Effect of Long-Detection Interval vs Standard-Detection Interval for Implantable Cardioverter-Defibrillators on Antitachycardia Pacing and Shock Delivery

Gasparini, Maurizio; Proclemer, Alessandro; Klersy, Catherine; Kloppe, Axel; Lunati, Maurizio; Ferrer, J B Martinez; Hersi, Ahmad; Gułaj, Marcin; Wijfels, Maurits C E F; Santi, Elisabetta; Manotta, Laura; Arenal, Ángel

doi:10.1001/jama.2013.4598

Cited by 369 publications

(293 citation statements)

References 21 publications

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“…All the patients were implanted with either a dual-chamber ICD or a CRT-D programmed to deliver ATP before charging. After a mean 1.4-year follow-up, the prolonged detection group (Arm C) was associated with a reduction in treated VT/VF leading to a 76% reduction in the primary endpoint of the first inappropriate therapy (P The Avoid Delivering Therapies for Non-Sustained Arrhythmias in ICD Patients III (ADVANCE III) trial reported that a long detection was associated with a highly significant reduction of overall therapies (appropriate and inappropriate ATP and/ or shocks), inappropriate shocks, and all-cause hospitalizations [97]. Importantly, like PRE-PARE, RELEVANT, and MADIT-RIT, the extended detection duration used in the ADVANCE III trial (30 of 40) did not negatively impact the rate of syncopal events.…”

Section: Duration Criteria For the Detection Of Ventricular Arrhythmiamentioning

confidence: 99%

“…The annual rate of inappropriate shocks has fallen dramatically from 37%-50% for SVT alone in early studies to 1%-5% for all causes in modern clinical trials [97,118,[126][127][128]. This decrease is likely due to differences in both clinical populations and the programming of multiple ICD parameters, including longer detection time and higher rate cutoffs.…”

Section: What Evidence Supports a Benefit?mentioning

confidence: 99%

“…When modern algorithms are programmed to recommended parameters, clinically significant underdetection is rare. Large clinical trials on multiple shock-reduction strategies (including SVT-VT discrimination) report no or minimal and statistically insignificant increases in syncope [95,97,126,133]. Most reports do not include the causes of syncope and thus do not permit identification of whether discrimination algorithms contributed to any of the syncopal episodes by prolonging detection.…”

Section: What Are the Risks?mentioning

confidence: 99%

See 2 more Smart Citations

2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing

et al. 2016

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Section: Duration Criteria For the Detection Of Ventricular Arrhythmiamentioning

confidence: 99%

Section: What Evidence Supports a Benefit?mentioning

confidence: 99%

Section: What Are the Risks?mentioning

confidence: 99%

See 1 more Smart Citation

2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing

et al. 2016

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“…Conversely, one study has demonstrated that appropriate or inappropriate shocks are one of the risk factors for prognosis 7 , and subanalysis of data from MADIT-and SCD-HeFT showed a two-fold increased risk of death in patients who experienced inappropriate ICD shocks 8,9 . New strategies, changing the detection time and zone for ventricular arrhythmia, have been proposed to reduce inappropriate shocks [10][11][12][13] .…”

Section: Originalmentioning

confidence: 99%

Effect of Cardiac Rehabilitation in Preventing Implantable Cardioverter Defibrillator Therapy in Patients with Reduced Left Ventricular Ejection Fraction

