Effect of linoleic acid on proliferation and gene expression in the breast cancer cell line T47D

Reyes, Niradiz; Reyes, Ismael; Tiwari, Raj K.; Geliebter, Jan

doi:10.1016/j.canlet.2003.12.010

Cited by 44 publications

(36 citation statements)

References 38 publications

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“…CDLC contains N-6 fatty acids, such as LA and AA, which had been widely recognized to enhance the risk of breast cancer (16). In addition, LA and AA have also been reported to stimulate breast cancer cell proliferation (17,18). We thus focused on these two fatty acids in our present study.…”

Section: Discussionmentioning

confidence: 99%

17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis

Nagasaki

Suzuki²,

Miki³

et al. 2009

Cancer Research

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Abstract17B-Hydroxysteroid dehydrogenase type 12 (17B-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17B-HSD12 expression was also reported in breast carcinomas but its functions have remained unknown. In this study, we examined the correlation between mRNA expression profiles determined by microarray analysis and tissue E2 concentrations obtained from 16 postmenopausal breast carcinoma cases. No significant correlations were detected between 17B-HSD12 expression and E2 concentration. We then immunolocalized this enzyme in 110 cases of invasive ductal carcinoma. 17B-HSD12 immunoreactivity in breast carcinoma cells was significantly associated with poor prognosis of the patients. We further examined the biological significance of 17B-HSD12 using cell-based studies. Small interfering RNA-mediated knockdown of 17B-HSD12 in SK-BR-3 (estrogen receptornegative breast carcinoma cell line) resulted in significant growth inhibition, which was recovered by the addition of VLCFAs such as arachidonic acid. The status of 17B-HSD12 immunoreactivity was also correlated with adverse clinical outcome in cyclooxygenase 2 (COX2)-positive breast cancer patients but not in COX2-negative patients. Therefore, these findings indicated that 17B-HSD12 was not necessarily related to intratumoral E2 biosynthesis, at least in human breast carcinoma, but was rather correlated with production of VLCFAs such as arachidonic acid, which may subsequently be metabolized to prostaglandins by COX2 and result in tumor progression of the patients. [Cancer Res 2009;69(4):1392-9]

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Section: Discussionmentioning

confidence: 99%

17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis

Nagasaki

Suzuki²,

Miki³

et al. 2009

Cancer Research

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“…When the conductivity of this measuring solution is recorded continuously, an oxidation curve is obtained whose point of inflection is known as the induction time, which provides a good characteristic value for the oxidation stability ). The high amounts of linoleic acid in millet bran oil may have favorable nutritional implications and beneficial physiological effect in the prevention of coronary heart disease and cancer (Reyes et al 2004;Harris 2008), however, it also makes them especially prone to oxidation. As shown in Fig.…”

Section: Oil Oxidative Stabilitymentioning

confidence: 99%

Preparation and characterization of foxtail millet bran oil using subcritical propane and supercritical carbon dioxide extraction

Shi

Zhang

et al. 2014

J Food Sci Technol

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The foxtail millet (Setaria italica Beauv) bran oil was extracted with traditional solvent extraction (SE), supercritical carbon dioxide extraction (SCE) and subcritical propane extraction (SPE) and analyzed the yield, physicochemical property, fatty acid profile, tocopherol composition, oil oxidative stability in this study. The yields of foxtail millet bran oil by SE, SCE and SPE were 17.14 %, 19.65 %, 21.79 % of raw material weight (corresponded to 75.54 %, 86.60 %, 96.03 % of the total amount of the oil measured by using Soxhlet extraction), respectively. The effect of the extraction methods on the physicochemical properties (peroxide value, saponification value and color) was significant while the difference in fatty acid profile was negligible based on GC analysis. The major components of vitamin E in the obtained oils were identified as α-and β-tocopherols by HPLC, and SPE was superior to SE and SCE in the extraction of tocopherols. In Rancimat test, the oil obtained by SPE showed the highest oil oxidative stability, which could attribute to its high tocopherol content and low peroxide value. In view of oil quality, SPE employed smaller times and lower pressures compared to SE and SCE. SPE was a suitable and selective method for the extraction of the foxtail millet bran oil.

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“…For example, linoleate induced expression of the estrogen receptor which is known to be a growth stimulant when activated. On the other hand, linoleate decreased androgen receptor expression which is known to antagonize the effects of the estrogen receptor [71].…”

Section: Linoleatementioning

confidence: 99%

Optimizing Dietary Fat to Reduce Breast Cancer Risk: Are we there Yet?

Evans¹,

Hardy²

2014

TOBCANJ

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For over 70 years, long chain fatty acids have been implicated in the development and progression of breast cancer. Although the exact role remains to be elucidated, dietary factors have been implicated in approximately 35% of cancer deaths. Currently, biomarker, animal and in vitro studies suggest that the individual fatty acids have differing roles in the promotion or prevention of breast cancer development and progression. The goal of this review is to assess epidemiological, animal and cellular studies with respect to the role of dietary long chain fatty acids in breast cancer risk. Subsequently we identify the common findings in these studies, discuss important factors that may influence human studies and evaluate the current dietary fat recommendations with respect to these findings.

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Effect of linoleic acid on proliferation and gene expression in the breast cancer cell line T47D

Cited by 44 publications

References 38 publications

17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis

17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis

Preparation and characterization of foxtail millet bran oil using subcritical propane and supercritical carbon dioxide extraction

Optimizing Dietary Fat to Reduce Breast Cancer Risk: Are we there Yet?

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