Effect of lifestyle intervention in patients with type 2 diabetes: A meta-analysis

Chen, Liang; Pei, Jian-Hao; Kuang, Jian; Chen, Hongmei; Chen, Zhong; Li, Zhongwen; Yang, Hongjiang

doi:10.1016/j.metabol.2014.10.018

Cited by 274 publications

(232 citation statements)

References 28 publications

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“…To date, lifestyle intervention including pharmacological management (Table 5) and bariatric surgery in morbidly obese patients have demonstrated greatest efficacy in delaying/preventing diabetes onset in pre-diabetic individuals, achievement of glycemic control and improvement in oral indices. 65 In the absence of screening, maintenance of oral health, healthy lifestyles promotion, emphasis on increasing health literacy and emphasis on implementing integrated medical-dental care delivery provide current best practices for mitigating disease onset or progression. Emerging non-invasive technologies surrounding glycemic assessment may mitigate screening barriers in the dental setting and may be incorporated as components of effective ICMs.…”

Section: Discussionmentioning

confidence: 99%

Status Update on Translation of Integrated Primary Dental-Medical Care Delivery for Management of Diabetic Patients

2017

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Escalating prevalence of both diabetes and periodontal disease, two diseases associated with bi-directional exacerbation, has been reported. Periodontal disease represents a modifiable risk factor that may reduce diabetes onset or progression, and integrated models of cross-disciplinary care are needed to establish and manage glycemic control in affected patients. An ad-hoc environmental scan of current literature and media sought to characterize factors impacting status of integrated care models based on review of the existing evidence base in literature and media surrounding: (1) current cross-disciplinary practice patterns, (2) epidemiological updates, (3) status on risk assessment and screening for dysglycemia in the dental setting, (4) status on implementation of quality metrics for oral health, (5) care model pilots, and (6) public health perspectives. The survey revealed: escalating prevalence of diabetes and periodontitis globally; greater emphasis on oral health assessment for diabetic patients in recent medical clinical practice guidelines; high knowledgeability surrounding oralsystemic impacts on diabetes and growing receptivity to medical-dental integration among medical and dental providers; increasing numbers of programs/studies reporting on positive impact of emerging integrated dental-medical care models on diabetic patient healthcare access and health outcomes; a growing evidence base for clinically significant rates of undiagnosed dysglycemia among dental patients reported by point-of-care pilot studies; no current recommendation for population-based screening for dysglycemia in dental settings pending a stronger evidence base; improved definition of true periodontitis prevalence in (pre)/diabetics; emerging recognition of the need for oral health quality indicators and tracking; evidence of persistence in dental access disparity; updated status on barriers to integration. The potential benefit of creating clinically-applicable integrated care models to support holistic management of an escalating diabetic population by targeting modifiable risk factors including periodontitis is being recognized by the health industry. Cross-disciplinary efforts supported by high quality research are needed to mitigate previously-and newly-defined barriers of care integration and expedite development and implementation of integrated care models in various practice settings. Implementation of quality monitoring in the dental setting will support definition of the impact and efficacy of interventional clinical care models on patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Status Update on Translation of Integrated Primary Dental-Medical Care Delivery for Management of Diabetic Patients

2017

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“…Diet and regular exercise from moderate to intense can improve glucose levels in patients with T2DM and those at risk for developing obese and T2DM. Lifestyle intervention is a proven strategy for reducing diabetes incidence [14,15]. Nevertheless, the intervention is considered effective only in the short term but is difficult to adhere to in the long run, thus limiting its effectiveness.…”

Section: Non-pharmacologic Treatmentmentioning

confidence: 99%

Type 2 Diabetes Mellitus- Disease, Diagnosis and Treatment

Zhao¹,

Xu²,

Wu³

et al. 2015

J Diabetes Metab

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Type 2 diabetes mellitus (T2DM) is a fast-growing disease and a leading global public health concern. Multiple complications are associated with T2DM. Patient education with lifestyle modifications and pharmacotherapy are main methods for treatment of patients afflicted with T2DM. Lifestyle interventions are effective strategies but usually persist for a short term whereas T2DM patients with long-term treatment still present challenges in many cases. In this review, we have briefly summarized recent progress for T2DM diagnosis and treatment. We attempt to provide an outline for T2DM diagnosis and treatment. In addition, we introduce Chinese herbal medicine as an alternate treatment for physicians and T2DM patients.

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“…The development of T2DM is a complex, multistep, and multifactorial process, involving various environmental and genetic factors. Previous studies have reported that hyperglycemia, hypertension, dyslipidemia, and increased blood sugar levels contribute to the development of this disease (Ahmadi et al, 2014;Chen, Pei, et al, 2015). However, not all individuals exposed to similar risk factors develop T2DM, suggesting that genetic variations might influence susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus

S¹,

Fang²,

Wb³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of three common polymorphisms (rs10754558, rs7512998, and rs12137901) of the gene NLR family, pyrin domain containing 3 (NLRP3) in the development of type 2 diabetes mellitus (T2DM). Between May 2013 and May 2014, 385 patients with T2DM and 401 control subjects were enrolled in our study. Genotyping of the three NLRP3 polymorphisms of interest was performed by polymerase chain reaction-restriction fragment length polymorphism. Unconditional logistic regression analyses showed that individuals carrying GG and GC+GG rs10754558 genotypes were at significantly increased risk of T2DM, with adjusted odds ratios (and 95% confidence intervals) of 1.81 (1.16-2.83) and 1.40 (1.04-1.88), respectively. In conclusion, we propose that the NLRP3 rs10754558 polymorphism contributes to the development of T2DM, but that rs7512998 and rs12137901 variants are not associated with susceptibility to this disease.

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Effect of lifestyle intervention in patients with type 2 diabetes: A meta-analysis

Abstract: The meta-analysis found that lifestyle intervention showed significant benefit in risk factors that are known to be associated with development of cardiovascular disease in patients with type 2 diabetes.

Cited by 274 publications

References 28 publications

Status Update on Translation of Integrated Primary Dental-Medical Care Delivery for Management of Diabetic Patients

Status Update on Translation of Integrated Primary Dental-Medical Care Delivery for Management of Diabetic Patients

Type 2 Diabetes Mellitus- Disease, Diagnosis and Treatment

Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus

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