Effect of Lipid Modification on Progression of Coronary Calcification

McCullough, Peter A.

doi:10.1681/asn.2005060664

Cited by 29 publications

(20 citation statements)

References 25 publications

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“…We speculated that greater use of sevelamer might have contributed to a potential benefit on the CAC process in these patients. A few studies have demonstrated that progressive CAC can be largely abolished by the use of sevelamer in place of CBPBs [11,12,25,39,40]. Also, the CACS increased in our three patients on dialysis (patients 1, 2 and 3).…”

Section: Discussionsupporting

confidence: 50%

“…In our study progression of CAC was associated with baseline levels of total cholesterol, baseline and final levels of LDL-cholesterol, and final serum albumin levels in univariate analysis. In several studies of adults with CKD, dyslipidemia, such as increased triglyceride level, total cholesterol and LDL-cholesterol levels or decreased highdensity lipoprotein (HDL)-cholesterol level, has been implicated in the progression of CAC [25,39,46,47]. The results of the Treat to Goal Study [11] suggest that the lowering of LDL-cholesterol level in adults with ESRD may also result in amelioration of the progression of CAC.…”

Section: Discussionmentioning

confidence: 99%

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Progression of coronary calcification in pediatric chronic kidney disease stage 5

et al. 2009

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Coronary artery calcification (CAC) is common in adults with chronic kidney disease (CKD) and progresses with time. However, data are limited for younger patients. We have previously reported CAC in eight of 53 children with CKD. After 2 years, CAC evaluation was repeated in 48 patients. The median CAC score (CACS) increased from 101.3 (1473.6 +/- 1978.6, range 8.5-4332) to 1759.2 (2236.4 +/- 2463.3, range 0-5858) Agatston units (AU). When the individual changes in CACS were evaluated one by one, we showed a mild decrease in two patients on hemodialysis (HD) and in one transplant (Tx) recipient, a moderate increase in one patient on HD, one on peritoneal dialysis (PD) and one Tx recipient, and a large increase in one HD patient. Also, CAC disappeared in one HD patient. All patients with no calcification at baseline remained calcification-free at follow-up. To obtain the individual cumulative exposure, we calculated time-averaged mean values, using the laboratory values from the beginning of dialysis to the first and second multidetector spiral computed tomography (MDCT) scans (baseline and final values, respectively). Final CACS was positively related to final calcium-phosphorus (CaxP) product, while CAC progression was inversely associated with final serum albumin level. This report is the first study with the largest number and the youngest cohort to document the natural history of coronary calcification.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Progression of coronary calcification in pediatric chronic kidney disease stage 5

et al. 2009

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“…Age, sex, smoking, hypertension, dyslipidemia, chronic kidney disease, diabetes and hyperglycemia are all known risk factors for developing CAC [6,7,8]. However, it is still unclear whether dietary factors are significant independent risk factors for developing CAC.…”

Section: Introductionmentioning

confidence: 99%

Composition of Dietary Macronutrient Intake Is Not Associated with Prevalence of Coronary Artery Calcification in Healthy Korean Adults

Sung

Byrne

et al. 2014

Ann Nutr Metab

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Background and Aims: There is little information supporting the relationships between macronutrients and pre-clinical atherosclerosis. The aim of this study was to identify whether dietary macronutrient content is related with CAC. Methods: 10,793 healthy Korean adults in a cohort were enrolled. Subjects were divided into CAC (CAC score >0) or non-CAC group (CAC score = 0). Intake of energy, carbohydrate (CHO), protein and fat were obtained using food frequency questionnaire (FFQ). Macronutrient composition was expressed as the ratio of energy from each macronutrient to total energy. Subjects were classified into three groups according to tertiles of intake for each macronutrient. To investigate the association between macronutrient intake and CAC, multiple regression analysis was conducted according to tertile groups of each macronutrient. Results: The prevalence of CAC significantly differed among tertile groups of CHO and fat intake in men (p < 0.001, p < 0.01) and women (p < 0.05, p < 0.01). However, multiple logistic regression analysis revealed that the odds ratios (ORs) for CAC were not significantly different among tertile groups of each macronutrient intake after adjustment in men (CHO: OR = 0.965 [95% CI = 0.826-1.129]; protein: OR = 1.029 [95% CI = 0.881-1.201]; fat: OR = 1.015 [95% CI = 0.868-1.188]) and women (CHO: OR = 1.158 [95% CI = 0.550-2.438]; protein: OR = 1.261 [95% CI = 0.629-2.528]; fat: OR = 0.625 [95% CI = 0.286-1.365]). Conclusions: The prevalence of CAC may not be associated with composition of dietary macronutrient intake in in healthy Korean adults. © 2014 S. Karger AG, Basel

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“…Zu den Risikofaktoren einer Atherosklerose werden hohe Gesamtcholesterin-, hohe LDL-Cholesterin-, niedrige HDLCholesterin-sowie hohe Triglyceridspiegel im Blut gerechnet [13]. Laut einem Bericht der Centers for Disease Control and Prevention (CDC) sollen im Jahr 2009 in den USA 76% der Bevölkerung im Alter von 18 Jahren oder älter hinsichtlich hoher Cholesterinwerte gescreent worden sein.…”

Section: Ldl- Und Hdl-cholesterinunclassified