“Effect of local application of simvastatin in bone regeneration of peri-apical defects-a clinico-radiographic study

Gupta, Shikha; Verma, Parul; Tikku, Aseem Prakash; Chandra, Anil; Yadav, Rakesh Kumar; Bharti, Ramesh; Bains, Rhythm

doi:10.1016/j.jobcr.2020.08.014

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…[32][33][34] The factors mentioned above which indicate the similarity of larger animals such as sheep and humans aided in selecting the dosage of simvastatin which is 10mg and it was similar to the previously done studies on humans. 13,19,28 The results of the present study are in line with those of Mukozaw et al 35 they demonstrated bone healing of critical-sized bone defects in rabbits by statins in different time intervals, using 2.5 mg/ml simvastatin, and the animals were divided into four groups and the groups were sacrificed at periods, 1, 2, 4, 8, and 12 weeks postoperatively. The histologic assessment reveal that more new formation bone in defects filled with simvastatin groups increased significantly at 2, 4, 8, and 12 weeks postoperatively in comparison with the control group.…”

Section: Discussionsupporting

confidence: 90%

“…In addition, it is bioresorbable and conforms easily to the shape of bone defects. 13,19,28 We selected 10 mg as a safe dose to insert in each critical-sized defect with a carrier gelfoam surrounding it. The powder cannot be directly inserted as it will cause severe inflammation in the surrounding soft tissues.…”

Section: Discussionmentioning

confidence: 99%

“…We never got any adverse reaction to the drug in this way. 13,19,28 To our knowledge, no previous studies in a similar manner were done in the sheep model using the local application of Simvastatin in bone defects. In this study, sheep are used as an experimental animal model.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Local Simvastatin on the Healing of Surgically Created Critical-Sized Bone Defects: An experimental Study on sheep.

Abdulsamad,

Omar

2024

EDJ

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Background and objective: the role of simvastatin in lowering serum cholesterol levels is well described. However, recent findings suggest they have a role in bone formation as well. The study aims to determine the effect of local simvastatin application on bone defect healing and compare the amount of new bone produced by a simvastatin-treated defect with that produced by a bone graft (biphasic calcium phosphate) and non-treated defects (left empty) histologically. Methods: Forty-five critical-size defects were created (8mm in diameter and depth) in the iliac bone of 6 sheep. For the first three sheep (5 defects/ilium), the five defects on the right ilium were left empty as a Control group, while the five defects on the left ilium were filled with biphasic calcium phosphate as Test 1 group. For the other three sheep, 5 defects were created on the right ilium, the defects were filled with 10mg crushed simvastatin tablet with gelfoam (as a carrier) as Test 2 group. The animals were sacrificed over periods of 1, 2, and 3 months. Histopathological studies were done for all the samples. SPSS version 28 was used to analyze the results. The numerical variables were checked for normality using Smirnov – Kolmogorov test, then analyzed using ANOVA and unpaired t-test (p–values ≤ 0.05 were considered statistically significant). Results: All 6 adult male sheep passed the scheduled periods uneventfully. During the wound healing period, there was no complication such as infection, excessive hematoma, or wound dehiscence. All 45 standardized iliac bone defects were included in the final analysis (n= 45). The histologic results showed that Test 2 group (defect filled with simvastatin) in the 1st, 2nd, and 3rd months had significantly higher bone formation at the surface and depth of the defects than Test 1 and Control group with P values (<0.0001) at all period intervals. Conclusion: Simvastatin enhances bone formation and accelerates the healing process of the bony defect. Keywords: Bone formation, Bone graft, Bone healing, Simvastatin, Statin.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Effect of Local Simvastatin on the Healing of Surgically Created Critical-Sized Bone Defects: An experimental Study on sheep.

