Effect of Long Term Mobile Phone Exposure on Oxidative-Antioxidative Processes and Nitric Oxide in Rats

Daşdağ, Süleyman; Bilgin, Hakkı Murat; Akdağ, Mehmet; Çelik, Hakim; Aksen, Feyzan

doi:10.1080/13102818.2008.10817595

Cited by 52 publications

(30 citation statements)

References 32 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that patients diagnosed with degenerative liver diseases have higher level of lipoperoxide in their liver tissues and several forms of liver diseases have been shown to be associated with oxidative tissue injury (Suematsu et al 1981). Dasdag et al (2008) reported increased levels of MDA and of the total oxidant status in liver tissue of the Wistar albino rats exposed to 900 MHz RF radiation. However, they found no significant endpoints in terms of catalase, myeloperoxidase, total antioxidant capacity levels.…”

Section: Discussionmentioning

confidence: 99%

900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissue

Eşmekaya¹,

Özer²,

Seyhan³

2011

gpb

View full text Add to dashboard Cite

Abstract. Oxidative stress may affect many cellular and physiological processes including gene expression, cell growth, and cell death. In the recent study, we aimed to investigate whether 900 MHz pulse-modulated radiofrequency (RF) fields induce oxidative damage on lung, heart and liver tissues. We assessed oxidative damage by investigating lipid peroxidation (malondialdehyde, MDA), nitric oxide (NO x ) and glutathione (GSH) levels which are the indicators of tissue toxicity. A total of 30 male Wistar albino rats were used in this study. Rats were divided randomly into three groups; control group (n = 10), sham group (device off, n = 10) and 900 MHz pulsed-modulated RF radiation group (n = 10). The RF rats were exposed to 900 MHz pulsed modulated RF radiation at a specific absorption rate (SAR) level of 1.20 W/kg 20 min/day for three weeks. MDA and NO x levels were increased significantly in liver, lung, testis and heart tissues of the exposed group compared to sham and control groups (p < 0.05). Conversely GSH levels were significantly lower in exposed rat tissues (p < 0.05). No significantly difference was observed between sham and control groups. Results of our study showed that pulse-modulated RF radiation causes oxidative injury in liver, lung, testis and heart tissues mediated by lipid peroxidation, increased level of NO x and suppression of antioxidant defense mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissue

Eşmekaya¹,

Özer²,

Seyhan³

2011

gpb

View full text Add to dashboard Cite

show abstract

“…Oxidative stress may accelerate the peroxidation reactions of lipids in liver (11). It has been reported that patients diagnosed with degenerative liver diseases have higher level of lipoperoxide in their liver tissues and several forms of liver diseases have been shown to be associated with oxidative tissue injury (19). Dasdag et al (19) reported increased levels of MDA and of the total oxidant status in liver tissue of the Wistar albino rats exposed to 900 MHz RF-EMR.…”

Section: Discussionmentioning

confidence: 99%

1800 MHz radio-frequency electromagnetic radiation induces oxidative stress in rat liver, kidney and brain tissues

Berköz¹,

Arslan²,

Yıldırım³

et al. 2018

Eastern J Med

View full text Add to dashboard Cite

“…One of the reasonable pathways of RF/MW intracellular action is based on the generation of reactive oxygen species (ROS). Increased levels of ROS, antioxidants, and cellular damage were found in different types of investigations including cell cultures, laboratory animals, and even in the humans after RF/MW exposure (67)(68)(69)(70)(71)(72)(73)(74) On the other hand, the blood levels of MDA, CAT, vitamins A, D3, and E increased and GSH decreased. A study conducted by Moustafa et al (49) examined the effect of acute exposure to 900 MHz radiofrequency fi eld on 12 male volunteers.…”

Section: Discussionmentioning

confidence: 99%

“…The proposed model theoretically proved that pulsed EM fi elds could be twice as effective biologically as the continuous ones (32). Furthermore there have been a number of papers connecting exposure of RF/MW radiation with excessive formation of free radicals (67)(68)(69)(70)(71)(72)(73)(74). Action of free radicals is additionally enhanced in the presence of oxygen which further causes the formation of new radicals.…”

Section: Biological Mechanisms Of Rf/mw Actionmentioning

confidence: 99%

Biological indicators in response to radiofrequency/microwave exposure

Marjanović

Pavičić

Trošić

2012

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Over the years, due to rapid technological progress, radiation from man-made sources exceeded that of natural origin. There is a general concern regarding a growing number of appliances that use radiofrequency/ microwave (RF/MW) radiation with particular emphasis on mobile communication systems. Since nonthermal biological effects and mechanisms of RF/MW radiation are still uncertain, laboratory studies on animal models, tissues, cells, and cell free system are of extraordinary importance in bioelectromagnetic research. We believe that such investigations play a supporting role in public risk assessment. Cellular systems with the potential for a clear response to RF/MW exposures should be used in those studies. It is known that organism is a complex electrochemical system where processes of oxidation and reduction regularly occur. One of the plausible mechanisms is connected with generation of reactive oxygen species (ROS). Depending on concentration, ROS can have both benefi cial and deleterious effects. Positive effects are connected with cell signalling, defence against infectious agents, and proliferative cell ability. On the other hand, excessive production, which overloads antioxidant defence mechanism, leads to cellular damage with serious potential for disease development. ROS concentration increase within the cell caused by RF/MW radiation seems to be a biologically relevant hypothesis to give clear insight into the RF/MW action at non-thermal level of radiation. In order to better understand the exact mechanism of action and its consequences, further research is needed in the fi eld. We would like to present current knowledge on possible biological mechanisms of RF/MW actions.

show abstract

Effect of Long Term Mobile Phone Exposure on Oxidative-Antioxidative Processes and Nitric Oxide in Rats

Cited by 52 publications

References 32 publications

900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissue

900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissue

1800 MHz radio-frequency electromagnetic radiation induces oxidative stress in rat liver, kidney and brain tissues

Biological indicators in response to radiofrequency/microwave exposure

Contact Info

Product

Resources

About