Effect of long-term food restriction  on cardiac mechanics

Klebanov, Simon; Herlihy, Jeremiah T.; Freeman, Gregory L.

doi:10.1152/ajpheart.1997.273.5.h2333

Cited by 23 publications

(22 citation statements)

References 40 publications

(54 reference statements)

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“…Parameters assessed to evaluate systolic function are those most commonly utilized in this preparation (6,21,38,43,46): 1) slope of end-systolic pressure-volume normalized relationship (ESPVNR; mmHg ⅐ ml Ϫ1 ⅐ g Ϫ1 ) [volume was normalized to LVW as suggested by Suga et al (44) and the mean ESPVNR curve was obtained; steeper slope indicates increased myocardial contractility]; 2) maximum rate of ventricular pressure rise (ϩdP/dt; mmHg/s); and 3) maximum developed pressure (DP max; mmHg), corresponding to the difference between peak systolic pressure and diastolic pressure with the LV balloon filled to develop an end-diastolic pressure of 25 mmHg.…”

Section: Systolic Function Indexesmentioning

confidence: 99%

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Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

Fioretto

Querioz

Padovani

et al. 2002

American Journal of Physiology-Heart and Circulatory Physiology

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Section: Systolic Function Indexesmentioning

confidence: 99%

“…Various studies have separately assessed passive properties of cardiac muscle (30) and the LV chamber (2, 3), as well as the active relaxation phase (19,21,39); however, none has evaluated all these indexes in the same animal model as was done in this study.…”

mentioning

confidence: 99%

Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

Fioretto

Querioz

Padovani

et al. 2002

American Journal of Physiology-Heart and Circulatory Physiology

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“…During postnatal development the contractile apparatus matures (12) and this is associated with profound changes in the modulatory effect of b-adrenoreceptor signalling. Novotny et al (13) suggested that the differential maturation of various components of the signal transduction pathway may contribute to complex age-dependent changes in the cardiac responsiveness and sensitivity to b-adrenergic stimulation.It is well established that food restriction of the adult rat modifies b-adrenergic responsiveness of the heart (14,15) , suggesting that these pathways are responsive to nutritional * Corresponding author: Dr Matthew Elmes, fax þ44 115 951 6122, email matthew.elmes@nottingham.ac.uk Abbreviations: AUC, area under the curve; dP/dt max , rate of pressure development; LVDP, left ventricular developed pressure; MLP, maternal low protein. …”

mentioning

confidence: 99%

“…It is well established that food restriction of the adult rat modifies b-adrenergic responsiveness of the heart (14,15) , suggesting that these pathways are responsive to nutritional * Corresponding author: Dr Matthew Elmes, fax þ44 115 951 6122, email matthew.elmes@nottingham.ac.uk Abbreviations: AUC, area under the curve; dP/dt max , rate of pressure development; LVDP, left ventricular developed pressure; MLP, maternal low protein.…”

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confidence: 99%

Sex differences in sensitivity to β-adrenergic agonist isoproterenol in the isolated adult rat heart following prenatal protein restriction

