Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol.

Satoh, Hisashi; Kuwaki, Tomoyuki; Shirakawa, Kamon; Kohjimoto, Yoshiro; Ono, Takaharu; Shibayama, Fumio; Nomura, Yasuyuki

doi:10.1254/jjp.44.393

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…Other evidence suggests that radiolabeled benzamides, such as raclopride and sulpiride, may differ from spiperone in the sites that are labeled (Theodorou et al, 1980;Zahniser et al, 1983) and may preferentially bind to a subclass of D2 receptors (Kohler et al, 1979;Memo et al, 1980;Ogren et al, 1986). Rats treated with sulpiride for 4 weeks (Rupniak et al, 1984a) or 12 months (Rupniak et al, 1984b) showed no increase in [3H]spiperone binding, although they did show an increase in [3H-lN-,n-propylnorapomorphine (NPA), a D2 receptor ligand which differs from [3H]spiperone (Battaglia and Titeler, 1982); similar results were found after chronic tiapride (Satoh et al, 1987). The results of the present study, in which raclopride-treated animals showed signs of increased D2 binding with [3H]raclopride, but not [3H]spiperone, suggests the possibility that raclopride is preferentially acting at a subpopulation of D2 receptors, resulting in a selective upregulation.…”

Section: Discussionmentioning

confidence: 69%

Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats

See

Toga

Ellison

1990

J. Neural Transmission

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Rats were administered haloperidol, clozapine, raclopride, or no drug for 28 days or 8 months. Following a 3 week withdrawal period, in vitro autoradiography was utilized to examine receptor binding for dopamine D2 ([3H]spiperone and [3H]raclopride), dopamine D 1 ([3H]SCH23390), GABA(A) ([3H]muscimol), benzodiazepine ([3H]RO15-1788), and muscarinic ACh receptors ([3H]QNB). [3H]spiperone was elevated in striatal subregions only in haloperidol-treated rats, with the largest increases seen in the 8 month duration animals. Striatal [3H]raclopride binding was increased after both short- and long-term treatment in both haloperidol and raclopride, but not clozapine-treated animals. Clozapine-treated rats showed significant increases in [3H]SCH23390 in the nucleus accumbens after 28-day administration; otherwise no changes were seen for this ligand in any other groups. Increases in [3H]muscimol binding in the substantia nigra reticulata were seen in haloperidol-treated rats after 8 month treatment. Binding of [3H]QNB and [3H]RO151788 were not significantly different from control for any of the drug-treated groups. These data suggest that persisting alterations in receptor binding are primarily seen in dopamine D2 and GABA receptors after withdrawal from chronic administration of haloperidol but not the atypical neuroleptics, clozapine and raclopride.

show abstract

Section: Discussionmentioning

confidence: 69%

Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats

See

Toga

Ellison

1990

J. Neural Transmission

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show abstract

“…Hence, it is likely that differences in results between different studies might be due to experimental conditions (e. g., dosing i. p. or oral application, time interval between drug application and measurement, chemicals, etc. ), as stated by Satoh et al [25] themselves. Nevertheless, a measurable acute effect of tiapride on the dopaminergic systems can be assumed when the drug is given in a medium or high dose.…”

Section: Discussionmentioning

confidence: 64%

“…Only acute tiapride treatment leads to a significant reduction of dopamine and DOPAC, while HVA remained unchanged. Satoh et al [25] also found a slight reduction of dopamine in the striatum upon giving a single acute dose of tiapride (100 mg/kg, i. p.) to Wistar rats aged 42±63 days. On the other hand, DOPAC and HVA were increased 2 hours, but not 3 days, after the acute dose of tiapride.…”

Section: Discussionmentioning

confidence: 91%

Early Administration of Tiapride to Young Rats without Long-lasting Changes in the Development of the Dopaminergic System

Bock¹,

Moll²,

Wicker³

et al. 2004

Pharmacopsychiatry

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“…In contrast to the findings for haloperidol (Ziemann et al, 1997), tiapride did not significantly alter baseline CE. The differential effects may be due to dosage or divergent pharmacological profiles of these DA-antagonists (Kohler et al, 1984; Satoh et al, 1987). Other studies found enhanced CE after motor training alone (Abbruzzese et al, 1996; Muellbacher et al, 2001; Koeneke et al, 2006; Cirillo et al, 2010, 2011).…”

Section: Discussionmentioning

confidence: 99%

Opposing effects of dopamine antagonism in a motor sequence taskâ€”tiapride increases cortical excitability and impairs motor learning

Lissek

Vallana

Schlaffke

et al. 2014

Front. Behav. Neurosci.

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The dopaminergic system is involved in learning and participates in the modulation of cortical excitability (CE). CE has been suggested as a marker of learning and use-dependent plasticity. However, results from separate studies on either motor CE or motor learning challenge this notion, suggesting opposing effects of dopaminergic modulation upon these parameters: while agonists decrease and antagonists increase CE, motor learning is enhanced by agonists and disturbed by antagonists. To examine whether this discrepancy persists when complex motor learning and motor CE are measured in the same experimental setup, we investigated the effects of dopaminergic (DA) antagonism upon both parameters and upon task-associated brain activation. Our results demonstrate that DA-antagonism has opposing effects upon motor CE and motor sequence learning. Tiapride did not alter baseline CE, but increased CE post training of a complex motor sequence while simultaneously impairing motor learning. Moreover, tiapride reduced activation in several brain regions associated with motor sequence performance, i.e., dorsolateral PFC (dlPFC), supplementary motor area (SMA), Broca's area, cingulate and caudate body. Blood-oxygenation-level-dependent (BOLD) intensity in anterior cingulate and caudate body, but not CE, correlated with performance across groups. In summary, our results do not support a concept of CE as a general marker of motor learning, since they demonstrate that a straightforward relation of increased CE and higher learning success does not apply to all instances of motor learning. At least for complex motor tasks that recruit a network of brain regions outside motor cortex, CE in primary motor cortex is probably no central determinant for learning success.

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Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol.

Cited by 7 publications

References 24 publications

Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats

Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats

Early Administration of Tiapride to Young Rats without Long-lasting Changes in the Development of the Dopaminergic System

Opposing effects of dopamine antagonism in a motor sequence taskâ€”tiapride increases cortical excitability and impairs motor learning

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