Effect of local administration of simvastatin on orthodontic tooth movement in rabbits

AlSwafeeri, Hani; El-Kenany, Walid; Mowafy, Mohamed; Karam, Sahar S.

doi:10.1016/j.ajodo.2018.07.027

Cited by 13 publications

(26 citation statements)

References 41 publications

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“…Regarding the effect of statins on tooth movement in orthodontic treatment, reduction in the number of osteoclasts and the region of bone resorption has been reported (34,35) , and while effectiveness in preventing backtracking after orthodontic treatment has been reported (25,26) , tooth movement is said to be slowed (36) . However, in this study, by investigating the concentration of fluvastatin, locally administering a low concentration of 10 nM, and carrying out local administration without using carriers such as scaffolds, we showed that it is possible to carry out bone construction on the surface of the alveolar bone without inhibiting tooth movement.…”

Section: Discussionmentioning

confidence: 99%

“…In these reports, mainly through Extracellular Signalregulated Kinase (ERK) , Mitogenactivated Protein Kinase (MAPK) , Phosphoinositide 3kinase / Protein Kinase B (PI3 -Akt) , and Nuclear factor kappalightchainenhancer of activated B cells (NF-κB) pathways, they are thought to suppress periodontitis by inhibiting inflammatory cytokines and promoting the release of antiinflammatory and/or degradationpromoting molecules (19) . In the field of orthodontics, use for backtracking prevention after orthodontic treatment has been examined, and favorable results have been reported (25,26) . As problems in use in orthodontic treatment, when the arrangement of teeth protrudes from the alveolar bone housing, alveolar bone resorption as well as gingival recession may be given as incidental symptoms.…”

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confidence: 99%

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The Increase of Maxillary Lateral Expansion Limit by Local Application of Fluvastatin

2021

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Among hyperlipidemia patients, when total cholesterol and LDL cholesterol are high, arteriosclerosis develops and the risk of inducing myocardial infarction or cerebrovascular disorders increases. In the liver, cholesterol is produced by the action of HMG -CoA reductase, etc., and the cholesterol is transferred to each tissue or expelled in bile. Currently, statins are central among hyperlipidemia medicines. Statins are inhibitors of HMG -CoA reductase in the liver, and by suppressing cholesterol synthesis they have the effect of reducing blood cholesterol (1 -4) .In recent years, it has become clear that the effect of statins is not limited to inhibiting HMG -CoA reductase, but they also cause the promoters of Bone Morphogenetic Proteins -2 (BMP -2) to activate, controlling boneinducing ability by Smad Ubiquitination Regulatory Factor 2 (Smurf2) (5 -7) . In our previous research, we examined the effect of fluvastatin on endochondral ossification. In endochondral tissues, by inhibiting cholesterol modification of Indian Hedgehog (IHH) , statins caused IHH pathways to become active, changing localization of IHH (8) .These resulted in promotion of cell proliferation, increase in the hypertrophic chondrocyte layer, inhibiting apoptosis, and reduction in calcification, proving that it plays a positive role in long bone growth (9, 10) . To summarize, we believe that statins not only inhibit systemic LDL cho-Correspondence to：

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

The Increase of Maxillary Lateral Expansion Limit by Local Application of Fluvastatin

2021

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“…Consequently, five studies including a total number of 108 animals were included in the qualitative assessment (39)(40)(41)(42)(43), and three trials were considered in the quantitative analysis (40,41,43) (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…All the five included studies were randomized experimental trials (39)(40)(41)(42)(43), of which two cases had a split-mouth design (39,40). The other three trials used a parallel-arm design (41)(42)(43).…”

Section: Study Characteristicsmentioning

confidence: 99%

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The Effect of Statins on Orthodontic Tooth Movements: A Meta-analysis of Animal Studies

Afshari

Tahamtan

Shirban

2021

Avicenna J Dent Res

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Background: Statins are effective therapeutic agents for the treatment of cardiovascular diseases. Their favorable effects on various aspects of oral health including promising effects on bone metabolism and pleiotropic impacts such as anti-inflammatory properties made these drugs a current area of interest in the field of orthodontics. Therefore, the aim of this study was to evaluate the effects of statins on orthodontic tooth movement (OTM) in animals undergoing orthodontic treatments. Methods: Several databases were comprehensively searched for studies measuring the effects of statins on the OTM up to January 2020, including MEDLINE, ISI Web of Science, EMBASE, Scopus, and Cochrane. Animal studies evaluating the effects of statins on tooth movements in animals undergoing orthodontic treatments were selected based on the PICO model .Study selection, data extraction, risk of bias, and study quality assessment were independently performed by two reviewers. Finally, the data were analyzed using random-effects meta-analysis and the mean difference (MD) was used for comparing the outcome measures. Results: Three randomized trials were finally included in this meta-analysis. According to the Systematic Review Centre for Laboratory animal Experimentation Tool, all the included studies had at least one domain at a high risk of bias. The amount of the OTM was insignificantly lower in the statin group (MD = 0.134 mm, %95 confidence interval = -0.020-0.288, P>0.05). Conclusions: Due to the low quality and methodological inconsistencies among the included studies, conclusive confirmation regarding the effect of statins on the OTM remains debatable. Trail Registration: The protocol of this study was registered on PROSPERO (https://www.crd.york.ac.uk/ PROSPERO/) with the ID # CRD42020164155.

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Biological Orthodontics

Krishnan¹,

Davidovitch²,

Kuijpers-Jagtman³

2021

Biological Mechanisms of Tooth Movement

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Effect of local administration of simvastatin on orthodontic tooth movement in rabbits

Cited by 13 publications

References 41 publications

The Increase of Maxillary Lateral Expansion Limit by Local Application of Fluvastatin

The Increase of Maxillary Lateral Expansion Limit by Local Application of Fluvastatin

The Effect of Statins on Orthodontic Tooth Movements: A Meta-analysis of Animal Studies

Biological Orthodontics

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