Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis

Gao, Ye; Lu, Jiandong; Liu, Xinhong; Liu, Jingqi; Ma, Qirui; Shi, Yajun; Su, Hao

doi:10.3389/fphys.2021.748517

Cited by 8 publications

(7 citation statements)

References 32 publications

(25 reference statements)

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“…As described in the introduction, exercise decreases hepatic fat may be independent of energy consumption partially. Although many investigations have examined the effectiveness of a single exercise modality on hepatic fat reduction, few studies have compared the different combinations of resistance training plus moderate-intensity continuous training or high-intensity interval training ( 28 , 50 , 51 ). In the current physical activity guidelines, individuals with chronic diseases need to perform moderate-intensity aerobic physical activity or vigorous-intensity aerobic physical activity combined with muscle-strengthening activity.…”

Section: Discussionmentioning

confidence: 99%

The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial

Huang

Ruan

Huo³

et al. 2023

Front. Nutr.

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IntroductionMetabolic flexibility (MetF) is the capacity of an organism to oxidate substrate according to substrate availability or demand. The mismatch of substrate availability and oxidation may cause ectopic fat accumulation in the muscle and the liver. The objectives of the study are to examine the effect of 12 weeks of combined exercise on hepatic fat reduction and investigate metabolites related to MetF before and after the high-fat diet between individuals with NAFLD and healthy control with an active lifestyle.MethodsThis study is an open-label, single-center trial randomized controlled clinical study plus a cross-sectional comparison between individuals with NAFLD and healthy control. Individuals with NAFLD were allocated into two groups receiving resistance training (RT) combined with high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT). Anthropometric indicators, clinical blood markers about glucose, lipid metabolism, and hepatic fat content (HFC) were assessed before and after the intervention. The metabolomics was also used to investigate the discrepant metabolites and mechanisms related to MetF.DiscussionMetabolic flexibility reflects the capacity of an organism to switch the oxidation substrates flexibly, which is associated with ectopic fat accumulation. Our study aimed to explore the discrepant metabolites related to MetF before and after a high-fat diet between individuals with NAFLD and healthy control. In addition, the study also examined the effectiveness of RT combined with HIIT or MICT on hepatic fat reduction and quantificationally analyzed the metabolites related to MetF before and after the intervention. Our results provided a perspective on fatty liver-associated metabolic inactivity.Trial registrationClinicalTrials.gov: ChiCTR2200055110; Registered 31 December 2021, http://www.chictr.org.cn/index.aspx.

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Section: Discussionmentioning

confidence: 99%

The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial

Huang

Ruan

Huo³

et al. 2023

Front. Nutr.

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“…Various systematic reviews with meta-analyses have reported pooled analyses for several cardiometabolic outcomes across a broad range of exercise prescriptions. The majority of evidence supports the benefits of exercise on total cholesterol [ 64 , 71 , 74 , 75 , 121 , 124 , 125 ], potentially driven by benefits on LDL-cholesterol [ 54 , 64 , 65 , 75 , 79 , 82 , 121 , 124 , 125 ]. While one meta-analysis demonstrated within-group benefits for exercise on hepatic insulin sensitivity [ 69 ], the efficacy for improving glycaemic control [ 54 , 65 , 73 , 75 , 79 , 80 ] and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) [ 25 , 50 , 54 , 59 , 60 , 66 , 67 , 70 , 76 , 123 ] in people with MAFLD is inconsistent.…”

Section: Section 2: Evidence For the Role Of Exercise In The Manageme...mentioning

confidence: 99%

Exercise in the Management of Metabolic-Associated Fatty Liver Disease (MAFLD) in Adults: A Position Statement from Exercise and Sport Science Australia