Abdulsamad,

Omar

2024

EDJ

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“…Materials like hydroxyapatite grafts, autologous platelet‐rich fibrin grafts, simvastatin, and collagen are a few examples that have proven to produce better clinical and radiographic healing (Gupta et al., 2020; Sanchez‐Torres et al., 2014; Taschieri et al., 2007). The present study utilized the concept of GTR with bone graft and the two membranes (hAM‐ Experimental; PRF membrane‐Control) to aid in regenerative healing after periapical surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Search for newer and better biological alternatives to these three elements is an area of active research in surgical endodontics. Recently researched tissue engineering materials like platelet‐rich fibrin (PRF), platelet‐rich plasma (PRP), collagen, bone grafts, and simvastatin give promising results in regenerative surgical endodontics (Del Fabbro et al., 2012; Gupta et al., 2020; Liu et al., 2021). One such biologically/naturally derived tissue is the Human amniotic membrane (hAM) which has been utilized in the medical field since 1900 when Dr. Nicholas Sabella first reported a clinical case of burns managed by hAM.…”

Section: Introductionmentioning

confidence: 99%

Effect of amniotic membrane and platelet‐rich fibrin membrane on bone healing post endodontic surgery: An ultrasonographic, randomized controlled study

Johri

Verma

Tikku

et al. 2022

J Tissue Eng Regen Med

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The use of membrane barriers and bone grafting materials in endodontic surgery promotes healing by regeneration rather than repair by scar tissue. Due to its valuable regenerative and therapeutic properties, the human amniotic membrane can support ideal periapical rehabilitation and promote better healing after surgery. The current trial aimed to evaluate the amniotic membrane's healing potential and compare it with platelet‐rich fibrin using color doppler sonography. The current study is a randomized, double‐blinded, parallel‐group, single‐center study. Thirty‐four systematically healthy individuals requiring endodontic surgery who fulfilled all inclusion and exclusion criteria were selected and randomly placed in two groups. Surgical curettage of the bony lesion was performed and filled with hydroxyapatite graft. Amniotic membrane (Group 1) and platelet‐rich fibrin (Group 2) were placed over the bony crypt, and the flap was sutured back. The lesion's surface area and vascularity were the parameters assessed with ultrasound and color doppler. and observations: The groups found a significant difference in mean vascularity at 1 month and mean vascularity change from baseline to 1 month (p < 0.05). Mean surface area had no statistically significant difference between the groups. However, in terms of the percentage change in surface area, a significant difference was found from baseline to 6 months (p < 0.05). Amniotic membrane was a significantly better promoter of angiogenesis than platelet‐rich fibrin in the current trial. The osteogenic potential of both materials was similar. However, the clinical application, availability, and cost‐effectiveness of amniotic membrane support it as a promising therapeutic alternative in clinical translation. Further large‐scale trials and histologic studies are warranted.

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Composing On-Program Triggers and On-Demand Stimuli into Biosensor Drug Carriers in Drug Delivery Systems for Programmable Arthritis Therapy

Zaidi

Miskon

2022

Pharmaceuticals

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Medication in arthritis therapies is complex because the inflammatory progression of rheumatoid arthritis (RA) and osteoarthritis (OA) is intertwined and influenced by one another. To address this problem, drug delivery systems (DDS) are composed of four independent exogenous triggers and four dependent endogenous stimuli that are controlled on program and induced on demand, respectively. However, the relationships between the mechanisms of endogenous stimuli and exogenous triggers with pathological alterations remain unclear, which results in a major obstacle in terms of clinical translation. Thus, the rationale for designing a guidance system for these mechanisms via their key irritant biosensors is in high demand. Many approaches have been applied, although successful clinical translations are still rare. Through this review, the status quo in historical development is highlighted in order to discuss the unsolved clinical difficulties such as infiltration, efficacy, drug clearance, and target localisation. Herein, we summarise and discuss the rational compositions of exogenous triggers and endogenous stimuli for programmable therapy. This advanced active pharmaceutical ingredient (API) implanted dose allows for several releases by remote controls for endogenous stimuli during lesion infections. This solves the multiple implantation and local toxic accumulation problems by using these flexible desired releases at the specified sites for arthritis therapies.

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“Effect of local application of simvastatin in bone regeneration of peri-apical defects-a clinico-radiographic study

Cited by 4 publications

References 29 publications

Effect of Local Simvastatin on the Healing of Surgically Created Critical-Sized Bone Defects: An experimental Study on sheep.

Effect of Local Simvastatin on the Healing of Surgically Created Critical-Sized Bone Defects: An experimental Study on sheep.

Effect of amniotic membrane and platelet‐rich fibrin membrane on bone healing post endodontic surgery: An ultrasonographic, randomized controlled study

Composing On-Program Triggers and On-Demand Stimuli into Biosensor Drug Carriers in Drug Delivery Systems for Programmable Arthritis Therapy

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