Effect of lipoic acid administration on gentamicin‐induced lipid peroxidation in rats

Sandhya, P.; Varalakshmi, P.

doi:10.1002/(sici)1099-1263(199711/12)17:6<405::aid-jat459>3.3.co;2-v

Cited by 10 publications

(11 citation statements)

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“…However, significant (P < 0.05) decreases in the LPO level were observed by the administration of all doses of ALA, LAN, and RAN. The results of previous studies were also in line with our data (Sandhya and Varalakshmi 1997;Dincer and others 2002).…”

Section: Resultssupporting

confidence: 93%

Alpha‐Lipoic Acid Protects against Indomethacin‐Induced Gastric Oxidative Toxicity by Modulating Antioxidant System

Kaplan¹,

Odabaşoğlu²,

Halıcı³

et al. 2012

Journal of Food Science

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Gastroprotective effects of α-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems.

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Section: Resultssupporting

confidence: 93%

Alpha‐Lipoic Acid Protects against Indomethacin‐Induced Gastric Oxidative Toxicity by Modulating Antioxidant System

Kaplan¹,

Odabaşoğlu²,

Halıcı³

et al. 2012

Journal of Food Science

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“…These changes of membrane lipid composition may be induced by free radical-initiated lipid peroxidation. 46) This view is supported by increased MDA levels, one of the products of lipid peroxidation, in GM treated rats kidney. 47,48) We have found elevated lipid peroxide levels (TBARS) in the GM treated group, consistent with previous studies mentioned.…”

Section: Discussionmentioning

confidence: 89%

Protective Effect of Quercetin against Gentamicin-Induced Nephrotoxicity in Rats

Abdel-Raheem

Abdelghany

Mohamed

2009

Biological & Pharmaceutical Bulletin

152

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Gentamicin (GM) is an antibiotic widely used in treating severe gram-negative infections. However, its clinical use is limited by its nephrotoxicity. Several lines of evidence indicate that free radicals are important mediators of gentamicin nephrotoxicity. Therefore, the aim of this work was to investigate the possible protective effect of the flavonoid quercetin, an antioxidant, on gentamicin-induced nephrotoxicity. For this purpose, rats were divided into four groups. First group served as a control and injected with the normal saline, second group was injected with quercetin (50 mg/kg/d, per os) for 7 d, third group was injected with gentamicin (80 mg/kg/d, intraperitoneally) for 7 d and the fourth group of animals was injected with quercetin plus gentamicin simultaneously for 7 d. Total protein levels were estimated in 24-h urine samples to assess kidney dysfunction. The rats were sacrificed on the seventh day and kidneys were collected for histopathological studies. Blood urea nitrogen (BUN) and creatinine levels were measured in the blood. Moreover, glutathione (GSH), lipid peroxide (TBARS) levels, superoxide dismutase (SOD) and catalase (CAT) activities were determined in renal tissues. GM-treated rats showed early kidney dysfunction as urinary total protein, BUN and serum creatinine levels were significantly increased. The significant decrease in GSH levels, SOD, CAT activities and increase in TBARS levels, indicated that GMinduced nephrotoxicity was mediated through oxidative stress reactions. Histopathological examination of GM-treated rats revealed degenerative changes in glomeruli and tubules. On the other hand, simultaneous administration of quercetin plus gentamicin protected kidney tissues against nephrotoxic effects of gentamicin as evidenced from amelioration of histopathological changes and normalization of kidney biochemical parameters.

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“…These changes of membrane lipid composition may be induced by free radical-initiated lipid peroxidation. 41,42) This view is supported by increased MDA levels, one of the aldehydic products of lipid peroxidation, in GEN treated rats kidney. [42][43][44][45] We have found elevated lipid peroxidation in the GEN treated group, consistent with previous studies mentioned.…”

Section: Discussionmentioning

confidence: 98%

Gentamicin-Induced Nephrotoxicity in Rats Ameliorated and Healing Effects of Resveratrol

Silan¹,

Uzun²,

Çomunoglu

et al. 2007

Biological & Pharmaceutical Bulletin

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Effect of lipoic acid administration on gentamicin‐induced lipid peroxidation in rats

Cited by 10 publications

References 0 publications

Alpha‐Lipoic Acid Protects against Indomethacin‐Induced Gastric Oxidative Toxicity by Modulating Antioxidant System

Alpha‐Lipoic Acid Protects against Indomethacin‐Induced Gastric Oxidative Toxicity by Modulating Antioxidant System

Protective Effect of Quercetin against Gentamicin-Induced Nephrotoxicity in Rats

Gentamicin-Induced Nephrotoxicity in Rats Ameliorated and Healing Effects of Resveratrol

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