Effect of litter size on milk yield in the rat

Morag, M.; Popliker, F.; Yagil, R.

doi:10.1258/002367775780994844

Cited by 34 publications

(23 citation statements)

References 6 publications

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“…A longer starvation likely leads to a higher milk intake by the pups when they are allowed to suckle, but may also exacerbate offspring’s stress. On the other hand, the larger the litter, the higher the milk production [22]. The lower milk production of our dams determined using the WSW method could be explained by the smaller litter size (8 versus 12 to 14 in BAUTISTA et al [15] study).…”

Section: Discussionmentioning

confidence: 82%

Use of water turnover method to measure mother’s milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation

et al. 2017

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Assessment of milk production is of utmost relevance for pediatricians and scientists interested in early life nutrition. The weight-suckle-weight (WSW) method, which consists of weighing babies before and after they suckle their mother, uses the difference in body weight as an estimate of milk intake. However, this is prone to many sources of error. In the current study, we used for the first time the water turnover method and compartmental analysis with deuterated water (D2O) as a non-toxic tracer to quantify in vivo milk production in a rat model. We assessed the effect of a nutritional intervention presumed to affect milk production, a maternal dietary protein restriction during gestation and lactation, which results in the birth of pups with intrauterine growth restriction. The specific aim of this study was to determine milk production with the body water turnover method in rat dams receiving during gestation and lactation, either a control diet (NP) or an iso-caloric low-protein diet (LP). In NP dams, mass of dam’s total body water, output flow constant from dam to litter (K21) and median milk flow, calculated between days 11 to 14 after pup birth, were 282.1 g, 0.0122 h-1 and 3.30 g/h for NP dams, respectively. Maternal dietary protein restriction (-59%) during perinatal period led to a 34% reduction in milk flow (NP versus LP). With the WSW method, milk flow varied from 1.96 g/h to 2.37 g/h between days 11 to 14 for NP dams. The main advantage of the D20 method compared to the WSW method stems from its higher precision, as attested by the narrowest range of measured values of milk flow ([2.90; 3.75] and [0.98; 6.85] g/h, respectively) for NP group. This method could be suitable for testing the effectiveness of candidate galactologue molecules presumed to enhance milk production in the lactating rat model.

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Section: Discussionmentioning

confidence: 82%

Use of water turnover method to measure mother’s milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation

et al. 2017

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“…Milk yield estimations for rats by means of pup weight and weight gains have been used in several studies (Morag et al 1975, Sampson & Jansen 1984, Kamani et al 1987, Kim et al 1998. It has to be noted that the purpose of this study was essentially to determine whether AN extract is lactogenic.…”

Section: Discussionmentioning

confidence: 99%

Effect of aqueous extract of Acacia nilotica ssp adansonii on milk production and prolactin release in the rat

Lompo-Ouedraogo¹,

Heide²,

Beek³

et al. 2004

Journal of Endocrinology

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In view of the traditional belief that Acacia nilotica ssp adansonii (AN) can stimulate milk production in lactating women, experiments were performed to determine the effect of an aqueous extract of AN on milk production in rats. Female rats that received oral doses of aqueous extract of this plant during their first lactation produced about 59% more milk than controls (P<0·01). Pup weight gain was also significantly higher than that in the control group. A lower dose, comparable to that used by women to improve their milk yield, led to about 33% more milk with the same growth rate for pups as that in the high-dose group. The extract of AN was found to stimulate the synthesis and release of prolactin (PRL) significantly (P<0·05). In addition, the mammary glands of oestrogenprimed rats treated with the extract showed clear lobuloalveolar development with milk secretion. This study demonstrates that the aqueous extract of AN can stimulate milk production and PRL release in the female rat and could consequently have the properties claimed for lactating women.

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“…Some showed that increasing the number of pups per litter caused an increase in milk yield (Reddy & Donker, 1964;Edwardson & Eayrs. 1967;Kumaresan, Anderson & Turner, 1967;Morag, Popliker & Yagil, 1975) although the capacity of the rat to secrete milk is limited. Morag (1970) observed that the maximum milk production in rats (6% of the total bodyweight) occurred in litters containing 10 or 12 pups.…”

Section: Discussionmentioning

confidence: 99%

The influence of litter size and favourable conditions on mortality and weaning weights in rats

Kahan

Rosen

1984

Lab Anim

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Effect of litter size on milk yield in the rat

Cited by 34 publications

References 6 publications

Use of water turnover method to measure mother’s milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation

Use of water turnover method to measure mother’s milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation

Effect of aqueous extract of Acacia nilotica ssp adansonii on milk production and prolactin release in the rat

The influence of litter size and favourable conditions on mortality and weaning weights in rats

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