Effect of long-term antibiotic use on weight in adolescents with acne

Contopoulos‐Ioannidis, Despina G.; Ley, Catherine; Wang, Wei; Ma, Ting; C, Olson; Shi, Xiaoli; Luft, Harold S.; Hastie, Trevor; Parsonnet, Julie

doi:10.1093/jac/dkv455

Cited by 5 publications

(4 citation statements)

References 54 publications

(35 reference statements)

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“…Past studies have shown that exposure to antibiotics at early infancy (<6 months of age) were associated with increases in BMI and risk of obesity at 10 to 36 months of age, 14 , 31 but not at later ages. 4 , 32 Our present study supports these observations by showing stronger associations with magnitude of BMI at peak (approximately 8 months of age) than at rebound (approximately 52 months of age) after antibiotic exposure at 0 to 5 months of age. Other studies have documented longer-term effects on overweight and obesity in late childhood after exposure to antibiotics at early infancy.…”

Section: Discussionsupporting

confidence: 86%

“…4,16 Gerber et al4 reported a 2% increase in the growth rate for children who were exposed to antibiotics in the first 2 years, whereas Schwartz et al16 estimated excess weight gains of 0.73 to 1.50 kg from 3 to 18 years of age for children who received antibiotics. The similarity in the magnitude of associations across these different studies adds credibility to our findings.Past studies have shown that exposure to antibiotics at early infancy (<6 months of age) were associated with increases in BMI and risk of obesity at 10 to 36 months of age,14,31 but not at later ages 4,32. Our present study supports these observations by showing stronger associations with magnitude of BMI at peak (approximately 8 months of age) than at rebound (approximately 52…”

supporting

confidence: 87%

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Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones

et al. 2021

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IMPORTANCE Past studies have showed associations between antibiotic exposure and child weight outcomes. Few, however, have documented alterations to body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) trajectory milestone patterns during childhood after early-life antibiotic exposure. OBJECTIVE To examine the association of antibiotic use during the first 48 months of life with BMI trajectory milestones during childhood in a large cohort of children.

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Section: Discussionsupporting

confidence: 86%

supporting

confidence: 87%

Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones

et al. 2021

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“…Differences in populations (including age and geography) and in drugs features (antibiotic classes, dosages, number of courses) may explain this disagreement. The importance of early-life exposure in driving the metabolic effects of antibiotics has been confirmed by data on antibiotic administration during pregnancy135 and adolescence,136 which respectively confirm and disagree with those observed in infant population.…”

Section: Effects Of Antibiotics On Non-communicable Disordersmentioning

confidence: 93%

Antibiotics as deep modulators of gut microbiota: between good and evil

Ianiro

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Gasbarrini

2016

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“… 29 Other work using retrospective cohort data has suggested that long-term antibiotic use in healthy adolescents with acne was not associated with weight gain. 31 …”

Section: Discussionmentioning

confidence: 99%

Prescribing of long-term antibiotics to adolescents in primary care: a retrospective cohort study

et al. 2021

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Background: Antibiotic overuse is linked with increased risk of antimicrobial resistance. Long-term antibiotics are commonly used for treating acne and prophylaxis of urinary tract infection. Their contribution to the overall burden of antibiotic use is relatively unknown. Aim: To describe the volume of commonly prescribed long-term (>= 28 days) antibiotic prescriptions in adolescents and young adults, trends over time and comparisons with acute prescriptions. Design and Setting: Retrospective cohort study using UK electronic primary care records. Methods: Patients born between 1979 and 1996 in the Care and Health Information Analytics database were included. Our main outcome measures were antibiotic prescription rates per 1000 person years, antibiotic prescription days per person year between ages 11-21. Results: 320,722 participants received a total of 710,803 antibiotic prescriptions between the ages of 11-21 from 1998 to 2017. 191,443/710,803 (26.93%) prescriptions were for long-term antibiotics (≥28 days and ≤ 6 months in duration). Long-term antibiotics accounted for more than two-thirds (72.48%) of total antibiotic exposure (days per person year). Total long-term antibiotic prescribing peaked in 2013 at just under 6 days per person year and declined to around 4 in 2017. Conclusions: Amongst adolescents and young adults, exposure to long-term antibiotics (primarily lymecycline used for acne) was much greater than for acute antibiotics and is likely to make an important contribution to antimicrobial resistance. Urgent action is needed to reduce unnecessary exposure to long-term antibiotics in this group. Increasing the use of and adherence to effective, non-antibiotic treatments for acne is key to achieving this.

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Effect of long-term antibiotic use on weight in adolescents with acne

Abstract: Contrary to original expectations, long-term antibiotic use in healthy adolescents with acne was not associated with weight gain. This finding, which was consistent across all analyses, does not support a weight-promoting effect of antibiotics in adolescents.

Cited by 5 publications

References 54 publications

Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones

Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones

Antibiotics as deep modulators of gut microbiota: between good and evil

Prescribing of long-term antibiotics to adolescents in primary care: a retrospective cohort study

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