studies found. Hence, no risk of bias assessment and no synthesis of data was performed. Conclusions No studies have investigated dietary patterns in late adult life in relation to survival to 100 + years of age. We have observed that as of June 2021 published cohort studies exist investigating all-cause mortality risk from different dietary patterns among the oldest old, but follow-up has been performed before the cohort could have reached 100 years of age. However, cohorts do exist where data on dietary habits in adult life has been collected decades ago and where follow-up in 2022 will allow the participants to have become 100 + years old. Registration The review protocol is published at University of Southern Denmark’s Research Portal (Poulsen et al. Dietary Patterns and Survival to 100 + Years: Protocol for a Systematic Review of cohort and case–control studies University of Southern Denmark's Research Portal: University of Southern Denmark, 2021) available at https://portal.findresearcher.sdu.dk/en/publications/kostm%C3%B8nstre-og-overlevelse-til-100-%C3%A5r-protokol-for-en-systematisk. We have specified aim (i) of our research question in this report compared to the protocol, by adding “late” to “adult life”.

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