Effect of ligands and other metals on the uptake of mercury and methylmercury across the gills and the intestine of the blue crab (Callinectes sapidus)

Laporte, Jean-Michel; Andrès, Sandrine

doi:10.1016/s1532-0456(01)00289-7

Cited by 31 publications

(49 citation statements)

References 27 publications

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“…The findings from these studies indicate that there are passive and active mechanisms involved in the uptake of Hg 2+ across the plasma membranes of enterocytes Laporte et al, 2002). It is likely that amino acids and peptides present in digested food bind to Hg 2+ and that the complexes formed are taken up by active and/or facilitated mechanisms involving amino acid and/or peptide transporters.…”

Section: Molecular Mimicry and The Intestinal Transport Of Hg 2+mentioning

confidence: 84%

Molecular and ionic mimicry and the transport of toxic metals

Bridges

Zalups

2005

Toxicology and Applied Pharmacology

667

460

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Despite many scientific advances, human exposure to, and intoxication by, toxic metal species continues to occur. Surprisingly, little is understood about the mechanisms by which certain metals and metal-containing species gain entry into target cells. Since there do not appear to be transporters designed specifically for the entry of most toxic metal species into mammalian cells, it has been postulated that some of these metals gain entry into target cells, through the mechanisms of ionic and/or molecular mimicry, at the site of transporters of essential elements and/or molecules. The primary purpose of this review is to discuss the transport of selective toxic metals in target organs and provide evidence supporting a role of ionic and/or molecular mimicry. In the context of this review, molecular mimicry refers to the ability of a metal ion to bond to an endogenous organic molecule to form an organic metal species that acts as a functional or structural mimic of essential molecules at the sites of transporters of those molecules. Ionic mimicry refers to the ability of a cationic form of a toxic metal to mimic an essential element or cationic species of an element at the site of a transporter of that element. Molecular and ionic mimics can also be sub-classified as structural or functional mimics. This review will present the established and putative roles of molecular and ionic mimicry in the transport of mercury, cadmium, lead, arsenic, selenium, and selected oxyanions in target organs and tissues.

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Section: Molecular Mimicry and The Intestinal Transport Of Hg 2+mentioning

confidence: 84%

Molecular and ionic mimicry and the transport of toxic metals

Bridges

Zalups

2005

Toxicology and Applied Pharmacology

667

460

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“…The uptake pathways of mercury in the blue crab were studied by Andres et al (2002) and Laporte et al (2002) who reported that inorganic and organic mercury uptake across the gill and intestinal tissues of the crab are rapid and of the same order of magnitude, and that this is due to the relatively unspecific nature of the uptake, with the potential for accumulation of mercury by a variety of pathways. These studies support the idea that mercury uptake potential is similar despite the gender of the organism, which contrasts with what was observed in the field in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, more information is needed, since physiologic responses to contamination are species specific and estuarine resources other than S. plana are exploited in temperate climates. Predator species, both vertebrate and invertebrate, will be subject to biomagnification processes (mainly of methylmercury) along the food web and are likely to have higher mercury body burdens Laporte et al, 2002) being a health concern and justifying further research in the area.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the previous research on this species consist of laboratory studies, focusing on mercury mediated osmoregulatory impairment (Péqueux et al, 1996), the combined effects of salinity and pH on the bioaccumulation of mercury (Laporte et al, 1997) or feeding experiments using mercury contaminated food (Evans et al, 2000). Studies on a different decapod crustacean, the blue crab, focused on the transport mechanisms and fluxes of mercury across the membranes (gills and intestine) and suggest that inorganic and organic mercury uptake into the gills and intestine of this invertebrate is by a variety of pathways, both active and passive Laporte et al, 2002). Less information is available on field accumulation studies , and no information is available on the overall lifespan bioaccumulation pattern of this species, which would be an invaluable tool for decision makers when assessing the risks associated with C. maenas harvest in contaminated areas.…”

Section: Introductionmentioning

confidence: 99%

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Pattern and pathways for mercury lifespan bioaccumulation in Carcinus maenas

