Effect of lifestyle improvement program on the biomarkers of adiposity, inflammation and gut hormones in overweight/obese Asian Indians with prediabetes

Gokulakrishnan, Kuppan; Ranjani, Harish; Weber, Mary Beth; Pandey, Gautam Kumar; Anjana, Ranjit Mohan; Balasubramanyam, Muthuswamy; Prabhakaran, Dorairaj; Tandon, Nikhil; Narayan, K.M. Venkat; Mohan, Viswanathan

doi:10.1007/s00592-017-1015-9

Cited by 18 publications

(41 citation statements)

References 46 publications

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“…In the present work, at 1 year of follow-up, the FI group had the following changes: − 11, + 2 and + 8 mg/dl in total cholesterol, HDL and triglycerides, respectively. The greater decrease at 1 year of follow-up in total cholesterol in our FI group is similar to that reported by Gokulakrishnan et al (2016), who also used metformin plus lifestyle [27].…”

Section: Biochemistry Characteristicssupporting

confidence: 91%

“…Few studies have used metformin together with lifestyle modifications; the weight loss observed at 1 year of follow-up in these investigations was lower (− 4.2 [27] and − 2.5% [28]) than in the present study. The combined use of metformin, general assessment at every follow-up visit, adjustment of the diet every 2 months in II group, as well as the monthly sessions and the family support in the FI group, could be important factors that allowed a greater weight loss in our study groups.…”

Section: Discussioncontrasting

confidence: 75%

“…In contrast to other investigations, in our research we observed a greater decrease in fasting glucose values (− 7.0 and − 5.7%, II and FI group, respectively) than in those investigations in which only modification in the lifestyle was made (− 3.7%) [6]. Beside this, when comparing our results with fasting glucose reduction from other studies ((from − 1.9 to − 4.5%) in which they also used lifestyle modification plus metformin, we observed that our groups had greater fasting glucose reductions [27,28].…”

Section: Biochemistry Characteristicssupporting

confidence: 57%

“…The decrease in fasting glucose in the present study may be due to the general feedback and follow-up monthly of the group II, to the family support in the FI group and to the fact that both groups received metformin from the beginning of the intervention, unlike other studies in which metformin was not prescribed to all patients, and in some of them it was started after 4 months from the beginning of the intervention [27,28].…”

Section: Biochemistry Characteristicsmentioning

confidence: 59%

“…Lifestyle interventions are effective to reduce T2D risk [25][26][27]. The challenge is how to convince the patient to improve and maintain the changes in their lifestyle.…”

Section: Discussionmentioning

confidence: 99%

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Effect of a family and interdisciplinary intervention to prevent T2D: randomized clinical trial

et al. 2020

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Background: Lifestyle changes can reduce the risk of T2D; however, no study has evaluated the effect of a lifestyle intervention involving patients´family. The aim of this study was to compare the impact of an interdisciplinary family (FI) Vs individual intervention (II) on glucose metabolism, insulin resistance (IR), pancreatic β-cell function and cardiovascular risk markers in patients with prediabetes, as well as to measure the impact on their families' metabolic risk. Methods: Randomized Clinical Trial (RCT) to compare the impact of FI and II on IR and pancreatic β-cell function in subjects with prediabetes. There were 122 subjects with prediabetes (and 101 family members) randomized to FI or II. Data were collected in 2015-2016 and analyzed in 2017-2018. FI group had the support of their family members, who also received personalized diet and exercise recommendations; patients and their family members attended monthly a lifestyle enhancement program. II group received personalized diet and exercise recommendations. The follow-up was for 12 months. Glucose, IR, pancreatic β-cell function and secondary outcomes (body composition and lipid profile) were assessed at baseline, 6 and 12 months. Results: FI group improved area under the glucose curve (AUC) (from 18,597 ± 2611 to 17,237 ± 2792, p = 0.004) and the Matsuda index (from 3.5 ± 2.3 to 4.7 ± 3.5, p = 0.05) at 12 months. II group improved Disposition Index (from 1.5 ± 0.4 to 1.9 ± 0.73, p < .0001) at 12 months. The improvements achieved in weight and lipids at 6 months, were lost in II group at 12 moths, whereas in FI persisted. Adherence up to 12 months was not different between the study groups (FI 56% Vs II 60%). Conclusions: FI intervention was more effective by improving glucose AUC, insulin sensitivity and lipid profile, besides that, metabolic risk in family members of the FI group was maintained, while the risk of II group was increased. Trial registration: This study was retrospectively registered at clinicaltrials.gov on December 15, 2015 (NTC026365646).

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Section: Biochemistry Characteristicssupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 75%

Section: Biochemistry Characteristicssupporting

confidence: 57%

Section: Biochemistry Characteristicsmentioning

confidence: 59%

“…Lifestyle interventions are effective to reduce T2D risk [25][26][27]. The challenge is how to convince the patient to improve and maintain the changes in their lifestyle.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of a family and interdisciplinary intervention to prevent T2D: randomized clinical trial

et al. 2020

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Screening for Prediabetes and Type 2 Diabetes

Jonas

Crotty

Yun³

et al. 2021

JAMA

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The chemokine system and its role in obesity

Xue

Fan

et al. 2018

Journal Cellular Physiology

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The chemokine system is a complex arrangement of molecules that attract leukocytes to the site of injury or inflammation. This chemotactic behavior gives the system the name "Chemokine." The intricate and redundant nature of the chemokine system has made it a subject of ongoing scientific investigation.Obesity is characterized as low-grade systemic or chronic inflammation that is responsible for the release of cytokines, adipokines, and chemokines. Excessive tissue fat expansion triggers the release of chemokines, which in turn attract various leukocytes and activate the resident immune surveillance system, eventually leading to worsening of obesity and other related comorbidities. To date, 50 chemokines and 20 chemokine receptors that belong to the G-proteincoupled receptor family have been discovered, and over the past two decades, the physiological and pathological roles of many of these chemokines and their receptors have been elucidated. The objective of this review is to present an update on the link between chemokines and obesity under the light of recent knowledge.

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Effect of lifestyle improvement program on the biomarkers of adiposity, inflammation and gut hormones in overweight/obese Asian Indians with prediabetes

Abstract: Participants who underwent an intensive lifestyle improvement program showed metabolic benefits as well as favorable beneficial changes in systemic levels of adipokines, cytokines and gut hormones, not only during the intervention period, but also during 12-month follow-up period.

Cited by 18 publications

References 46 publications

Effect of a family and interdisciplinary intervention to prevent T2D: randomized clinical trial

Effect of a family and interdisciplinary intervention to prevent T2D: randomized clinical trial

Screening for Prediabetes and Type 2 Diabetes

The chemokine system and its role in obesity

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