Effect of lifestyle modification on serum chemerin concentration and its association with insulin sensitivity in overweight and obese adults with type 2 diabetes

Kim, So Hun; Lee, Seung Hwan; Ahn, Kwangwon; Lee, Dong Hoon; Suh, Young Ju; Cho, Soon Gu; Choi, Young-Wook; Lee, Dae Hyung; Lee, Seung Youn; Hong, Sung-Ho; Kim, Yong Seong; Jeon, Justin Y.; Nam, Moonsuk

doi:10.1111/cen.12249

Cited by 72 publications

(60 citation statements)

References 35 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The levels of chemerin, an adipokine identified fairly recently, were correlated with body mass index (BMI) and components of the metabolic syndrome in normal and overweight subjects [5,[7][8][9][10][11][12][13][14][15][16][17][18][19]. It has also been shown that the levels of chemerin in patients with metabolic syndrome are significantly correlated with BG, high density lipoprotein-cholesterol (HDL-C), CHOL, TG, CRP, fasting insulin and the homeostatic model assessment (HOMA) index [18,[20][21][22], whereas a negative correlation exists with the glomerular filtration rate (GFR) [23]. Studies also indicate that serum chemerin levels are significantly elevated in patients on chronic hemodialysis and are correlated with renal function [7].…”

Section: Discussionmentioning

confidence: 97%

Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats

Yu¹,

Zhang²,

Xu³

et al. 2015

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: Chemerin was introduced as a novel adipokine that plays a crucial role in insulin signaling and diabetic nephropathy. Serum chemerin levels are significantly elevated in type 2 diabetes patients with macroalbuminuria. However, the underlying mechanisms remain unclear. We conducted a preliminary investigation of the effects of the renin-angiotensin system (RAS) on chemerin expression in streptozotocin-induced diabetic rats. Methods: Streptozotocin-induced diabetic rats were randomized into control, diabetic, and irbesartan-treated groups. Real-time polymerase chain reaction was used to detect mRNA expression of chemerin, angiotensin II type 1a receptor (AT1a), angiotensin II type 1b receptor (AT1b) and angiotensin II type 2 receptor (AT2). Immunohistochemical staining was used to detect chemerin in renal tissues. Results: Expression levels of chemerin in renal tissues were significantly elevated in the diabetic group compared to the control group. In the irbesartan-treated group, chemerin expression levels and RAS-related protein levels (i.e. AT1a and AT1b) were markedly decreased compared to the diabetic group. Irbesartan treatment reduced chemerin overexpression and RAS-related protein levels in diabetic rats (i.e. AT1a and AT1b). Conclusion: Irbesartan may inhibit intrarenal RAS in diabetic rats, which may affect the expression of chemerin in the kidneys; however, the precise underlying mechanism remains to be determined.

show abstract

Section: Discussionmentioning

confidence: 97%

Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats

Yu¹,

Zhang²,

Xu³

et al. 2015

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…A lifestyle modification of T2DM patients, through practice of regular physical exercise, even in a moderate rate, and healthy diet habits should be encouraged. Indeed, according to Kim et al, 15 12 weeks of intensive lifestyle modification, which included supervised exercise sessions, significantly decreased serum chemerin level, which was associated with an improvement in insulin sensitivity.…”

Section: Discussionmentioning

confidence: 98%

The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients with Type 2 Diabetes Mellitus

Neuparth¹,

Proença

Santos‐Silva³

et al. 2014

Journal of Investigative Medicine

View full text Add to dashboard Cite

show abstract

“…In overweight and obese type 2 diabetes patients chemerin levels are positively correlated with HOMA-IR and fasting insulin and negatively with insulin sensitivity index (ISI). Changes in the chemerin concentration during 12 weeks intensive lifestyle modification are independently and negatively correlated with changes in ISI and positively with changes in fasting plasma glucose and total cholesterol [37]. Weight-loss is mostly found to reduce chemerin and to improve insulin sensitivity [38].…”

Section: Serum Chemerin and Metabolic Syndromementioning

confidence: 99%

Chemerin in Liver Diseases

2014

Endocrinol Metab Synd

View full text Add to dashboard Cite

Chemerin is a chemoattractant protein and moreover has a role in adipogenesis, angiogenesis and glucose homeostasis. Chemerin is primarily synthesized and secreted by adipocytes and hepatocytes. Chemerin receptors chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and CC-motif chemokine receptorlike 2 (CCRL2) are all expressed in the liver suggesting that chemerin may be relevant in liver physiology and pathophysiology. Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and is the most common cause of chronic liver injury. NAFLD and chronic hepatitis C virus infection are risk factors for hepatocellular carcinoma. Hepatic and serum chemerin have been analyzed in human and rodent NAFLD, in patients with chronic hepatitis C and patients with hepatocellular carcinoma. Chemerin, GPR1 and CMKLR1 deficient mice have been used to elucidate the role of these proteins in body weight gain and glucose homeostasis. The regulation of chemerin and CMKLR1 by adipokines, hormones and cytokines relevant in liver diseases has been studied in hepatocytes. The data published so far are briefly summarized herein. Current experimental findings do not provide evidence for a crucial role of chemerin in chronic liver diseases and further research is needed to evaluate a possible protective function of this protein in hepatocellular carcinoma.

show abstract

Effect of lifestyle modification on serum chemerin concentration and its association with insulin sensitivity in overweight and obese adults with type 2 diabetes

Cited by 72 publications

References 35 publications

Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats

Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats

The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients with Type 2 Diabetes Mellitus

Chemerin in Liver Diseases

Contact Info

Product

Resources

About