Effect of linseed oil supplementation on concentrations of (n‐3) polyunsaturated fatty acids in liver phospholipids of rats fed diets containing either an oil rich in conjugated linoleic acids, sunflower oil or high‐oleic acid sunflower oil

Eder, Klaus; Slomma, Nadine; Becker, K.; Brandsch, Corinna

doi:10.1111/j.1439-0396.2004.00510.x

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…1.36 ± 0.23 a 1. CLA studies performed with rodents because of differences in dietary CLA concentrations (Stangl, 2000a,b;Eder et al, 2005). However, percentages of trans-10, cis-12 CLA in liver lipids observed in this study are in agreement with those observed in tissue lipids of heifers fed similar amounts of rumen-protected CLA (Gillis et al, 2004a(Gillis et al, , 2007Poulson et al, 2004).…”

Section: Discussionsupporting

confidence: 86%

“…As expected, feeding the rumen‐protected CLA supplement to the heifers resulted in a dose‐dependent increase in the concentration of trans‐10, cis‐12 CLA in hepatic total lipids. Nevertheless, percentages of trans‐10, cis‐12 CLA in liver total lipids of heifers supplemented with CLA, being in the range between 0.08% and 0.12%, are relatively low compared with those observed in most CLA studies performed with rodents because of differences in dietary CLA concentrations (Stangl, 2000a,b; Eder et al., 2005). However, percentages of trans‐10, cis‐12 CLA in liver lipids observed in this study are in agreement with those observed in tissue lipids of heifers fed similar amounts of rumen‐protected CLA (Gillis et al., 2004a, 2007; Poulson et al., 2004).…”

Section: Discussionmentioning

confidence: 85%

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Effect of a rumen‐protected conjugated linoleic acid mixture on hepatic lipid metabolism in heifers

Shibani

Schlegel

Most

et al. 2011

Animal Physiology Nutrition

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This study was performed to assess the effects of rumen-protected conjugated linoleic acid (CLA) on hepatic lipid metabolism in heifers. In particular, it was of interest whether feeding CLA causes development of fatty liver as observed recently in mice. Thirty-six growing heifers with an initial body weight of 185 kg were allotted to three treatment groups and fed daily 250 g of different rumen-protected fats for 16 weeks: The control group received 250 g of a CLA-free control fat, the CLA100 group received 100 g of a CLA fat containing 2.4% of cis-9, trans-11 CLA and 2.1% of trans-10, cis-12 CLA and 150 g control fat and the CLA250 group received 250 g of the CLA fat. CLA supplementation had no effect on animal performance parameters, liver weight and hepatic triglyceride concentration. Moreover, mRNA expression of hepatic genes involved in lipogenesis, β-oxidation and fatty acid transport was not influenced by dietary CLA. The fatty acid composition of hepatic total lipids, with particular consideration of ratios of fatty acids indicative of Δ9-, Δ6- and Δ5-desaturation, was also less influenced by dietary CLA. In conclusion, the study shows that dietary rumen-protected CLA has less effect on hepatic lipid metabolism in young heifers and does not induce the development of a fatty liver such as in mice.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 85%

Effect of a rumen‐protected conjugated linoleic acid mixture on hepatic lipid metabolism in heifers

Shibani

Schlegel

Most

et al. 2011

Animal Physiology Nutrition

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“…Although the trans- 10, cis -12 CLA-induced responses in FA oxidation are variable in mice, consistently increased lipogenesis (Table 2) suggests a potential role for n-3 PUFA. On the contrary, CLA feeding increased n-3 PUFA content and decreased n-6 PUFA in the rats [119, 120] which could probably explain the differences in CLA effects between the two species. Although the exact mechanism of CLA action has not been elucidated, Banni et al [121] has suggested that the metabolites of CLA, conjugated dienes (CD)18:3, CD20:3, CD20:4, could compete with other PUFA at the level of formation and metabolism in liver and affect LC-PUFA synthesis.…”

Section: Physiological Effects Of Clamentioning

confidence: 99%

Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression

Vyas

Kadegowda

Erdman

2012

Journal of Nutrition and Metabolism

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Objective. To summarize the recent studies on effect of conjugated linoleic acid (CLA) on hepatic steatosis and hepatic and adipose lipid metabolism highlighting the potential regulatory mechanisms. Methods. Sixty-four published experiments were summarized in which trans-10, cis-12 CLA was fed either alone or in combination with other CLA isomers to mice, rats, hamsters, and humans were compared. Summary and Conclusions. Dietary trans-10, cis-12 CLA induces a severe hepatic steatosis in mice with a more muted response in other species. Regardless of species, when hepatic steatosis was present, a concurrent decrease in body adiposity was observed, suggesting that hepatic lipid accumulation is a result of uptake of mobilized fatty acids (FA) from adipose tissue and the liver's inability to sufficiently increase FA oxidation and export of synthesized triglycerides. The potential role of liver FA composition, insulin secretion and sensitivity, adipokine, and inflammatory responses are discussed as potential mechanisms behind CLA-induced hepatic steatosis.

