Effect of Long-Term Green Tea Polyphenol Supplementation on Bone Architecture, Turnover, and Mechanical Properties in Middle-Aged Ovariectomized Rats

Shen, Chwan Li; Smith, Brenda J.; Li, Jiliang; Cao, Jay; Song, Xiao; Newhardt, Maria F.; Corry, Kylie A.; Tomison, Michael D.; Tang, Lili; Wang, Jia Sheng; Chyu, M.-C.

doi:10.1007/s00223-018-0489-y

Cited by 18 publications

(17 citation statements)

References 60 publications

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“…This result supported our previous study that found post GTME could enhance RUNX2 and OSX in alveolar bone of Wistar Rats during OTM due to presence of EGCG in the extract [33]. The antioxidant ability of EGCG that consisted in GTME may increase the bone turnover [8,9,13].…”

Section: Administration Of Egcg During Otm Can Inhibit Excessive Exprsupporting

confidence: 90%

“…OTM was installed by using NiTi close coil spring with 6 mm length (American Orthodontics Corp., Sheboygan, WI, USA), placed between the incisor and maxillary molars to move the molar mesially with 10g force and measured by the using tension gauge (American Orthodontics Corp., Sheboygan, WI, USA). The fixed orthodontic appliance was fixated by applying 0.07 stainless steel ligature wire (American Orthodontics Corp., Sheboygan, WI, USA) ( Figure 1B) [9].…”

Section: Samplingmentioning

confidence: 99%

“…Based on in vitro and in vivo study, Catechin has strong antioxidants [5]. Green tea has been known to have many benefits for human life, including being an immunomodulator and antifungal, ameliorate bone resorption, and promote bone formation [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

Nugraha

Narmada

Sitasari

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)-Epigallocatechin-3-Gallate (EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration in vivo. Material and Methods: 28 Wistar rats (Rattus Novergicus) was used and divided into 4 groups accordingly: K-without EGCG and OTM; K+ with OTM, without EGCG for 14 days; T1with OTM for 14 days and EGCG for 7 days; treatment group 2 (T2) with OTM and EGCG for 14 days. OTM animal model was achieved through the installation of the OTM device by means of NiTi close coil spring with 10g force placed between the first incisor and first maxillary molars. The samples were terminated on Day 14. The pre-maxillary was isolated for the immunohistochemical examination. Analysis of Variance (ANOVA) then continued with Tukey Honest Significant Difference (HSD) (p<0.05) was performed to analyze the data. Results: The highest HMGB1 and HSP-70 expression were found in the K+ group pressure side, meanwhile the lowest HMGB1 and HSP-70 expression were found in K-group tension side in the alveolar bone. There was a significant decrease of HMGB1 and HSP-70 expression in T2 compared to T1 and K+ with significant between groups (p<0.05; p=0.0001). Conclusion: The decreased expression of HMGB1 and HSP-70 in alveolar bone of OTM wistar rats due to post administration of GTME that consisted EGCG.

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Section: Administration Of Egcg During Otm Can Inhibit Excessive Exprsupporting

confidence: 90%

Section: Samplingmentioning

confidence: 99%

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High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

Nugraha

Narmada

Sitasari

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…In this study, we found that those individuals with higher baseline urinary levels of polyphenols had larger BCA, CMC, and CTh. However, during the 6-year follow-up, There is ample evidence that lifestyles and nutrition may affect bone quality [6,12,27]. In particular, it has been suggested that polyphenols, active compounds present in many fruits and vegetable may have beneficial effect in chronic disease prevention, and in particular osteoporosis [27].…”

Section: Discussionmentioning

confidence: 99%

“…The biological activity of polyphenols has been attributed to their antioxidant and anti-inflammatory properties [10,11]. Pre-clinical studies suggested that polyphenols suppress bone resorption, either by inhibition of osteoclastogenesis and/or increased apoptosis of osteoclasts [12][13][14]. There is also some evidence that polyphenols may stimulate osteoblast maturation and survival [15].…”

Section: Introductionmentioning

confidence: 99%

Total urinary polyphenols and longitudinal changes of bone properties. The InCHIANTI study

et al. 2020

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The aim of this study was to evaluate the association of levels of urinary total polyphenols considered as a proxy measure of polyphenol intake, with longitudinal changes of bone properties, in the InCHIANTI study. Dietary intake of polyphenols appears to be associated with future accelerated deterioration of bone health. Introduction Polyphenols, micronutrients ingested through plant-based foods, have antioxidant and anti-inflammatory properties and may contribute to osteoporosis prevention. We evaluated associations of high levels of urinary total polyphenols (UTP), a proxy measure of polyphenol intake, with longitudinal changes of bone properties in a representative cohort of free-living participants of the InCHIANTI study. Methods The InCHIANTI study enrolled representative samples from the registry list of two towns in Tuscany, Italy. Baseline data were collected in 1998 and follow-up visits in 2001 and 2004. Of the 1453 participants enrolled, 956 consented to donate a 24-h urine sample used to assess UTP, had dietary assessment, a physical examination, and underwent a quantitative computerized tomography (pQCT) of the tibia. From pQCT images, we estimated markers of bone mass (BM), diaphyseal design (DD), and material quality (MQ). Mixed models were used to study the relationship between baseline tertiles of UTP with changes of the bone characteristics over the follow-up. Results At baseline, higher levels of UTP were positively correlated with markers of BM, DD, and MQ. Compared with lower tertile of UTP, participants in the intermediate and highest tertiles had higher cortical bone area, cortical mineral content, and cortical thickness. However, participants in the intermediate and highest UTP tertiles experienced accelerated deterioration of these same parameters over the follow-up compared with those in the lowest UTP tertile. Conclusions Dietary intake of polyphenols estimated by UTP and dietary questionnaire was associated with long-term accelerated deterioration of bone health. Our study does not support the recommendation of increasing polyphenol intake for osteoporosis prevention.

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Maternal Exposure to Red Rooibos Does Not Alter Bone Development in Male or Female Sprague-Dawley Rat Offspring

Yumol¹,

McAlpine²,

Ward³

2023

Current Developments in Nutrition

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Effect of Long-Term Green Tea Polyphenol Supplementation on Bone Architecture, Turnover, and Mechanical Properties in Middle-Aged Ovariectomized Rats

Cited by 18 publications

References 60 publications

High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

Total urinary polyphenols and longitudinal changes of bone properties. The InCHIANTI study

Maternal Exposure to Red Rooibos Does Not Alter Bone Development in Male or Female Sprague-Dawley Rat Offspring

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