In pipelines designed to laterally buckle, start-up and shut-down cycles result in significant axial cyclic stress ranges experienced at the buckle crown. The fatigue performance of girth welds in this high-stress low-cycle regime is therefore often a critical aspect of overall pipeline design. Although thermal cycling is usually intended to be entirely elastic, stress ranges may approach or even marginally exceed the uniaxial yield stress, particularly early in life. Under these conditions, material response may differ from that conventionally seen under low-stress high-cycle fatigue loading, such as that resulting from wave or VIV loading. In particular, the possibility of cyclic softening needs to be considered, and specific boundaries set to ensure such behaviour is avoided.The specific nature of the fatigue loading associated with lateral buckling, also presents a significant challenge when considering the likely corrosion fatigue performance of girth welds exposed to either seawater or sour produced fluids. Corrosion fatigue performance is known to depend on the frequency of cyclic loading, with lower frequency loading incurring greater fatigue damage in each cycle. Unfortunately the cyclic loading frequency associated with lateral buckling is very low (at least several hours per cycle) and this is beyond the range of conventional laboratory testing. Special techniques and methods of analysis are therefore needed to determine an appropriate fatigue life reduction factor for use in design. This paper presents the results of experimental work carried out to investigate these two critical aspects of material behaviour, and summarises the corresponding SAFEBUCK design guidance.