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“…A possible drawback combining linolenic acid-fortified diets with CLA is that CLA is believed to compete with the D6-desaturase activity (Belury and Kempa-Steczko, 1997) and thus, impede accumulation of the longer chain (C20-22) fatty acids of the n-3 series. Recent results from a study with rats are promising as they revealed that compared with animals fed sunflower oil and linseed oil those fed CLA and linseed oil had the highest concentrations of long-chain (n-3) PUFA deriving from D6, D5 and D4-desaturation of linolenic acid in liver phospholipids (Eder et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effects of two supplementation levels of linseed combined with CLA or tallow on meat quality traits and fatty acid profile of adipose and different muscle tissues in slaughter pigs

Bee

Jacot

Guex

et al. 2008

Animal

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Dietary linseed supply efficiently elevates the linolenic acid concentration of pork. The main problem of increasing the n-3 fatty acid tissue levels arises from a higher susceptibility to lipid oxidation. Increasing the saturation level of tissue lipids by the dietary inclusion of conjugated linoleic acids (CLA) or tallow might prevent oxidation. Thus, the aim of the study was to evaluate the impact of dietary CLA or tallow supplementation combined with extruded linseed on the growth performance, carcass characteristics and fatty acid profile of muscles (longissimus, semimembranosus, biceps femoris) and subcutaneous fat (SF). The enzyme activity of the de novo lipogenesis and stearoyl-CoA desaturase in the SF was also assessed. From 18 to 104 kg BW, 32 Swiss Large White barrows were fed a diet supplemented with either: (1) 2% linseed (L2); (2) 3% linseed (L3); (3) 2% linseed 1 1% CLA (L2-C) or (4) 2% linseed 1 1% tallow (L2-T). The linolenic and eicosatrienoic acid concentrations were higher (P , 0.01) and the P n-6/ P n-3 ratio was lower (P , 0.01) in all tissues of L3 than L2 and L2-T barrows. Only in the SF the docosapentaenoic acid concentration was increased (P , 0.01) in L3 barrows. Compared with the other three diets, feeding the L2-C diets increased (P , 0.01) the amount of myristic, palmitic, stearic and palmitoleic acid at the expense of the oleic and eicosenoic acid content in the intramuscular and SF lipids. Except for the lower (P , 0.05) eicosadienoic acid concentration in the muscles, feeding the L2-C treatment resulted in similar polyunsaturated fatty acid concentrations and P n-6/ P n-3 ratio than feeding L2 or L2-T diets. Both the c9,t11-and t10,c12-CLA isomers found in the CLA-supplemented diet were also detected in the tissues, but the c9,t11-isomer was more abundant than the t10,c12-isomer. De novo lipogenesis was not (P . 0.05) affected by the dietary fats, whereas D9-desaturase activity was depressed (P , 0.05) by CLA inclusion (L2-C). Only when oxidation was challenged by cooking and subsequent storage for 4 days at 48C values of thiobarbituric acid-reactive substances were lower (P , 0.05) in longissimus muscle chops of L2-C compared with L2, L3 and L2-T barrows. The present findings revealed that CLA, but not tallow, combined with extruded linseed enhanced the oxidative stability of pork probably by lowering the degree of unsaturation of the lipids without affecting the improved P n-6/ P n-3 ratio.

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Effect of linseed oil supplementation on concentrations of (n‐3) polyunsaturated fatty acids in liver phospholipids of rats fed diets containing either an oil rich in conjugated linoleic acids, sunflower oil or high‐oleic acid sunflower oil

Cited by 9 publications

References 36 publications

Effect of a rumen‐protected conjugated linoleic acid mixture on hepatic lipid metabolism in heifers

Effect of a rumen‐protected conjugated linoleic acid mixture on hepatic lipid metabolism in heifers

Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression

Effects of two supplementation levels of linseed combined with CLA or tallow on meat quality traits and fatty acid profile of adipose and different muscle tissues in slaughter pigs

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