Keating,

Sabag,

Hallsworth

et al. 2023

Sports Med

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Metabolic-associated fatty liver disease (MAFLD) is the most prevalent chronic liver disease worldwide, affecting 25% of people globally and up to 80% of people with obesity. MAFLD is characterised by fat accumulation in the liver (hepatic steatosis) with varying degrees of inflammation and fibrosis. MAFLD is strongly linked with cardiometabolic disease and lifestyle-related cancers, in addition to heightened liver-related morbidity and mortality. This position statement examines evidence for exercise in the management of MAFLD and describes the role of the exercise professional in the context of the multi-disciplinary care team. The purpose of these guidelines is to equip the exercise professional with a broad understanding of the pathophysiological underpinnings of MAFLD, how it is diagnosed and managed in clinical practice, and to provide evidence- and consensus-based recommendations for exercise therapy in MAFLD management. The majority of research evidence indicates that 150–240 min per week of at least moderate-intensity aerobic exercise can reduce hepatic steatosis by ~ 2–4% (absolute reduction), but as little as 135 min/week has been shown to be effective. While emerging evidence shows that high-intensity interval training (HIIT) approaches may provide comparable benefit on hepatic steatosis, there does not appear to be an intensity-dependent benefit, as long as the recommended exercise volume is achieved. This dose of exercise is likely to also reduce central adiposity, increase cardiorespiratory fitness and improve cardiometabolic health, irrespective of weight loss. Resistance training should be considered in addition to, and not instead of, aerobic exercise targets. The information in this statement is relevant and appropriate for people living with the condition historically termed non-alcoholic fatty liver disease (NAFLD), regardless of terminology.

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“…It might seem that long-term PA has a distinct and pronounced effect on reducing liver fat content, as measured by MRS or computer tomography scans [ 28 , 123 , 124 ]. Several studies have shown a clear trend towards lower ectopic fat content in the liver after long-term PA, especially in subjects with overweight, obesity, and/or non-alcoholic fatty liver disease [ 125 , 126 ]. It may also seem that plasma free fatty acids, triglycerides, total and low-density cholesterol levels, are lower after long-term PA, probably due to reduced liver fat content, in these individuals [ 125 , 126 ].…”

Section: Effects Of Long-term Pa On Irmentioning

confidence: 99%

“…Several studies have shown a clear trend towards lower ectopic fat content in the liver after long-term PA, especially in subjects with overweight, obesity, and/or non-alcoholic fatty liver disease [ 125 , 126 ]. It may also seem that plasma free fatty acids, triglycerides, total and low-density cholesterol levels, are lower after long-term PA, probably due to reduced liver fat content, in these individuals [ 125 , 126 ]. Furthermore, we have shown that fat content in the liver may be reduced after long-term PA also for normal-weight [ 26 ].…”

Section: Effects Of Long-term Pa On Irmentioning

confidence: 99%

Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance

et al. 2022

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Insulin became available for the treatment of patients with diabetes 100 years ago, and soon thereafter it became evident that the biological response to its actions differed markedly between individuals. This prompted extensive research into insulin action and resistance (IR), resulting in the universally agreed fact that IR is a core finding in patients with type 2 diabetes mellitus (T2DM). T2DM is the most prevalent form of diabetes, reaching epidemic proportions worldwide. Physical activity (PA) has the potential of improving IR and is, therefore, a cornerstone in the prevention and treatment of T2DM. Whereas most research has focused on the acute effects of PA, less is known about the effects of long-term PA on IR. Here, we describe a model of potential mechanisms behind reduced IR after long-term PA to guide further mechanistic investigations and to tailor PA interventions in the therapy of T2DM. The development of such interventions requires knowledge of normal glucose metabolism, and we briefly summarize an integrated physiological perspective on IR. We then describe the effects of long-term PA on signaling molecules involved in cellular responses to insulin, tissue-specific functions, and whole-body IR.

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Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 32 publications

The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial

The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial

Exercise in the Management of Metabolic-Associated Fatty Liver Disease (MAFLD) in Adults: A Position Statement from Exercise and Sport Science Australia

Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance

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