Coelho

Reis

Ventura

et al. 2008

Marine Pollution Bulletin

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a b s t r a c tCarcinus maenas is an important and exploited natural resource in temperate estuaries, being consumed by local populations and also used as fish bait. Through bioaccumulation and bioamplification processes occurring in polluted estuarine ecosystems, this species may directly or indirectly represent a major pathway for Human contamination. No information is available on the overall lifespan bioaccumulation pattern of mercury for this species, which would be an invaluable tool for assessing the risks associated with C. maenas harvest in contaminated areas. Taking that in mind, the main objectives of this work were to clarify the lifespan bioaccumulation pattern of mercury for this species. A consistent lifespan accumulation pattern was found for this species, both for total and organic mercury, and coherent differences were found between genders, suggesting different physiological responses to contamination. From our results two scenarios emerge: (a) for low mercury contamination areas where the diet is the major pathway for metal uptake, with higher levels in muscle and hepatopancreas (twice as high as in gills) and higher organic mercury fractions (as high as 80-90% in muscle), crabs bioaccumulate with age and (b) on high contaminated areas, environmental exposure is predominant, with higher levels found in gills (reaching 0.8 mg kg À1 ), lower organic fractions and no mercury increment with age. Detoxification strategies, dietary differences and species mobility may account for these two accumulation patterns.

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“…MeHg bioavailability and bioaccumulation usually exceeds that of inorganic mercury (Laporte et al, 2002;Manson, 2002;Oliveira Ribeiro et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Localization of Inorganic and Organic Mercury in the Liver and Kidney of Cyprinus carpio by Autometallography

Prodocimo

Neto²,

Grötzner³

et al. 2024

Ecotoxicol. Environ. Contam.

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Mercury bioaccumulation in different tissues largely depends upon metal chemical form and has important implications on tissue-specific toxicity. Then, simple tools for mercury tissue localization are very useful for understanding the toxicity of mercurial compounds in fishes. In the present study, inorganic and organic mercury distribution was investigated in carp Cyprinus carpio, utilizing autometallography. Juvenile C. carpio were exposed through force-feeding with mercury contaminated pelleted food at doses of 0.5 µg g -1 of Hg +2 or MeHg twice at 15 days interval, and killed 15 days after the second exposure for sampling. Organic mercury was observed inside hepatocytes and in biliary ducts of liver, whereas inorganic form of mercury was observed only in biliary ducts. In the kidney, mercury was observed mainly in renal tubules, with the predominance of inorganic over organic mercury. The present study demonstrated that autometallography is a useful tool for the tissue localization of two mercurial compounds in the liver and kidney of C. carpio after trophic exposure.Keywords: Autometallography, mercury, liver, kidney, Cyprinus carpio. Localização do mercúrio inorgânico e orgânico em fígado e rim de Cyprinus carpio através da autometalografia ResumoA bioacumulação de mercúrio em diferentes tecidos depende da forma química do metal e tem implicações importantes na toxicidade de tecidos específicos. Deste modo, ferramentas simples para a localização de mercúrio em tecidos são úteis para a compreensão da toxicidade de compostos mercuriais em peixes. No presente estudo, a distribuição de mercúrio inorgânico e orgânico foi investigada em carpa Cyprinus carpio, utilizando autometalografia. Exemplares juvenis de C. carpio foram expostos através de alimentação forçada com pellets de ração contaminada com mercúrio em doses de 0.5 µg g -1 Hg +2 ou MeHg duas vezes em um intervalo de quinze dias, e sacrificados 15 dias após a segunda exposição para amostragem. O mercúrio orgânico foi observado no interior dos hepatócitos e nos ductos biliares. No rim, o mercúrio foi observado principalmente nos túbulos renais, com predominância do mercúrio inorgânico sobre o orgânico. O presente estudo demonstrou que a autometalografia é uma ferramenta útil para a localização tecidual de dois compostos mercuriais em fígado e rim de C. carpio após exposição trófica.Palavras-chave: Autometalografia, mercúrio, fígado, rim, Cyprinus carpio.

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Effect of ligands and other metals on the uptake of mercury and methylmercury across the gills and the intestine of the blue crab (Callinectes sapidus)

Cited by 31 publications

References 27 publications

Molecular and ionic mimicry and the transport of toxic metals

Molecular and ionic mimicry and the transport of toxic metals

Pattern and pathways for mercury lifespan bioaccumulation in Carcinus maenas

Localization of Inorganic and Organic Mercury in the Liver and Kidney of Cyprinus carpio by Autometallography

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