Effect of lisdexamfetamine on emotional network brain dysfunction in binge eating disorder

Fleck, David E.; Eliassen, James C.; Guerdjikova, Anna I.; Mori, Nicole; Williams, Stephanie; Blom, Thomas J.; Beckwith, Travis; Tallman, Maxwell J.; Adler, Caleb M.; DelBello, Melissa P.; Strakowski, Stephen M.; McElroy, Susan L.

doi:10.1016/j.pscychresns.2019.03.003

Cited by 26 publications

(39 citation statements)

References 43 publications

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“…161 Furthermore, in individuals with BED, changes in prefrontal brain systems associated with LDX treatment were related to treatment outcome. 162 Specifically, reductions in brain activation in the ventromedial prefrontal cortex and thalamus while viewing food pictures after LDX correlated with reductions in binge eating and compulsivity symptoms. 162 Research investigating short-term and long-term effects of LDX, alone and in combination with cognitive behavioral therapy, is ongoing.…”

Section: Stimulant Medications: Dual Effects On Executive Function Anmentioning

confidence: 94%

“…162 Specifically, reductions in brain activation in the ventromedial prefrontal cortex and thalamus while viewing food pictures after LDX correlated with reductions in binge eating and compulsivity symptoms. 162 Research investigating short-term and long-term effects of LDX, alone and in combination with cognitive behavioral therapy, is ongoing. 163,164 Research has recently tested dasotraline, an agent that inhibits dopamine and norepinephrine transporters with stimulant effects, 165 for treating BED.…”

Section: Stimulant Medications: Dual Effects On Executive Function Anmentioning

confidence: 94%

See 1 more Smart Citation

The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics

Boswell

Potenza

Grilo

2021

Clinical Therapeutics

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Section: Stimulant Medications: Dual Effects On Executive Function Anmentioning

confidence: 94%

Section: Stimulant Medications: Dual Effects On Executive Function Anmentioning

confidence: 94%

The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics

Boswell

Potenza

Grilo

2021

Clinical Therapeutics

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“…Thus, there are few animal studies overall, but particularly in the impulsivity domain, as well as a relative lack of studies attempting to directly replicate rodent findings in humans or vice versa. Likewise, there are few neurofunctional investigations, despite growing evidence of substantial neurostructural and neurochemical alterations in BED (Cambridge et al, 2013;Dodds et al, 2012;Filbey et al, 2012;Fleck et al, 2019;Joutsa et al, 2018;Majuri et al, 2017Majuri et al, , 2016Schäfer et al, 2010;Wang et al, 2011).…”

Section: Translational Myopiamentioning

confidence: 99%

Loss of control over eating: A systematic review of task based research into impulsive and compulsive processes in binge eating

Waltmann¹,

Herzog²,

Horstmann³

et al. 2021

Preprint

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Recurring episodes of excessive food intake in binge eating disorder can be understood through the lens of behavioral control systems: patients repeat maladaptive behaviors against their explicit intent. Self-report measures show enhanced impulsivity and compulsivity in binge eating (BE). Task-based neurocognitive investigations can tap into processes that lead to such lapses of control. In this systematic review, we synthesize the insights into processes relevant to BE provided by neurocognitive research on behavioral impulsivity and compulsivity in BE in humans and animals, published between 2010-2020. Findings on impulsivity are heterogeneous. Findings on compulsivity are sparse but comparatively consistent, indicating an imbalance of goal-directed and habitual control as well as deficits in reversal learning. We propose to address heterogeneity related to mood states and the temporal dynamics of symptoms and to systematically differentiate contributions of body weight and BE. It is necessary to ascertain the reliability of the metrics employed to further scrutinize the compulsivity findings in order to unravel the computational mechanisms of a potential reinforcement learning deficits.

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“…Fleck et al (16) have shown that a treatment with LDX of women with BED reduced activity in the globus pallidus and ventromedial prefrontal cortex (VMPFC). Studies on menopausal women showed that the drug modulated insula and dorsolateral prefrontal cortex (DLPC) recruitment (17).…”

Section: Introductionunclassified

Lisdexamfetamine alters BOLD-fMRI activations induced by odor cues in impulsive children

Hidalgo-Tobón

Suárez²,

Pérez³

et al. 2020

Preprint

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Introduction: Lisdexamfetamine (LDX) is a drug used to treat ADHD/impulsive patients. Impulsivity is known to affect inhibitory, emotional and cognitive function. On the other hand, smell and odor processing are known to be affected by neurological disorders, as they are modulators of addictive and impulsive behaviors specifically. We hypothesize that, after LDX ingestion, inhibitory pathways of the brain would change, and complementary behavioral regulation mechanisms would appear to regulate decision-making and impulsivity.Methods: 20 children were studied in an aleatory crossover study. Imaging of BOLD-fMRI activity, elicited by olfactory stimulation in impulsive children, was performed after either LDX or placebo ingestion. Results:Findings showed that all subjects that underwent odor stimulation presented activations of similar intensities in the olfactory centers of the brain. This contrasted with inhibitory regions of the brain such as the cingulate cortex and frontal lobe regions, which demonstrated changed activity patterns and intensities. While some differences between the placebo and medicated states were found in motor areas, precuneus, cuneus, calcarine, supramarginal, cerebellum and posterior cingulate cortex, the main changes were found in frontal, temporal and parietal cortices. When comparing olfactory cues separately, pleasant food smells like chocolate seemed not to present large differences between the medicated and placebo scenarios, when compared to non-food-related smells. Conclusions:We demonstrated that LDX, first, altered the inhibitory pathways of the brain, second, increased activity in large amounts of brain regions which were not activated by smell in drug-naïve patients, third, facilitated a complementary behavioral regulation mechanism, run by the cerebellum, which regulated decision-making and impulsivity in motor and frontal structures.

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Effect of lisdexamfetamine on emotional network brain dysfunction in binge eating disorder

Cited by 26 publications

References 43 publications

The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics

The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics

Loss of control over eating: A systematic review of task based research into impulsive and compulsive processes in binge eating

Lisdexamfetamine alters BOLD-fMRI activations induced by odor cues in impulsive children

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