Effect of Lithium upon Lipid Metabolism in Rats

Fleischman, Alan I.; Lenz, Paul H.; Bierenbaum, Marvin L.

doi:10.1093/jn/104.10.1242

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…This reduction may reflect a liver effect of the lithium. In this regard, lithium decreased total lipids, unesterified fatty acids and triglycerides in the rat liver (Fleischman et al 1974); and circulating unesterified fatty acids are derived by hydrolysis of esterified fatty acids that are secreted by the liver and adipose tissue (Gao et al 2009; Gibbons et al 2004; Purdon et al 1997). These results are not consistent with other studies using F344/Ducrl rats under a 5001 diet containing alfalfa and fishmeal (Basselin et al 2007; Chang et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Chronic Lithium Feeding Reduces Upregulated Brain Arachidonic Acid Metabolism in HIV-1 Transgenic Rat

Ramadan

Basselin

Chang

et al. 2012

J Neuroimmune Pharmacol

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Background HIV-1 transgenic (Tg) rats, a model for human HIV-1 associated neurocognitive disorder (HAND), show upregulated markers of brain arachidonic acid (AA) metabolism with neuroinflammation after 7 months of age. Since lithium decreases AA metabolism in a rat lipopolysaccharide model of neuroinflammation, and may be useful in HAND, we hypothesized that lithium would dampen upregulated brain AA metabolism in HIV-1 Tg rats. Methods Regional brain AA incorporation coefficients k* and rates Jin, markers of AA signaling and metabolism, were measured in 81 brain regions using quantitative autoradiography, after intravenous [1-14C] AA infusion in unanesthetized 10-month-old HIV-1 Tg and age-matched wildtype rats that had been fed a control or LiCl diet for 6 weeks. Results k* and Jin for AA were significantly higher in HIV-1 Tg than wildtype rats fed the control diet. Lithium feeding reduced plasma unesterified AA concentration in both groups and Jin in wildtype rats, and blocked increments in k* (19 of 54 regions) and Jin (77 of 81 regions) in HIV-1 Tg rats. Conclusion These in vivo neuroimaging data indicate that lithium treatment dampened upregulated brain AA metabolism in HIV-1 Tg rats. Lithium may improve cognitive dysfunction and be neuroprotective in HIV-1 patients with HAND through a comparable effect.

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Section: Discussionmentioning

confidence: 99%

Chronic Lithium Feeding Reduces Upregulated Brain Arachidonic Acid Metabolism in HIV-1 Transgenic Rat

Ramadan

Basselin

Chang

et al. 2012

J Neuroimmune Pharmacol

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“…Epidemiological studies have suggested that lithium may protect against the development of cardiovascular disease (85). Lithium is believed to stimulate triglyceride metabolism with a concomitant increase in serum concentrations of free fatty acids (21).…”

Section: Lithiummentioning

confidence: 99%

Trace Elements and Public Health

Calabrese¹

1985

Annual Review of Public Health

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“…Several diseases such as reproductive problems, shorter life spans, poor lipid metabolism, and behavioral abnormalities are caused by the deficiency of lithium [23,24]. Lithium is a potential agent for the treatment of Alzheimer's disease.…”

Section: Resultsmentioning

confidence: 99%

Quantification of Mineral Elements of Rheum emodi Wallr. (Polygonaceae)

Singh

Negi

Rawat

et al. 2010

Biol Trace Elem Res

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Present investigation was carried out to estimate mineral elements in Rheum emodi Wallr. by atomic absorption spectroscopy. The samples of R. emodi Wallr., both wild and cultivate populations, were collected from different localities at different altitudes of Uttarakhand, India. The concentration of micro- and macroelements was different in roots and leaves. The concentration of mineral elements was found in both the leaves and roots in the order of K > Ca > Fe > Mn > Na > Zn > Co > Li > Cu.

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Effect of Lithium upon Lipid Metabolism in Rats

Cited by 13 publications

References 5 publications

Chronic Lithium Feeding Reduces Upregulated Brain Arachidonic Acid Metabolism in HIV-1 Transgenic Rat

Chronic Lithium Feeding Reduces Upregulated Brain Arachidonic Acid Metabolism in HIV-1 Transgenic Rat

Trace Elements and Public Health

Quantification of Mineral Elements of Rheum emodi Wallr. (Polygonaceae)

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