Ogawa

Kawamura

Koba

et al. 2017

Showa Univ J Med Sci

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: In patients with implantable cardioverter de brillators ICD or cardiac resynchronization therapy defibrillators CRT-D , appropriate and inappropriate shocks lead to a higher risk of mortality. Cardiac rehabilitation CR is an established therapy for patients with ischemic heart disease and / or congestive heart failure. However, it is unclear whether CR could reduce the need for device therapies. The purpose of the present study was to investigate whether CR reduces device therapies and mortality in patients with severe cardiac dysfunction and ICD or CRT-D. Of the 390 patients who were implanted with an ICD or CRT-D between 1998 and 2015, 222 178 men, 44 women with a low ejection fraction EF ; 45 were investigated in this present study. The study cohort was divided into two groups, the CR group n 70 and the non-CR group n 152 , and baseline clinical characteristics of the two groups were compared. Furthermore, the number of all device therapies, appropriate therapies, inappropriate therapies, and mortality for 1 year after ICD or CRT-D implantation were compared. There were no signi cant differences in baseline characteristics between the CR and non-CR groups e.g. age 68.5 vs 66.2 years P 0.16 ; EF 27.9 vs 29.7 P 0.14 . Kaplan-Meier analysis revealed that all device therapy events and inappropriate therapy events were lower in the CR than non-CR group P 0.01 and P 0.03, respectively . Appropriate therapy events and mortality did not differ signi cantly between the two groups 5.7 vs 13.1 P 0.09 and 11.4 vs 17.0 P 0.28 , respectively . CR may have bene cial effects in preventing therapy events, especially inappropriate therapy, in patients with an ICD or CRT-D.

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“…While several studies have compared outcomes between single-chamber and dual-chamber ICDs, these investigations had major limitations, yielded conflicting results, and predated the evidence on optimal programming of ICDs. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Today's health care providers and patients, therefore, often struggle in making the critical decision of what device type to choose, and professional societies and policymakers are incapable of developing evidence-based recommendations and coverage decisions. 8,33 These issues are further compounded by the advent of subcutaneous ICDs, whose outcomes, especially in the elderly, are uncertain.…”

Section: Professional Societies/ Researchersmentioning

confidence: 99%

Future Research Prioritization: Implantable Cardioverter-Defibrillator Therapy in Older Patients

et al. 2015

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BACKGROUND: Although the implantable cardioverterdefibrillator (ICD) is highly effective therapy for preventing sudden cardiac death, there is considerable uncertainty about its benefits and harms in older patients, especially in the presence of factors, other than old age, that increase the risk of death. OBJECTIVE: To develop a prioritized research agenda for the Patient-Centered Outcomes Research Institute as informed by a diverse group of stakeholders on the use and outcomes of the ICD in older patients. DESIGN: The existing literature was reviewed to identify evidence gaps, which were then refined by engaged stakeholders. Using a forced-ranking prioritization method, the stakeholders ranked evidence gaps by importance. For the highest-ranked evidence gaps, relevant recent studies were identified using PubMed, and relevant ongoing trials were identified using ClinicalTrials.gov. PARTICIPANTS: Eighteen stakeholders, including clinical experts and researchers in the prevention of sudden cardiac death and ICD therapy, representatives from federal and non-governmental funding agencies, representatives from relevant professional societies, health care decision-makers and policymakers, and representatives from related consumer and patient advocacy groups KEY RESULTS: The top 12 evidence gaps prioritized by stakeholders were related to the safety and effectiveness of ICDs in older patient subgroups not well represented in clinical trials, predictors of SCD, the impact of the ICD on quality of life, the use of shared decision-making, disparities in ICD use, risk stratification strategies, patient preferences, and distribution of modes of death in older patients. CONCLUSIONS: In this paper, we identify evidence gaps of high priority for current and future investigations of ICD therapy. Addressing these gaps will likely resolve many of the uncertainties surrounding the use and outcomes of the ICD in older patients seen in clinical practice.KEY WORDS: stakeholder engagement; cardiovascular disease; decision making.

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Effect of Long-Detection Interval vs Standard-Detection Interval for Implantable Cardioverter-Defibrillators on Antitachycardia Pacing and Shock Delivery

Cited by 369 publications

References 21 publications

2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing

2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing

Effect of Cardiac Rehabilitation in Preventing Implantable Cardioverter Defibrillator Therapy in Patients with Reduced Left Ventricular Ejection Fraction

Future Research Prioritization: Implantable Cardioverter-Defibrillator Therapy in Older Patients

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