Effect of lipid-based nutrient supplements on micronutrient status and hemoglobin among children with stunting: secondary analysis of a randomized controlled trial in Uganda

Mutumba, Rolland; Pesu, Hannah; Mbabazi, Joseph; Greibe, Eva; Nexo, Ebba; Olsen, Mette F; Briend, André; Mølgaard, Christian; Michaelsen, Kim F; Ritz, Christian; Filteau, Suzanne; Mupere, Ezekiel; Friis, Henrik; Grenov, Benedikte

doi:10.1016/j.ajcnut.2024.01.018

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Children that are stunted sometimes have anemia and shortages in certain micronutrients (Mutumba et al, 2024). In order to address the issue of stunting cases in Indonesia, the Ministry of Maritime Affairs and Fisheries is directed by Presidential Instruction (INPRES) No.…”

Section: Introductionmentioning

confidence: 99%

Improving the Nutritional Status of Stunted Children through Providing Additional Fish-Based Food

Nugroho,

Defriansya,

Andriani

et al. 2024

Indones. J. Heal. Res. Dev.

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For toddlers who are stunted, processed fish food can be utilized as an additional source of healthy nutrients. This study set out to assess how supplementing fish-based meals affected the nutritional status of toddlers who were stunted. 37 stunted toddlers in Lubuklinggau City received Additional Fish-Based Food for ninety days, from September to December 2023, as part of the study's sample. This research approach used an experimental design with a pre- and post-test strategy without control. Pairwise comparison tests were employed to do statistical analysis by evaluating the nutritional status of toddlers prior to and following the intervention. The research will be finished by December 2023. 6 (16.21%) of the toddlers had improved to a normal nutritional state, according to the data. The nutritional status of toddlers differed significantly before and after the intervention, as evidenced by a p-value of 0.000 (0.05). Thus, it can be said that giving toddlers extra fish-based meal treatments for ninety days can enhance their nutritional status and lower the incidence of stunting in the toddlers who are the target population.

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Section: Introductionmentioning

confidence: 99%

Improving the Nutritional Status of Stunted Children through Providing Additional Fish-Based Food

Nugroho,

Defriansya,

Andriani

et al. 2024

Indones. J. Heal. Res. Dev.

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Associations of micronutrients and lipids with prediabetes and glycemic parameters in adolescent girls of the rural DERVAN cohort (DERVAN-9)

Patil,

Dervankar,

Hardikar-Bhat

et al. 2024

Front. Nutr.

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BackgroundWe investigated the associations of micronutrients and lipids with prediabetes, glycemic parameters, and glycemic indices among the adolescent girls of the DERVAN (aDolescent and prEconception health peRspectiVe of Adult Non-communicable diseases) cohort study from rural India.MethodsWe recruited 1,520 adolescent girls aged 16–18 years. We measured glycemic parameters (glucose, insulin and HbA1C), lipids (total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides), and micronutrients (vitamin B12, folate, and vitamin D). Prediabetes was defined using American Diabetes Association criteria (fasting glucose ≥100 mg/dL or HbA1C ≥5.7%). Glycemic indices (insulin resistance, insulin sensitivity, and β cell function) were calculated using the homeostasis model. Associations of prediabetes, glycemic parameters and glycemic indices with micronutrients and lipids were analyzed by multiple logistic regressions.ResultsThe median age and Body Mass Index (BMI) were 16.6 years and 17.6 kg/m2, respectively. Overall, 58% of girls had a low BMI. Median vitamin B12, folate, and vitamin D concentrations were 249.0 pg/mL, 6.1 ng/mL, and 14.2 ng/mL, respectively. The deficiencies observed were 32.1% for vitamin B12, 11.8% for folate, and 33.0% for vitamin D. Median total cholesterol, LDL, HDL, and triglyceride concentrations were 148.0 mg/dL, 81.5 mg/dL, 50.8 mg/dL, and 61.5 mg/dL, respectively. Elevated total cholesterol, LDL, and triglycerides were observed in 4.8, 4.0, and 3.8%, respectively, while low HDL was observed in 12.8%. Prediabetes was observed in 39.7% of the girls. Among lipids, total cholesterol and LDL were higher in girls with prediabetes (p < 0.01 for both). In a multivariate model containing cholesterol and vitamin B12/folate/vitamin D, prediabetes was associated with high cholesterol. Prediabetes was also associated with high LDL, independent of folate and vitamin D. Poor insulin secretion was high in those with low vitamin B12. Elevated insulin resistance was associated with low HDL. The likelihood of high insulin sensitivity was reduced in those with high triglycerides. The likelihood of poor β cell function was high in those with high LDL. Statistical interactions between micronutrients and lipids for prediabetes and glycemic outcomes were not significant.ConclusionThere was a substantial deficiency of micronutrients and an absence of dyslipidemia. Our results indicate the need for lipid and micronutrient-based interventions in adolescence to improve glycemic outcomes. Maintaining adequate storage of not only micronutrients but also lipids in adolescent girls is likely to reduce diabetes risk in adulthood.

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Malnutrition and Allergies: Tipping the Immune Balance towards Health

Vassilopoulou,

Venter,

Roth-Walter

2024

JCM

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Malnutrition, which includes macro- and micronutrient deficiencies, is common in individuals with allergic dermatitis, food allergies, rhinitis, and asthma. Prolonged deficiencies of proteins, minerals, and vitamins promote Th2 inflammation, setting the stage for allergic sensitization. Consequently, malnutrition, which includes micronutrient deficiencies, fosters the development of allergies, while an adequate supply of micronutrients promotes immune cells with regulatory and tolerogenic phenotypes. As protein and micronutrient deficiencies mimic an infection, the body’s innate response limits access to these nutrients by reducing their dietary absorption. This review highlights our current understanding of the physiological functions of allergenic proteins, iron, and vitamin A, particularly regarding their reduced bioavailability under inflamed conditions, necessitating different dietary approaches to improve their absorption. Additionally, the role of most allergens as nutrient binders and their involvement in nutritional immunity will be briefly summarized. Their ability to bind nutrients and their close association with immune cells can trigger exaggerated immune responses and allergies in individuals with deficiencies. However, in nutrient-rich conditions, these allergens can also provide nutrients to immune cells and promote health.

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Effect of lipid-based nutrient supplements on micronutrient status and hemoglobin among children with stunting: secondary analysis of a randomized controlled trial in Uganda

Cited by 3 publications

References 34 publications

Improving the Nutritional Status of Stunted Children through Providing Additional Fish-Based Food

Improving the Nutritional Status of Stunted Children through Providing Additional Fish-Based Food

Associations of micronutrients and lipids with prediabetes and glycemic parameters in adolescent girls of the rural DERVAN cohort (DERVAN-9)

Malnutrition and Allergies: Tipping the Immune Balance towards Health

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