Effect of Long-Acting Selenium Preparation on Health and Productivity of Sheep

Błażejak-Grabowska, Justyna; Milewski, S.; Ząbek, Katarzyna; Sobiech, Przemysław; Wójcik, Roman; Żarczyńska, Katarzyna; Miciński, Jan

doi:10.3390/ani12020140

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…A higher percentage of lymphocytes and monocytes may lead to increased WBC counts in lambs supplemented with inorganic selenium. Similar results were reported by [ 65 ] in ewes, but without a significant increase. A significant increase in leukocyte count compared to the control group was observed when goats were orally administered a high dose of more than 2 mg Se/kg DM [ 63 ].…”

Section: Discussionsupporting

confidence: 92%

The Effect of Maternal Dietary Selenium Supplementation on Blood Antioxidant and Metabolic Status of Ewes and Their Lambs

et al. 2022

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This study investigated the effect of dietary selenium supplementation (organic and inorganic) of late-gestation ewes on blood selenium concentrations and metabolic and antioxidant status indicators in ewes and their lambs. In addition, the efficacy of selenium transfer from ewes to lambs during the suckling period was determined. The study was conducted on 30 Merinolandschaf ewes and their lambs and lasted four months. The feed mixture of the control group (group I) contained no added selenium, while the feed mixture of group II was enriched with 0.3 mg/kg of organic selenium sources and the third group with 0.3 mg/kg of inorganic selenium sources. In ewes and their lambs, selenium supplementation significantly (p < 0.01; p < 0.05) increased selenium concentration, glutathione peroxidase, and superoxide dismutase activity and decreased malondialdehyde concentration compared to the control group. Selenium supplementation had a positive effect on metabolism and hematological indicators in lambs. A positive correlation was found between antioxidant indicators in the whole blood of ewes and lambs. The good transfer of selenium from ewes to lambs was complemented by higher correlation coefficients when the feed mixture was supplemented with organic compared to inorganic selenium.

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Section: Discussionsupporting

confidence: 92%

The Effect of Maternal Dietary Selenium Supplementation on Blood Antioxidant and Metabolic Status of Ewes and Their Lambs

et al. 2022

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“…Generally, Se is present in a variety of geological locations in the world [20] . Studies indicate that Se functions as an antioxidant [21] immune protect [22] health and reproductive functions [20] in the body. However, animals need a small amount of Se, but larger amounts are harmful [23] .…”

Section: Introductionmentioning

confidence: 99%

The role of selenium in reproduction of sheep

Al-Ameri

2024

J. Entomol. Zool. Stud.

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This review explores enhancing the reproductive performance and semen quality of sheep for optimal production and profitability. One element that has caught the attention of many researchers is selenium (Se), which plays a crucial biological role in improving reproductive efficiency, boosting antioxidant activity, enhancing semen characteristics, and supporting the immune system in both humans and animals. Se contains enzymes, such as glutathione peroxidase, which help to scavenge free radicals within cells and promote overall health. By incorporating Se into sheep management practices, farmers can potentially maximize their production and profitability while ensuring the health of their flocks. It's important to make sure that sheep have enough Se in their diet or by injection to prevent damage from free radicals and maintain their reproductive health. Supporting the antioxidant protection system is vital for this mineral, which helps counteract the harmful effects of these unstable molecules on cells. Ensuring that sheep have access to enough Se helps to maintain optimal semen quality and reproductive performance. It is noticeable that Se can synergize with vitamins and minerals to give good results in enhancing reproductive performance and semen quality. This review encompasses the studies that have been carried out to evaluate the beneficial impact of Se on sheep reproduction.

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“…Simultaneously, Se is involved in regulating the expression of immune genes in bovine support cells, improving sheep humoral and cellular immunity. Moreover, Se can also improve mice immune responses to vaccines [ 29 , 30 , 31 ]. Only a few studies on canine models have demonstrated the regulation of Se on immune functions.…”

Section: Introductionmentioning

confidence: 99%

Effects of Casein Phosphopeptide-Selenium Complex on the Immune Functions in Beagle Dogs

Wang¹,

Xu²,

Cao

et al. 2022

Animals

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The health of pets is becoming a growing concern for the pet industry and its owners. Immunity is one of the foundational supports for health, thus developing a functional bioactive substance that can boost pets’ immunity is essential. Many studies have shown that casein phosphopeptide (CPP) and selenium (Se) can individually regulate immunity in many species, but there has been no reported research on the immunomodulatory function of casein phosphopeptide–selenium complex (CPP-Se). The objective of this study was to investigate the function of CPP-Se on immunomodulation in dogs. Twenty Beagle dogs were equally divided into two groups and fed either a control snack or a test snack supplemented with 0.03% CPP-Se for 30 days. Anticoagulated blood, serum and peripheral blood lymphocytes (PBL) were collected from dogs at 0 d, 10 d, 20 d and 30 d to detect the change in the number of immune cells and the expression of cytokine-related mRNAs and proteins. PBL isolated from blood were exposed to CPP-Se in vitro to measure the proliferative responses and cytokine-related mRNAs expression. During the time the test snack was fed, the number of lymphocytes increased significantly, whereas neutrophils and monocytes remained unaltered. The expression of interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), CD4 molecule (CD4) and CD8α molecule (CD8α) was up-regulated, while interleukin-1β (IL-1β) was down-regulated, and interleukin-10 (IL-10) declined initially and subsequently increased. ELISA detection revealed a significant increment in serum IL-4, IL-6, Immunoglobulin M (IgM) and IFN-γ, except for IgG. Furthermore, CPP-Se treatment increased the proliferation and the expression of cytokine-related mRNAs in PBL cultured in vitro. This is the first study to demonstrate that CPP-Se can improve immunity in the dog.

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Effect of Long-Acting Selenium Preparation on Health and Productivity of Sheep

Cited by 4 publications

References 33 publications

The Effect of Maternal Dietary Selenium Supplementation on Blood Antioxidant and Metabolic Status of Ewes and Their Lambs

The Effect of Maternal Dietary Selenium Supplementation on Blood Antioxidant and Metabolic Status of Ewes and Their Lambs

The role of selenium in reproduction of sheep

Effects of Casein Phosphopeptide-Selenium Complex on the Immune Functions in Beagle Dogs

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