et al. 2008

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Hypertension is a major risk factor for the development of CVD. Epidemiological studies have shown that low birth weight increases the risk of developing hypertension in adulthood. Hypertension increases the risk of suffering IHD and early findings provide evidence that hearts from prenatally protein-restricted, hypertensive, male offspring are more susceptible to cardiac dysfunction following ischaemic events. Hypertension and abnormalities in cardiac function following ischaemia -reperfusion in the human population are treated therapeutically with b-adrenergic antagonists. We hypothesised that increased susceptibility to myocardial ischaemia -reperfusion injury in prenatally programmed offspring may be due to sympathetic hyperactivity. Pregnant Wistar rats were fed control or low-protein (maternal low protein; MLP) diets throughout gestation. At age 6 months, hearts were rapidly excised and retro-perfused using the Langendorff apparatus, to assess isolated cardiac function following stimulation with increasing doses of the non-specific b-agonist isoproterenol. Baseline heart rates were similar in control and MLP-fed offspring. With significant diet £ sex interactions (P, 0·01) maximum heart rate response following isoproterenol infusion was significantly longer in MLP than control. Prenatal diet had no effect on maximal left ventricular developed pressure (LVDP) response, but the LVDP isoproterenol response was significantly longer in duration in MLP-exposed male offspring (diet £ sex P, 0·001). Myocardial mRNA expression of b2-adrenergic receptors was increased in 2-week-old female MLP offspring only (P,0·049). In conclusion, maternal protein restriction programmes cardiac sympathetic activity in a sex-specific manner, and may explain increased susceptibility to ischaemia -reperfusion injury in males subject to fetal undernutrition.Protein restriction: Heart: b-Adrenergic agonists: Fetal programming Hypertension has been identified by the WHO as the second major cause of death in developed countries (1) . In England, 34 % of men and 30 % of women have raised blood pressure and it is estimated that 80 % of these individuals are not receiving treatment. Epidemiological studies have shown a clear relationship between characteristics at birth and the occurrence of CVD in adult life (2 -4) . Size at birth is an early indicator of disease risk. In particular, low birth weight (2) or thinness at birth (3) is associated with the development of hypertension. These observations have led to the hypothesis that adult CVD arises as a result of impaired fetal growth and development in utero, following suboptimal nutrition during the early developmental stages of life (4) . Elevated blood pressure and cardiovascular dysfunction are commonly reported results of intra-uterine exposure to maternal undernutrition in rodents (5) and sheep (6) .A common therapeutic strategy aimed at decreasing high blood pressure and myocardial ischaemia-reperfusion injury includes the use of b-adrenergic antagonists. This is based on the fact t...

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“…This period of time was chosen because Klebanov et al 10 observed similar changes in mechanical function of normotensive rats when undergoing FR for 10 to 13 months or for three weeks. The hypothesis tested was that hypertrophied hearts, which need a higher nutritional supply, would present more changes with FR.…”

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confidence: 99%

Effects of protein-calorie restriction on mechanical function of hypertrophied cardiac muscle

Cicogna¹,

Padovani²,

Georgette³

et al. 1999

Arq. Bras. Cardiol.

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Objective -To assess the effect of food restriction (FR) on hypertrophied cardiac muscle in spontaneously hypertensive rats (SHR). Methods -Isolated papillary muscle preparations of the left ventricle (LV) of 60-day-old SHR and of normo-. PCM can affect a series of organs and tissues. There is evidence in humans and especially in experimental animals that PCM can cause damage to the cardiovascular system. PCM can promote the following alterations: 1) clinical changes that vary from bradycardia to heart failure; 2) functional changes, such as reduction in cardiac output, in ventricular compliance, and in myocardial contractility; 3) biochemical changes, such as the activation of calciumdependent proteinase, reduction of the protein synthesis and of the RNA/DNA ratio, and an increase in DNA; and 4) morphological changes, such as dilation of the cardiac chambers, atrophy and/or degeneration of myocytes, interstitial and mitochondrial edema, and increase in colagen [3][4][5][6] . Hypertrophy of myocardial cells is the most efficient mechanism for cardiac compensation in response to increased workload. Its purpose is to maintain adequate cardiac performance in response to systemic metabolic demands.The spontaneously hypertensive rats (SHR) were developed as a genetic model of hypertension, which in many ways is similar to essential hypertension in man. The animals develop early left ventricular hypertrophy (LV), which is responsible for the maintenance of the normal cardiac function, despite the elevated systemic blood pressure (BP).Information in the literature about the influence of different types of nutritional deficiencies on the functional behavior of the hypertrophied muscle is scarce [7][8][9] . Yokota et al 7 observed that SHR fed a protein-deficient diet showed deterioration of LV function. Tabayashi et al 8 observed that dogs with LV hypertrophy that underwent chronic PCM had normal pump function and a reduced myocardial contractility. Olivetti et al 9 , studying SHR with nutritional anemia, observed LV dilation and dysfunction in those animals.Due to lack of information in the literature about the association between PCM and function of the hyper-

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Effect of long-term food restriction on cardiac mechanics

Cited by 23 publications

References 40 publications

Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

Sex differences in sensitivity to β-adrenergic agonist isoproterenol in the isolated adult rat heart following prenatal protein restriction

Effects of protein-calorie restriction on mechanical function of hypertrophied cardiac muscle

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