Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum

Cheah, A.M.

doi:10.1016/0005-2736(81)90025-0

Cited by 96 publications

(32 citation statements)

References 27 publications

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“…First, Cheah (1981) reported that free 18 : 2 fatty acid can stimulate the release of calcium and inhibit calcium uptake from the SR membrane. It is possible that 18 : 2 from the SR membrane released by endogenous phospholipase A2 induced the ryanodine receptor (RyR1) to release calcium.…”

Section: Possible Mechanismsmentioning

confidence: 99%

Feeding wet distillers grains plus solubles contributes to sarcoplasmic reticulum membrane instability

et al. 2018

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Abstract. Feeding wet distillers grains plus solubles (WDGS) increases polyunsaturated fatty acid (PUFA) levels in beef. It was hypothesised that WDGS in feedlot diets increases PUFA concentration in the sarcoplasmic reticulum (SR) membrane, thereby altering membrane integrity, resulting in more rapid intracellular calcium leakage and improved tenderness. The objective of this study was to evaluate this hypothesis. Ninety-six crossbred steers were fed either a corn-based diet with 0% WDGS or 50% WDGS. Fifteen strip loins per treatment were collected, fabricated into steaks, aged and placed under retail display conditions. Steaks were used to measure tenderness, proteolysis, free calcium concentrations, lipid oxidation, sarcomere length and SR membrane fatty acid, phospholipid lipid, neutral lipid and total lipid profiles. Compared with steaks from steers fed 0% WDGS, steaks from steers fed 50% WDGS were more tender (P < 0.05) and had greater (P < 0.05) free calcium concentrations early post-mortem. Feeding 50% WDGS also tended to increase (P < 0.10) total PUFA concentrations, decrease (P < 0.10) total phospholipid concentration and increase (P < 0.10) total neutral lipid concentration for SR membrane. Steaks from steers fed 0% WDGS had greater (P < 0.05) lipid oxidation (TBARS values) than steaks from steers fed 50% WDGS after extended aging. Although differences in tenderness between the two treatments were detected, there were no corresponding differences (P > 0.10) in sarcomere length or proteolysis. This study showed that feeding WDGS may increase tenderness, possibly by increasing free calcium in muscle early post-mortem. However, the true mechanism that contributes to these differences is still unclear.

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Section: Possible Mechanismsmentioning

confidence: 99%

Feeding wet distillers grains plus solubles contributes to sarcoplasmic reticulum membrane instability

et al. 2018

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“…The activation of phospholipase C in non-muscle cells is coupled to receptors by G protein(s), and results in an increase in InsP3 that releases Ca2+ from the endoplasmic reticulum (Cockcroft & Gomperts, 1985; for review, see Baker, 1986;Berridge, 1986;Stryer & Bourne, 1986 (Nakamura & Ui, 1985;Nishizuka, 1986;Burch, Luini & Axelrod, 1986;Okano, Yamada, Yano & Nozawa, 1987) could also act as second messengers to release Ca2+ (Cheah, 1981;Wolf, Turk, Sherman & McDaniel , 1986;Brass & Laposata, 1987 Fig. 8).…”

Section: Inhibition Of Gtpys-induced Contraction By Neomycinmentioning

confidence: 99%

“…Our findings do not distinguish between two different stores or a single store that is desensitized to InsP3. The question whether the InsP3-independent component is mediated by another messenger, such as diacylglycerol or phosphatidic acid (Brass & Laposata, 1987) or arachidonic acid (Cheah, 1981;Wolf et al 1986), is currently being investigated. The ability of InsP3 to elicit a response during the maintained phase of GTPyS-induced contraction (Fig.…”

Section: Inhibition Of Gtpys-induced Contraction By Neomycinmentioning

confidence: 99%

Guanine nucleotide‐ and inositol 1,4,5‐trisphosphate‐induced calcium release in rabbit main pulmonary artery.

Kobayashi

Somlyo

1988

The Journal of Physiology

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1. The effects of activation of guanine nucleotide‐binding protein (G protein) by guanine nucleotides or sodium fluoride on the release of intracellular Ca2+ and on tension development were determined in chemically skinned strips of rabbit main pulmonary arteries (MPA). Ca2+ movements were monitored with Fura‐2, as the change in free Ca2+ concentration in the bath medium surrounding the skinned MPA. 2. Sodium fluoride or non‐hydrolysable analogues of GTP, guanosine 5'‐[gamma‐thio]triphosphate (GTP gamma S) and guanosine 5'‐[beta,gamma‐imido]triphosphate (GMP‐PNP), induced sustained and dose‐dependent contraction of skinned MPA. GTP (100 microM) induced transient contraction of skinned MPA. GTP gamma S did not contract intact MPA. We also confirmed that inositol 1,4,5‐trisphosphate (InsP3) released sufficient Ca2+ to induce contraction of skinned, but not intact, MPA. 3. Guanosine 5'‐[beta‐thio]diphosphate (GDP beta S), a non‐hydrolysable analogue of GDP that competitively inhibits the binding of guanine nucleotides to G proteins, inhibited the contractions induced by GTP gamma S. Neomycin (1 mM) inhibited the GTP gamma S‐induced contractions, but also, to a lesser extent, contractions induced by caffeine. 4. Depletion of Ca2+ from the sarcoplasmic reticulum (SR) or treatment with Triton X‐100 inhibited the GTP gamma S‐induced contractions. The effects of Ca2+ depletion was reversible, while that of Triton X‐100 was irreversible. GTP gamma S (up to 100 microM) had no apparent effect on the pCa‐tension curve of freeze‐glycerinated MPA. 5. GTP gamma S‐ or InsP3‐induced contractions occurred in the presence of 20 mM‐procaine, while this agent completely blocked the contraction induced by caffeine. 6. Both GTP gamma S and InsP3 induced an increase in the Fura‐2 fluorescence signal of the bath medium surrounding the skinned MPA, indicating that GTP gamma S releases intracellular Ca2+. The release of Ca2+ induced by GTP gamma S was inhibited by GDP beta S. 7. During the initial phasic contraction induced by GTP gamma S, added InsP3 had little or no additive effect, in contrast to its additive effect during the latter sustained contraction induced by GTP gamma S.(ABSTRACT TRUNCATED AT 400 WORDS)

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“…In skinned vascular smooth muscle Saida & van Breemen (1987) reported that GTP enhances the InsP3-induced Ca2 + release from sarcoplasmic reticulum, and they suggested that guanine nucleotide-binding proteins are involved in the mechanism of Ca2+ -release. Also arachidonic acid would induce Ca2 + release in skeletal muscle (Cheah, 1981) and in permeabilized pancreatic islet cells (Wolf et al, 1986). A similar action of arachidonic acid has been described in rat liver microsomes (Chan & Turk, 1987).…”

Section: Introductionmentioning

confidence: 99%

Properties of intracellular calcium stores in pregnant rat myometrium

Kanmura

Missiaen

Casteels

1988

British J Pharmacology

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Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum

Cited by 96 publications

References 27 publications

Feeding wet distillers grains plus solubles contributes to sarcoplasmic reticulum membrane instability

Feeding wet distillers grains plus solubles contributes to sarcoplasmic reticulum membrane instability

Guanine nucleotide‐ and inositol 1,4,5‐trisphosphate‐induced calcium release in rabbit main pulmonary artery.

Properties of intracellular calcium stores in pregnant rat myometrium

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