Effect of Liquid Diphenoxylate Hydrochloride and Atropine Sulfate (Lomotil) Instillations on Dynamics and Function of Continent Cecal Urinary Reservoirs

Fowler, Jackson E.; Clayton, Michael; Mouli, K.; Reagan, Gary

doi:10.1016/s0022-5347(17)43356-8

Cited by 15 publications

(2 citation statements)

References 7 publications

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“…In the literature there are only few reports about the effects of drugs on the dynamics of cecal urinary reservoir [Fowler et al, 1987;Mansson et al, 19891. Stimulation of muscarinic receptor has been described in various mammalian species to enhance the motility of the bowel and blockade of the receptor to abolish it [Bolton, 1981;Kirk, 1981;Scratched et al, 19861. So it was not surprising that bethanechol increased reservoir's motor activity and decreased the capacity.…”

Section: Discussionmentioning

confidence: 99%

Effects of atropine, glucagon, and bethanechol on urodynamics of continent cecal urinary reservoir before and after complete, partial, and sham detubularizations in dog

Tammela

Kiiholma

1993

Neurourology and Urodynamics

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Effects of muscarinic receptor blockade (atropine), stimulation (bethanechol), and bowel smooth muscle relaxant (glucagon) on the urodynamics of the continent cecal urinary reservoir in a tube form and after complete, partial, and sham detubularizations were studied using dogs. Complete detubularization significantly increased capacity and decreased spontaneous motor activity, whereas the other types of detubularization had no significant effects on them. Neither atropine nor glucagon had influence on the basal pressure, but they increased the capacity and the volume at which the first pressure wave appeared and decreased the wave amplitude. After detubularization glucagon further decreased uninhibited contractions while atropine totally abolished them. The highest capacity and lowest motor activity was gained when atropine or glucagon was given in cases with detubularized pouch demonstrating an additive effect of the detubularization and drug. Also, bethanechol increased the motor activity and decreased the volume in detubularized pouches. It is suggested that when hyperactivity of intestinal reservoir is a problem in a patient with a detubularized cecal pouch, orally administered anticholinergic or bowel smooth muscle relaxing drugs may be useful in management. 8 1993 Wiky-Lis\. Inc

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Section: Discussionmentioning

confidence: 99%

Effects of atropine, glucagon, and bethanechol on urodynamics of continent cecal urinary reservoir before and after complete, partial, and sham detubularizations in dog

Tammela

Kiiholma

1993

Neurourology and Urodynamics

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“…In continent cecal urinary reservoirs atropine sulfate has been shown to reduce the frequency of spontaneous contractions and to restore continence in patients with urinary leakage [7]. The use of anticholinergic drugs has also provided a useful therapeutic approach to reduce stool frequency in patients with proctocolectomy and ileal pouch-anal anastomosis.…”

Section: Introductionmentioning

confidence: 99%

Does Botulinum Type-A Toxin Affect Motor Activity after Proctocolectomy and Ileal Pouch-Anal Anastomosis?

Willis¹,

Felbert²,

Hölzl³

et al. 2004

Eur Surg Res

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Aim of the Study: The use of anticholinergic drugs has provided a useful therapeutic approach to reduce stool frequency in patients with proctocolectomy and ileal pouch-anal anastomosis (IPAA). Botulinum type-A (BTA) toxin has been shown to specifically block acetylcholine release in the intestinal wall. Therefore this study investigated the effect of BTA on small intestinal and J-pouch motility after IPAA. Material and Methods: Proctocolectomy and IPAA were performed in 4 dogs. The motility of the small intestine and the ileal pouch was recorded by serosal electrodes and strain gauge transducers. The intestinal transit time was determined radiologically and pouch compliance was determined manometrically. Multiple measurements were performed before and after endoscopic injection of BTA into the pouch wall. Results: This treatment did not significantly influence stool frequency, intestinal transit time or pouch compliance. Intrinsic pouch motility was characterized by irregular contractions, the amplitudes and frequencies of which remained unchanged after BTA administration. With the exception of lower contraction amplitudes directly proximal to the pouch, there were no significant differences in the characteristics of the migrating myoelectric complex or in the fed pattern of the small intestine and ileal pouch. Conclusions: BTA does not significantly affect ileal pouch motility. The beneficial effects of anticholinergic drugs therefore seem to be due to their multifactorial mode of action and not to the inhibition of cholinergic neurons in the pouch.

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Cystectomy and Bladder Reconstruction for Bladder Cancer

Seemann¹,

Alken²

1994

Tumours in Urology

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Effect of Liquid Diphenoxylate Hydrochloride and Atropine Sulfate (Lomotil) Instillations on Dynamics and Function of Continent Cecal Urinary Reservoirs

Cited by 15 publications

References 7 publications

Effects of atropine, glucagon, and bethanechol on urodynamics of continent cecal urinary reservoir before and after complete, partial, and sham detubularizations in dog

Effects of atropine, glucagon, and bethanechol on urodynamics of continent cecal urinary reservoir before and after complete, partial, and sham detubularizations in dog

Does Botulinum Type-A Toxin Affect Motor Activity after Proctocolectomy and Ileal Pouch-Anal Anastomosis?

Cystectomy and Bladder Reconstruction for Bladder Cancer

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